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1,2-dihydro-1,2-dihydroxy-5-methylchrysene, a major activated metabolite of the environmental carcinogen 5-methylchrysene.
Hecht SS, LaVoie E, Mazzarese R, Amin S, Bedenko V, Hoffmann D. Hecht SS, et al. Cancer Res. 1978 Jul;38(7):2191-4. Cancer Res. 1978. PMID: 350385
The major mutagenic metabolite (peak E) was identified as 1,2-dihydro-1,2-dihydroxy-5-methylchrysene (7.0% from 5-methylchrysene); Peak D was 7,8-dihydro-7,8-dihydroxy-5-methylchrysene (2.6% from 5-methylchrysene). ...
The major mutagenic metabolite (peak E) was identified as 1,2-dihydro-1,2-dihydroxy-5-methylchrysene (7.0% from 5-methylchrysene); Peak D wa …
Tumorigenicity of 5-methylchrysene dihydrodiols and dihydrodiol epoxides in newborn mice and on mouse skin.
Hecht SS, Radok L, Amin S, Huie K, Melikian AA, Hoffmann D, Pataki J, Harvey RG. Hecht SS, et al. Cancer Res. 1985 Apr;45(4):1449-52. Cancer Res. 1985. PMID: 3838497
5-Methylchrysene, (+/-)-trans-1,2-dihydro-1,2-dihydroxy-5-methylchrysene, (+/-)-trans-7,8-dihydro-7,8-dihydroxy-5-methylchrysene, (+/-)-trans-1,2-dihydroxy-anti-3,4-epoxy-1,2,3,4-tetrahydro-5-methylchrysene (anti-DE-I), (+/- …
5-Methylchrysene, (+/-)-trans-1,2-dihydro-1,2-dihydroxy-5-methylchrysene, (+/-)-trans-7,8-dihydro-7,8- …
Tumor-initiating activity of dihydrodiols formed metabolically from 5-methylchrysene.
Hecht SS, Rivenson A, Hoffmann D. Hecht SS, et al. Cancer Res. 1980 May;40(5):1396-9. Cancer Res. 1980. PMID: 7370979
The compounds tested were 1,2-dihydro-1,2-dihydroxy-5-methylchrysene, 7,8-dihydro-7,8-dihydroxy-5-methylchrysene, 9,10-dihydro-9,10-dihydroxy-5-methylchrysene, and 5-methylchrysene. ...The results indicate that 1,2-dihydro-1 …
The compounds tested were 1,2-dihydro-1,2-dihydroxy-5-methylchrysene, 7,8-dihydro-7,8-dihydroxy- …
Influence of bay-region methyl group on formation of 5-methylchrysene dihydrodiol epoxide:DNA adducts in mouse skin.
Melikian AA, LaVoie EJ, Hecht SS, Hoffmann D. Melikian AA, et al. Cancer Res. 1982 Apr;42(4):1239-42. Cancer Res. 1982. PMID: 7060000
For identification of these products, markers were prepared from 5-methylchrysene bay-region dihydrodiol epoxides. [5-14C]1,2-dihydroxy-3,4-epoxy-1,2,3,4-tetrahydro-5-methylchrysene and [5-14C]7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydro-5-methylchrysene were synthesized by react …
For identification of these products, markers were prepared from 5-methylchrysene bay-region dihydrodiol epoxides. [5-14C]1,2-dihydroxy-3,4- …