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1989 2
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1996 10
1997 6
1999 8
2000 1
2001 2
2002 3
2003 1
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94 results

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Page 1
7-[(1R,2S,3S,5R)-6,6-dimethyl-3-(4- iodobenzenesulfonylamino)bicyclo[3.1.1]hept-2-yl]-5(Z)-heptenoic acid: a novel high-affinity radiolabeled antagonist for platelet thromboxane A2/prostaglandin H2 receptors.
Naka M, Mais DE, Morinelli TA, Hamanaka N, Oatis JE Jr, Halushka PV. Naka M, et al. J Pharmacol Exp Ther. 1992 Aug;262(2):632-7. J Pharmacol Exp Ther. 1992. PMID: 1386885
A high-affinity thromboxane (TX)A2/prostaglandin (PG) H2 receptor antagonist, I-SAP [7-[(1R,2S,3S,5R)-6,6-dimethyl-3-(4- iodobenzenesulfonylamino)bicyclo[3.1.1]hept-2-yl]-5(Z)-heptenoic acid] and its radiolabeled analog [125I]SAP (Mais et al., 1991) are characterized in th …
A high-affinity thromboxane (TX)A2/prostaglandin (PG) H2 receptor antagonist, I-SAP [7-[(1R,2S,3S,5R)-6,6-dimethyl-3-(4- iodobenzenesulfonyl …
Thromboxane A2 Activates YAP/TAZ Protein to Induce Vascular Smooth Muscle Cell Proliferation and Migration.
Feng X, Liu P, Zhou X, Li MT, Li FL, Wang Z, Meng Z, Sun YP, Yu Y, Xiong Y, Yuan HX, Guan KL. Feng X, et al. J Biol Chem. 2016 Sep 2;291(36):18947-58. doi: 10.1074/jbc.M116.739722. Epub 2016 Jul 5. J Biol Chem. 2016. PMID: 27382053 Free PMC article.
The TP-specific agonists [1S-[1alpha,2alpha(Z),3beta(1E,3S*),4 alpha]]-7-[3-[3-hydroxy-4-(4-iodophenoxy)-1-butenyl]-7-oxabicyclo[2.2.1]hept-2-yl]-5-heptenoic acid (I-BOP) and 9,11-dideoxy-9alpha,11alpha-methanoepoxy-prosta-5Z,13E-dien-1-oic acid (U-46619) induce YAP …
The TP-specific agonists [1S-[1alpha,2alpha(Z),3beta(1E,3S*),4 alpha]]-7-[3-[3-hydroxy-4-(4-iodophenoxy)-1-butenyl]-7-oxabicyclo[2.2.1]hept- …
Activation-dependent stabilization of the human thromboxane receptor: role of reactive oxygen species.
Wilson SJ, Cavanagh CC, Lesher AM, Frey AJ, Russell SE, Smyth EM. Wilson SJ, et al. J Lipid Res. 2009 Jun;50(6):1047-56. doi: 10.1194/jlr.M800447-JLR200. Epub 2009 Jan 16. J Lipid Res. 2009. PMID: 19151335 Free PMC article.
Thromboxane A(2) (TxA(2)), the principle product of platelet COX-1-dependent arachidonic acid metabolism, directs multiple pro-atherogenic processes via its receptor, TP. ...TP expression was augmented in TPalpha-transfected cells treated with a TxA(2) analog [1S-1alpha,2b …
Thromboxane A(2) (TxA(2)), the principle product of platelet COX-1-dependent arachidonic acid metabolism, directs multiple pro-athero …
Activation of NAD(P)H oxidases by thromboxane A2 receptor uncouples endothelial nitric oxide synthase.
Zhang M, Song P, Xu J, Zou MH. Zhang M, et al. Arterioscler Thromb Vasc Biol. 2011 Jan;31(1):125-32. doi: 10.1161/ATVBAHA.110.207712. Epub 2010 Oct 14. Arterioscler Thromb Vasc Biol. 2011. PMID: 20947827 Free PMC article.
METHODS AND RESULTS: Exposure of bovine aortic endothelial cells to either [1S-(1alpha,2beta(5Z),3alpha(1E,3R),4alpha]-7-[3-(3-hydroxy-4-(d'-iodophenoxy)-1-butenyl)-7-oxabicyclo-[2.2.1] heptan-2-yl]-5'-heptenoic acid (IBOP) or U46619, 2 structurally related TxA(2) mimetics …
METHODS AND RESULTS: Exposure of bovine aortic endothelial cells to either [1S-(1alpha,2beta(5Z),3alpha(1E,3R),4alpha]-7-[3-(3-hydroxy-4-(d' …
