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Disposition and biotransformation of 14C-etodolac in man.
Ferdinandi ES, Sehgal SN, Demerson CA, Dubuc J, Zilber J, Dvornik D, Cayen MN. Ferdinandi ES, et al. Xenobiotica. 1986 Feb;16(2):153-66. doi: 10.3109/00498258609043518. Xenobiotica. 1986. PMID: 2938343
Most of the identified urinary components were conjugates of etodolac and three hydroxylated metabolites (6-hydroxyetodolac, 7-hydroxyetodolac and 8-(1-hydroxyethyl)etodolac). ...
Most of the identified urinary components were conjugates of etodolac and three hydroxylated metabolites (6-hydroxyetodolac, 7 …
Etodolac, a novel antiinflammatory agent. The syntheses and biological evaluation of its metabolites.
Humber LG, Ferdinandi E, Demerson CA, Ahmed S, Shah U, Mobilio D, Sabatucci J, De Lange B, Labbadia F, Hughes P. Humber LG, et al. J Med Chem. 1988 Sep;31(9):1712-9. doi: 10.1021/jm00117a009. J Med Chem. 1988. PMID: 2970548
The syntheses of five metabolites of the antiinflammatory drug etodolac (1,8-diethyl-1,3,4,9-tetrahydropyrano-[3,4-b]indole-1-acetic acid) are described, viz. 6-hydroxyetodolac, N-methyletodolac, 4-ureidoetodolac, 8-(1'-hydroxy)etodolac, and 4-oxoetodolac. ...
The syntheses of five metabolites of the antiinflammatory drug etodolac (1,8-diethyl-1,3,4,9-tetrahydropyrano-[3,4-b]indole-1-acetic acid) a …