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Page 1
Applying a Gene Reversal Rate Computational Methodology to Identify Drugs for a Rare Cancer: Inflammatory Breast Cancer.
Ji X, Williams KP, Zheng W. Ji X, et al. Cancer Inform. 2023 Oct 14;22:11769351231202588. doi: 10.1177/11769351231202588. eCollection 2023. Cancer Inform. 2023. PMID: 37846218 Free PMC article.
AZD-7545, BMS-754807, and nimesulide target known IBC relevant genes: PDK, Met, and COX, respectively. AG-14361, butalbital, and clobenpropit are known to be functionally relevant in DNA damage, cell cycle, and apoptosis, respectively. ...
AZD-7545, BMS-754807, and nimesulide target known IBC relevant genes: PDK, Met, and COX, respectively. AG-14361, butalbital, a …
The Effect of Endogenous PARP-1 in Different Phases of IL-1β-Induced Chondrocyte Degeneration.
Du X, Zhang S, Huang C, Wang G, Wang N, Hu Y. Du X, et al. Altern Ther Health Med. 2023 Jul;29(5):410-416. Altern Ther Health Med. 2023. PMID: 37052975 Free article.
METHODS: We used the primary CHs and treated them with interleukin-1 beta for up to 5 days. (IL-1beta) to induce degeneration. Meanwhile, we used AG-14361 (AG) to inhibit endogenous PARP-1 expression. Cell survival and collagen II expression were used to define the …
METHODS: We used the primary CHs and treated them with interleukin-1 beta for up to 5 days. (IL-1beta) to induce degeneration. Meanwhile, we …
Resveratrol Attenuates Aβ25-35 Caused Neurotoxicity by Inducing Autophagy Through the TyrRS-PARP1-SIRT1 Signaling Pathway.
Deng H, Mi MT. Deng H, et al. Neurochem Res. 2016 Sep;41(9):2367-79. doi: 10.1007/s11064-016-1950-9. Epub 2016 May 14. Neurochem Res. 2016. PMID: 27180189
Nevertheless, RSV-mediated autophagy was markedly abolished with the addition of inhibitors of SIRT1 (EX527), nicotinamide phosphoribosyltransferase (STF-118804), PARP1 (AG-14361), as well as SIRT1 and TyrRS small interfering RNA transfection, indicating that the ac …
Nevertheless, RSV-mediated autophagy was markedly abolished with the addition of inhibitors of SIRT1 (EX527), nicotinamide phosphoribosyltra …
21 results