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Page 1
Synthesis of [7-(14) C]bergapten.
Filer CN, Rodgers T. Filer CN, et al. J Labelled Comp Radiopharm. 2014 Feb;57(2):102-3. doi: 10.1002/jlcr.3172. Epub 2014 Jan 10. J Labelled Comp Radiopharm. 2014. PMID: 24408218
Since past attempts to radiolabel 1 with (14) C were limited to only its 5-methoxy group, a synthesis of the required ring [7-(14) C]1 is now described. The literature reported precursor 4-methoxy-6-hydroxybenzofuran-5-carboxaldehyde (3) was Wittig reacted with stab …
Since past attempts to radiolabel 1 with (14) C were limited to only its 5-methoxy group, a synthesis of the required ring [7-(14) C]1 is no …
[A new cytotoxic isoflavane from Dalbergiae Odoriferae Lignum].
Zhu MM, Wang H, Mi CN, Mei WL, Gai CJ, Dai HF, Yu M, Wu XQ, Wang H. Zhu MM, et al. Zhongguo Zhong Yao Za Zhi. 2020 May;45(9):2122-2129. doi: 10.19540/j.cnki.cjcmm.20200107.202. Zhongguo Zhong Yao Za Zhi. 2020. PMID: 32495561 Chinese.
Their structures were determined by spectroscopic techniques as S-3'-hydroxy-7,2',4'-trimethoxyisoxane(1), 2-(2',4'-dimethoxyphenyl)-6-hydroxybenzofuran(2), 2-(2'-hydroxy-4'-methoxyphenyl)-6-methoxybenzofuran(3), 7,2',4'-trimethoxydihydroisoflavone(4), sativanone(5) …
Their structures were determined by spectroscopic techniques as S-3'-hydroxy-7,2',4'-trimethoxyisoxane(1), 2-(2',4'-dimethoxyphenyl)-6 …
The melanin synthesis inhibition and radical scavenging activities of compounds isolated from the aerial part of Lespedeza cyrtobotrya.
Lee MY, Kim JH, Choi JN, Kim J, Hwang GS, Lee C. Lee MY, et al. J Microbiol Biotechnol. 2010 Jun;20(6):988-94. doi: 10.4014/jmb.0905.05054. J Microbiol Biotechnol. 2010. PMID: 20622497 Free article.
Four active compounds were isolated based on LH-20 chromatography and HPLC, and the structures were elucidated on the basis of their LC-MS and NMR spectral data, as 2-(2,4-Dihydroxyphenyl)-6-hydroxybenzofuran (1), eriodictyol-7-O-glucopyranoside (2), haginin A (3), …
Four active compounds were isolated based on LH-20 chromatography and HPLC, and the structures were elucidated on the basis of their LC-MS a …
Active site labeling of dopamine beta-hydroxylase by two mechanism-based inhibitors: 6-hydroxybenzofuran and phenylhydrazine.
Farrington GK, Kumar A, Villafranca JJ. Farrington GK, et al. J Biol Chem. 1990 Jan 15;265(2):1036-40. J Biol Chem. 1990. PMID: 2295598 Free article.
6-Hydroxybenzofuran and phenylhydrazine are mechanism-based inhibitors of dopamine beta-hydroxylase (D beta H; EC 1.14.17.1). ...Inactivation of D beta H with [3H]6-hydroxybenzofuran gave only one labeled peptide, whereas inactivation with [14C]phenylh …
6-Hydroxybenzofuran and phenylhydrazine are mechanism-based inhibitors of dopamine beta-hydroxylase (D beta H; EC 1.14.17.1). …
Effect of Double Bond Position on 2-Phenyl-benzofuran Antioxidants: A Comparative Study of Moracin C and Iso-Moracin C.
Li X, Xie H, Zhan R, Chen D. Li X, et al. Molecules. 2018 Mar 24;23(4):754. doi: 10.3390/molecules23040754. Molecules. 2018. PMID: 29587376 Free PMC article.
Two 2-phenyl-benzofurans, moracin C {2-[3',5'-dihydroxy-4'-(3-methlbut-2-enyl)phenyl]-6-hydroxybenzofuran} and its isomer iso-moracin C{2-[3',5'-dihydroxy-4'-(3-methlbut-1-enyl)phenyl]-6-hydroxybenzofuran}, were comparatively studied using redox-relate …
Two 2-phenyl-benzofurans, moracin C {2-[3',5'-dihydroxy-4'-(3-methlbut-2-enyl)phenyl]-6-hydroxybenzofuran} and its isomer iso- …
Pyrrolidinyl benzofurans and benzodioxanes: Selective α4β2 nicotinic acetylcholine receptor ligands with different activity profiles at the two receptor stoichiometries.
