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Page 1
Targeting Neuroinflammation in Osteoarthritis with Intra-Articular Adelmidrol.
Guida F, Rocco M, Luongo L, Persiani P, Vulpiani MC, Nusca SM, Maione S, Coluzzi F. Guida F, et al. Biomolecules. 2022 Oct 11;12(10):1453. doi: 10.3390/biom12101453. Biomolecules. 2022. PMID: 36291664 Free PMC article. Review.
Preclinical and clinical investigations showed that the intra-articular administration of Adelmidrol significantly reduced MC infiltration, pro-inflammatory cytokine release, and cartilage degeneration. The combination of 1% high molecular weight hyaluronic acid and 2% …
Preclinical and clinical investigations showed that the intra-articular administration of Adelmidrol significantly reduced MC infiltr …
The anti-fibrotic efficacy of adelmidrol depends on hepatic PPARgamma levels.
Xiang H, Xiao J, Sun Z, Liu Z, Zhang J, Xiang H, Ren H, Hu P, Peng M. Xiang H, et al. Biomed Pharmacother. 2023 Sep;165:115051. doi: 10.1016/j.biopha.2023.115051. Epub 2023 Jun 28. Biomed Pharmacother. 2023. PMID: 37385215 Free article.
Adelmidrol exhibited a limited anti-fibrotic effect in CDAA-HFD-induced fibrosis. ...GW9662 reversed the pro-steatotic effect of adelmidrol and improved fibrosis. The anti-fibrotic outcomes of adelmidrol were related to hepatic PPARgamma levels, which depends …
Adelmidrol exhibited a limited anti-fibrotic effect in CDAA-HFD-induced fibrosis. ...GW9662 reversed the pro-steatotic effect of a …
Adelmidrol protects against non-alcoholic steatohepatitis in mice.
Nageeb MM, Khatab MI, Abdel-Sameea AA, Teleb NA. Nageeb MM, et al. Naunyn Schmiedebergs Arch Pharmacol. 2020 May;393(5):777-784. doi: 10.1007/s00210-019-01785-1. Epub 2019 Dec 18. Naunyn Schmiedebergs Arch Pharmacol. 2020. PMID: 31853615
This work aimed to investigate the possible protective effect of adelmidrol (PPAR alpha and gamma agonist) against NASH in mice.Thirty-six mice were divided into six equal groups: sham-operated, NASH, vehicle, adelmidrol 5 mg/kg, adelmidrol 10 mg/kg, and a …
This work aimed to investigate the possible protective effect of adelmidrol (PPAR alpha and gamma agonist) against NASH in mice.Thirt …
Adelmidrol ameliorates liver ischemia-reperfusion injury through activating Nrf2 signaling pathway.
Wu M, Liu X, Yu Q, Shi J, Guo W, Zhang S. Wu M, et al. Eur J Pharmacol. 2024 Feb 5;964:176224. doi: 10.1016/j.ejphar.2023.176224. Epub 2023 Dec 17. Eur J Pharmacol. 2024. PMID: 38110141
Liver ischemia/reperfusion (I/R) injury commonly occurs after various liver surgeries. Adelmidrol, an N- palmitoylethanolamide analog, has anti-inflammatory, anti-oxidant, and anti-injury properties. ...ML385, an inhibitor of nuclear factor erythroid2-related factor 2 (Nrf …
Liver ischemia/reperfusion (I/R) injury commonly occurs after various liver surgeries. Adelmidrol, an N- palmitoylethanolamide analog …
Oral Adelmidrol Administration Up-Regulates Palmitoylethanolamide Production in Mice Colon and Duodenum through a PPAR-gamma Independent Action.
Del Re A, Palenca I, Seguella L, Pesce M, Corpetti C, Steardo L, Rurgo S, Sarnelli G, Esposito G. Del Re A, et al. Metabolites. 2022 May 19;12(5):457. doi: 10.3390/metabo12050457. Metabolites. 2022. PMID: 35629962 Free PMC article.
We also revealed that Adelmidrol up regulated the enzymatic machinery responsible for PEA metabolism and catabolism. ...The findings suggest that Adelmidrol can maximize a PEA therapeutic-based approach in several intestinal morbidities....
We also revealed that Adelmidrol up regulated the enzymatic machinery responsible for PEA metabolism and catabolism. ...The findings …
Adelmidrol: A New Promising Antioxidant and Anti-Inflammatory Therapeutic Tool in Pulmonary Fibrosis.
