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Aframomum melegueta secondary metabolites exhibit polypharmacology against SARS-CoV-2 drug targets: in vitro validation of furin inhibition.
Omotuyi IO, Nash O, Ajiboye BO, Olumekun VO, Oyinloye BE, Osuntokun OT, Olonisakin A, Ajayi AO, Olusanya O, Akomolafe FS, Adelakun N. Omotuyi IO, et al. Phytother Res. 2021 Feb;35(2):908-919. doi: 10.1002/ptr.6843. Epub 2020 Sep 22. Phytother Res. 2021. PMID: 32964551
One of the many plants with previous antiviral potency is against RNA viruses is Aframomum melegueta. In this study, one hundred (100) A. melegueta secondary metabolites have been mined and computational evaluated for inhibition of host furin, and SARS-COV-2 …
One of the many plants with previous antiviral potency is against RNA viruses is Aframomum melegueta. In this study, one hundr …
Aframomum melegueta prevents the ejaculatory complications of propylthiouracil-induced hypothyroidism in sexually experienced male rats: Evidence from intravaginal and fictive ejaculations.
Kemka Nguimatio FX, Deeh Defo PB, Wankeu-Nya M, Ngadjui E, Kamanyi A, Kamtchouing P, Watcho P. Kemka Nguimatio FX, et al. J Integr Med. 2019 Sep;17(5):359-365. doi: 10.1016/j.joim.2019.05.001. Epub 2019 May 4. J Integr Med. 2019. PMID: 31097346
OBJECTIVE: Hypothyroidism has been claimed to generate sexual dysfunctions such as ejaculatory disorders. Aframomum melegueta is an aphrodisiac plant with pro-ejaculatory properties. ...CONCLUSION: This study highlighted the ejaculatory disturbance of hypothyroidism …
OBJECTIVE: Hypothyroidism has been claimed to generate sexual dysfunctions such as ejaculatory disorders. Aframomum melegueta
Aframomum melegueta Seed Extract with Standardized Content of 6-Paradol Reduces Visceral Fat and Enhances Energy Expenditure in Overweight Adults - A Randomized Double-Blind, Placebo-Controlled Clinical Study.
Sudeep HV, Aman K, Jestin TV, Shyamprasad K. Sudeep HV, et al. Drug Des Devel Ther. 2022 Oct 28;16:3777-3791. doi: 10.2147/DDDT.S367350. eCollection 2022. Drug Des Devel Ther. 2022. PMID: 36329722 Free PMC article. Clinical Trial.
PURPOSE: Aframomum melegueta (grains of paradise) seeds have been demonstrated to possess thermogenic potential. However, it is necessary to validate the functional attributes of A. melegueta seed extract in human subjects. METHODS: In a double-blind, placebo …
PURPOSE: Aframomum melegueta (grains of paradise) seeds have been demonstrated to possess thermogenic potential. However, it i …
Antiviral activity of aframomum melegueta against severe acute respiratory syndrome coronaviruses type 1 and 2.
Mahoney O, Melo C, Lockhart A, Cornejal N, Alsaidi S, Wu Q, Simon J, Juliani R, Zydowsky TM, Priano C, Koroch A, Fernández Romero JA. Mahoney O, et al. S Afr J Bot. 2022 May;146:735-739. doi: 10.1016/j.sajb.2021.12.010. Epub 2021 Dec 18. S Afr J Bot. 2022. PMID: 34955582 Free PMC article.
Plant-based compounds with antiviral properties against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been identified in Aframomum melegueta through computational models. The seed extract have been traditionally used to treat different illnesses. …
Plant-based compounds with antiviral properties against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been identified in …
Two undescribed paradol-related specialized metabolites from Aframomum melegueta.
Zhang Z, Zulfiqar F, Ali Z, Khan IA. Zhang Z, et al. Nat Prod Res. 2021 Nov;35(21):3707-3713. doi: 10.1080/14786419.2020.1731743. Epub 2020 Feb 24. Nat Prod Res. 2021. PMID: 32093489
Aframomum melegueta seeds are widely used as a spice in Africa. Two undescribed paradol-related compounds, (S)-9-hydroxy-[6]-paradol (1) and (9S)-3,9-dihydroxydihydro-[6]-paradol (2) together with eight reported constituents (3-10) were isolated and characterised fr
Aframomum melegueta seeds are widely used as a spice in Africa. Two undescribed paradol-related compounds, (S)-9-hydroxy-[6]-p
Research progress in phytochemistry and biology of Aframomum species.
