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Purification and characterization of rat liver naloxone reductase that is identical to 3alpha-hydroxysteroid dehydrogenase.
Yamano S, Nakamoto N, Toki S. Yamano S, et al. Xenobiotica. 1999 Sep;29(9):917-30. doi: 10.1080/004982599238164. Xenobiotica. 1999. PMID: 10548452
1. Rat liver cytosol produced exclusively 6beta-naloxol from naloxone in the presence of either NADPH or NADH at pH 7.4. The amount of 6beta-naloxol formed with NADPH was about four times that with NADH. ...
1. Rat liver cytosol produced exclusively 6beta-naloxol from naloxone in the presence of either NADPH or NADH at pH 7.4. The a …
Preliminary characterization of enzymes for reduction of naloxone and naltrexone in rabbit and chicken liver.
Roerig S, Fujimoto JM, Wang RI, Pollock SH, Lange D. Roerig S, et al. Drug Metab Dispos. 1976 Jan-Feb;4(1):53-8. Drug Metab Dispos. 1976. PMID: 56258
These secies were chosen because the relative amounts of diastereoisomeric products formed by enzymatic reduction between these species are so different; naloxone and naltrexone are converted in the chicken to 6alpha-naloxol and 6alpha-naltrexol, respectively, and in the rabbit t …
These secies were chosen because the relative amounts of diastereoisomeric products formed by enzymatic reduction between these species are …
Development and validation of a sensitive LC/MS/MS method for the simultaneous determination of naloxone and its metabolites in mouse plasma.
Jiang H, Wang Y, Shet MS, Zhang Y, Zenke D, Fast DM. Jiang H, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Sep 1;879(25):2663-8. doi: 10.1016/j.jchromb.2011.06.039. Epub 2011 Jul 3. J Chromatogr B Analyt Technol Biomed Life Sci. 2011. PMID: 21798826
A rapid, specific, and reliable LC-MS/MS based bioanalytical method was developed and validated for the simultaneous determination of naloxone (NLX) and its two metabolites, 6beta-naloxol (NLL) and naloxone-3beta-D-glucuronide (NLG) in mouse plasma. ...
A rapid, specific, and reliable LC-MS/MS based bioanalytical method was developed and validated for the simultaneous determination of naloxo …
Purification and characterization of two major forms of naloxone reductase from rabbit liver cytosol, new members of aldo-keto reductase superfamily.
Yamano S, Ichinose F, Todaka T, Toki S. Yamano S, et al. Biol Pharm Bull. 1999 Oct;22(10):1038-46. doi: 10.1248/bpb.22.1038. Biol Pharm Bull. 1999. PMID: 10549852
Rabbit liver cytosol produced approximately equal amounts of 6alpha-naloxol and 6beta-naloxol from naloxone in the presence of NADPH at pH 7.4, and contained at least four forms of naloxone reductase. The two major forms, NR1 and NR2, which catalyze the stereospecif …
Rabbit liver cytosol produced approximately equal amounts of 6alpha-naloxol and 6beta-naloxol from naloxone in the presence of …