Fusco R, Cordaro M, Genovese T, Impellizzeri D, Siracusa R, Gugliandolo E, Peritore AF, D'Amico R, Crupi R, Cuzzocrea S, Di Paola R. Fusco R, et al. Antioxidants (Basel). 2020 Jul 9;9(7):601. doi: 10.3390/antiox9070601. Antioxidants (Basel). 2020. PMID: 32660140 Free PMC article.
They lead to a progressive decline of pulmonary functions. Adelmidrol is an analogue of palmitoylethanolamide (PEA), which is a well-known anti-inflammatory and anti-oxidant compound. In this study, we investigated the efficacy of adelmidrol (10 mg/Kg) for bleomycin …
They lead to a progressive decline of pulmonary functions. Adelmidrol is an analogue of palmitoylethanolamide (PEA), which is a well- …
Adelmidrol, a palmitoylethanolamide analogue, as a new pharmacological treatment for the management of acute and chronic inflammation.
Impellizzeri D, Di Paola R, Cordaro M, Gugliandolo E, Casili G, Morittu VM, Britti D, Esposito E, Cuzzocrea S. Impellizzeri D, et al. Biochem Pharmacol. 2016 Nov 1;119:27-41. doi: 10.1016/j.bcp.2016.09.001. Epub 2016 Sep 4. Biochem Pharmacol. 2016. PMID: 27599446
In order to elucidate whether the action of adelmidrol is related to activation of peroxisome proliferator-activated receptors (PPAR-alpha or PPAR-gamma), we investigated the effects of PPAR-gamma antagonist, GW9662 on adelmidrol mechanism. CAR induced paw edema, hy …
In order to elucidate whether the action of adelmidrol is related to activation of peroxisome proliferator-activated receptors (PPAR- …
Aerosol-Administered Adelmidrol Attenuates Lung Inflammation in a Murine Model of Acute Lung Injury.
Interdonato L, D'amico R, Cordaro M, Siracusa R, Fusco R, Peritore AF, Gugliandolo E, Crupi R, Coaccioli S, Genovese T, Impellizzeri D, Di Paola R, Cuzzocrea S. Interdonato L, et al. Biomolecules. 2022 Sep 16;12(9):1308. doi: 10.3390/biom12091308. Biomolecules. 2022. PMID: 36139146 Free PMC article.
The pathophysiology of ALI is characterized by increased alveolar/capillary permeability, lung inflammation, oxidative stress and structural damage to lung tissues, which can progress to acute respiratory distress syndrome (ARDS). Adelmidrol (ADM), an analogue of palmitoyl …
The pathophysiology of ALI is characterized by increased alveolar/capillary permeability, lung inflammation, oxidative stress and structural …
Adelmidrol, a Palmitoylethanolamide Analogue, as a New Pharmacological Treatment for the Management of Inflammatory Bowel Disease.
Cordaro M, Impellizzeri D, Gugliandolo E, Siracusa R, Crupi R, Esposito E, Cuzzocrea S. Cordaro M, et al. Mol Pharmacol. 2016 Nov;90(5):549-561. doi: 10.1124/mol.116.105668. Epub 2016 Sep 13. Mol Pharmacol. 2016. PMID: 27625036
Additionally, to clarify whether the protective action of adelmidrol is dependent on the activation of peroxisome proliferator-activated receptors (PPARs), we investigated the effects of a PPARgamma antagonist, GW9662, on adelmidrol action. ...It also decreased the …
Additionally, to clarify whether the protective action of adelmidrol is dependent on the activation of peroxisome proliferator-activa …
Adelmidrol increases the endogenous concentrations of palmitoylethanolamide in canine keratinocytes and down-regulates an inflammatory reaction in an in vitro model of contact allergic dermatitis.
Petrosino S, Puigdemont A, Della Valle MF, Fusco M, Verde R, Allarà M, Aveta T, Orlando P, Di Marzo V. Petrosino S, et al. Vet J. 2016 Jan;207:85-91. doi: 10.1016/j.tvjl.2015.10.060. Epub 2015 Nov 10. Vet J. 2016. PMID: 26639824
Brain or HEK-293 cell membrane fractions were used to assess the ability of adelmidrol to inhibit FAAH and NAAA activity, respectively. HaCaT cells were stimulated with polyinosinic-polycytidylic acid and the release of the pro-inflammatory chemokine, monocyte chemotactic …
Brain or HEK-293 cell membrane fractions were used to assess the ability of adelmidrol to inhibit FAAH and NAAA activity, respectivel …
31 results