Appiani R, Pallavicini M, Hamouda AK, Bolchi C. Appiani R, et al. Bioorg Med Chem Lett. 2022 Jun 1;65:128701. doi: 10.1016/j.bmcl.2022.128701. Epub 2022 Mar 25. Bioorg Med Chem Lett. 2022. PMID: 35346843 Free article.
As previously reported for the benzodioxane based analogues, hydroxylation at proper position of benzene ring results in high alpha4beta2 nAChR affinity and alpha4beta2 vs. alpha3beta4 nAChR selectivity. 7-Hydroxy-N-methyl-2-pyrrolidinyl-1,4-benzodioxane (2) and its 7- and 5-amin …
As previously reported for the benzodioxane based analogues, hydroxylation at proper position of benzene ring results in high alpha4beta2 nA …
Inhibitory effect of 2-arylbenzofurans from Erythrina addisoniae on protein tyrosine phosphatase-1B.
Na M, Hoang DM, Njamen D, Mbafor JT, Fomum ZT, Thuong PT, Ahn JS, Oh WK. Na M, et al. Bioorg Med Chem Lett. 2007 Jul 15;17(14):3868-71. doi: 10.1016/j.bmcl.2007.05.005. Epub 2007 May 6. Bioorg Med Chem Lett. 2007. PMID: 17517504
The new compounds were identified as 2-[2',4'-dihydroxy-3'-(3-methylbut-2-enyl)phenyl]-6-hydroxybenzofuran (1), 2-[2'-methoxy-4'-hydroxy-5'-(3-methylbut-2-enyl)phenyl]-6-hydroxybenzofuran (2), and 2-(2'-methoxy-4'-hydroxyphenyl)-5-(3-methylbut-2-enyl)- …
The new compounds were identified as 2-[2',4'-dihydroxy-3'-(3-methylbut-2-enyl)phenyl]-6-hydroxybenzofuran (1), 2-[2'-methoxy- …
Potential Moracin M Prodrugs Strongly Attenuate Airway Inflammation In Vivo.
Lee J, Mandava S, Ahn SH, Bae MA, So KS, Kwon KS, Kim HP. Lee J, et al. Biomol Ther (Seoul). 2020 Jul 1;28(4):344-353. doi: 10.4062/biomolther.2019.212. Biomol Ther (Seoul). 2020. PMID: 32388942 Free PMC article.
This compound at 10 mg/kg also significantly reduced IL-1beta concentration in the bronchoalveolar lavage fluid of the inflamed-lungs. KW02 was rapidly metabolized to 5-(6-hydroxybenzofuran-2-yl)-1,3-phenylene bis(dimethylcarbamate) (KW06) and moracin M when it was …
This compound at 10 mg/kg also significantly reduced IL-1beta concentration in the bronchoalveolar lavage fluid of the inflamed-lungs. KW02 …
Khellinone derivatives as blockers of the voltage-gated potassium channel Kv1.3: synthesis and immunosuppressive activity.
Baell JB, Gable RW, Harvey AJ, Toovey N, Herzog T, Hänsel W, Wulff H. Baell JB, et al. J Med Chem. 2004 Apr 22;47(9):2326-36. doi: 10.1021/jm030523s. J Med Chem. 2004. PMID: 15084131
In this study, we report the discovery of two new classes of Kv1.3 blockers based on the naturally occurring compound khellinone, 5-acetyl-4,7-dimethoxy-6-hydroxybenzofuran: (1) khellinone dimers linked via the alkylation of the 6-hydroxy groups and (2) chalcone der …
In this study, we report the discovery of two new classes of Kv1.3 blockers based on the naturally occurring compound khellinone, 5-acetyl-4 …
Drug Design, Synthesis and In Vitro Evaluation of Substituted Benzofurans as Hsp90 Inhibitors.
Kadasi S, Costa TEMM, Arukala N, Toshakani M, Duggineti C, Thota S, Dutta Gupta S, Raj S, Penido C, Henriques MG, Raghavendra NM. Kadasi S, et al. Med Chem. 2018;14(1):44-52. doi: 10.2174/1573406413666170623085534. Med Chem. 2018. PMID: 28641528
OBJECTIVE: In this article, the structure based drug design of substituted 2-aryl/heteroarylidene-6- hydroxybenzofuran-3(2H)-one analogues to optimize and mimic the pharmacophoric interactions of the valid Hsp90 inhibitor radicicolis focused. ...
OBJECTIVE: In this article, the structure based drug design of substituted 2-aryl/heteroarylidene-6- hydroxybenzofuran-3(2H)-o …
16 results