Characterization of an 125I-labeled thromboxane A2/prostaglandin H2 receptor agonist.
Morinelli TA, Oatis JE Jr, Okwu AK, Mais DE, Mayeux PR, Masuda A, Knapp DR, Halushka PV. Morinelli TA, et al. J Pharmacol Exp Ther. 1989 Nov;251(2):557-62. J Pharmacol Exp Ther. 1989. PMID: 2530338
In an attempt to overcome these problems, we have synthesized a stable, high affinity, 125I-radiolabeled TXA2/PGH2 receptor agonist, [1S-(1 alpha, 2 beta (5Z), 3 alpha(1E,3S*), 4 alpha)]-7-[3-(3-hydroxy-4-(4'-iodophenoxy)-1- …
In an attempt to overcome these problems, we have synthesized a stable, high affinity, 125I-radiolabeled TXA2/PGH2 receptor agonist, [1S-(1 …
A new family of thromboxane receptor antagonists with secondary thromboxane synthase inhibition.
Pace-Asciak CR, Reynaud D, Demin P, Aslam R, Sun A. Pace-Asciak CR, et al. J Pharmacol Exp Ther. 2002 May;301(2):618-24. doi: 10.1124/jpet.301.2.618. J Pharmacol Exp Ther. 2002. PMID: 11961065
We demonstrate that the analogs inhibit the aggregation of human platelets in vitro evoked by the thromboxane receptor agonists, I-BOP ([1S-[1alpha,2alpha(Z),3beta(1E,3S*),4alpha]]-7-[3-[3-hydroxy-4-(4-iodophenoxy)-1-butenyl]-7-oxabi-cyclo[2.2.1]hept-2-yl]5-heptenoic acid) …
We demonstrate that the analogs inhibit the aggregation of human platelets in vitro evoked by the thromboxane receptor agonists, I-BOP ([1S- …
Homologous desensitization of human platelet thromboxane A2/prostaglandin H2 receptors.
Okwu AK, Ullian ME, Halushka PV. Okwu AK, et al. J Pharmacol Exp Ther. 1992 Jul;262(1):238-45. J Pharmacol Exp Ther. 1992. PMID: 1378092
Desensitization of platelet thromboxane (TX)A2/prostaglandin (PG)H2 receptors was induced by incubating platelet-rich plasma with the stable PGH2 analog 11 alpha,9 alpha-(epoxymethano)prosta-5Z,13E-dienoic acid (U46619) (1 microM). Iloprost, a stable prostacyclin analog, w …
Desensitization of platelet thromboxane (TX)A2/prostaglandin (PG)H2 receptors was induced by incubating platelet-rich plasma with the stable …
Thromboxane A2 agonist modulation of excitatory synaptic transmission in the rat hippocampal slice.
Hsu KS, Kan WM. Hsu KS, et al. Br J Pharmacol. 1996 Aug;118(8):2220-7. doi: 10.1111/j.1476-5381.1996.tb15666.x. Br J Pharmacol. 1996. PMID: 8864565 Free PMC article.
The sensitivity of postsynaptic neurones to glutamate receptor agonists, alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) or N-methyl-D-aspartate (NMDA), was unchanged by I-BOP (0.5 microM) pretreatment. 4. ...
The sensitivity of postsynaptic neurones to glutamate receptor agonists, alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AM …
Testosterone increases thromboxane A2 receptor density and responsiveness in rat aortas and platelets.
Matsuda K, Ruff A, Morinelli TA, Mathur RS, Halushka PV. Matsuda K, et al. Am J Physiol. 1994 Sep;267(3 Pt 2):H887-93. doi: 10.1152/ajpheart.1994.267.3.H887. Am J Physiol. 1994. PMID: 8092292

The threshold concentration of the TxA2 mimetic, [1S-(1 alpha, 2 beta(5Z),3 alpha(1E,3R*)4 alpha)]-7-[3-(3-hydroxy-4- (4'-iodophenoxy)-1-butenyl)-7-oxabicyclo[2.21]heptan-2-yl]-5 -heptenoic acid (I-BOP), to induce platelet aggregation was significantly (P < 0.01) decrea

…
The threshold concentration of the TxA2 mimetic, [1S-(1 alpha, 2 beta(5Z),3 alpha(1E,3R*)4 alpha)]-7-[3-(3-hydroxy-4- (4'-iodophenoxy)-1-but …
94 results