Amadi SW, Zhang Y, Wu G. Amadi SW, et al. Pharm Biol. 2016 Nov;54(11):2761-2770. doi: 10.3109/13880209.2016.1173068. Epub 2016 May 9. Pharm Biol. 2016. PMID: 27159353 Review.
CONTEXT: The African genus Aframomum (Zingiberaceae) is a group of diverse tropical plants frequently collected yet largely neglected taxonomically. ...A total of 71 research articles that report on the biological activity of extracts and chemical constituents were …
CONTEXT: The African genus Aframomum (Zingiberaceae) is a group of diverse tropical plants frequently collected yet largely ne …
Anti-adhesive activity of Aframomum melegueta major phenolics on lower respiratory tract pathogens.
El Dine RS, Elfaky MA, Asfour H, El Halawany AM. El Dine RS, et al. Nat Prod Res. 2021 Feb;35(4):539-547. doi: 10.1080/14786419.2019.1585843. Epub 2019 May 9. Nat Prod Res. 2021. PMID: 31070056
Recent studies have raised interest in the potential health effect of Aframomum melegueta, which is related to the phenolic content of its seeds. The methanolic extract of A. melegueta seeds showed a significant anti-adhesive effect against Staphylococcus aur …
Recent studies have raised interest in the potential health effect of Aframomum melegueta, which is related to the phenolic co …
Thirty days oral Aframomum melegueta extract elicited analgesic effect but influenced cytochrome p4501BI, cardiac troponin T, testicular alfa-fetoprotein and other biomarkers in rats.
Biobaku KT, Azeez OM, Amid SA, Asogwa TN, Abdullahi AA, Raji OL, Abdulhamid JA. Biobaku KT, et al. J Ethnopharmacol. 2021 Mar 1;267:113493. doi: 10.1016/j.jep.2020.113493. Epub 2020 Oct 20. J Ethnopharmacol. 2021. PMID: 33096199
ETHNOPHARMACOLOGICAL RELEVANCE: Pain is the commonest symptom of a disease and the percentage of persons manifesting one form of pain is growing globally. Aframomum melegueta (AM) is commonly used by traditional doctors as medication for many ailments such as body p …
ETHNOPHARMACOLOGICAL RELEVANCE: Pain is the commonest symptom of a disease and the percentage of persons manifesting one form of pain is gro …
Nephroprotective activity of Aframomum melegueta seeds extract against diclofenac-induced acute kidney injury: A mechanistic study.
Abdou RM, El-Maadawy WH, Hassan M, El-Dine RS, Aboushousha T, El-Tanbouly ND, El-Sayed AM. Abdou RM, et al. J Ethnopharmacol. 2021 Jun 12;273:113939. doi: 10.1016/j.jep.2021.113939. Epub 2021 Feb 18. J Ethnopharmacol. 2021. PMID: 33610709
ETHNOPHARMACOLOGICAL RELEVANCE: In Africa, Aframomum species have been traditionally used to treat illnesses such as inflammation, hypertension, diarrhea, stomachache and fever. Moreover, Aframomum melegueta seed extracts (AMSE) are used in traditional medici …
ETHNOPHARMACOLOGICAL RELEVANCE: In Africa, Aframomum species have been traditionally used to treat illnesses such as inflammation, hy …
Preventive effects of Aframomum melegueta extracts on the reproductive complications of propylthiouracil-induced hypothyroidism in male rat.
François Xavier KN, Patrick Brice DD, Modeste WN, Esther N, Albert K, Pierre K, Pierre W. François Xavier KN, et al. Andrologia. 2019 Aug;51(7):e13306. doi: 10.1111/and.13306. Epub 2019 May 10. Andrologia. 2019. PMID: 31074045
This work was undertaken to evaluate the protective effects of Aframomum melegueta on testicular functions and fertility of hypothyroid male rats. ...These results provide evidence that A. melegueta has a protective effect on fertility in hypothyroid conditio …
This work was undertaken to evaluate the protective effects of Aframomum melegueta on testicular functions and fertility of hy …
79 results