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Year Number of Results
1977 1
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1985 7
1986 10
1987 7
1988 8
1989 8
1990 6
1991 10
1992 6
1993 2
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127 results

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Page 1
Antipyrine as a probe for human oxidative drug metabolism: identification of the cytochrome P450 enzymes catalyzing 4-hydroxyantipyrine, 3-hydroxymethylantipyrine, and norantipyrine formation.
Engel G, Hofmann U, Heidemann H, Cosme J, Eichelbaum M. Engel G, et al. Clin Pharmacol Ther. 1996 Jun;59(6):613-23. doi: 10.1016/S0009-9236(96)90001-6. Clin Pharmacol Ther. 1996. PMID: 8681486
LKM-2 antibodies (anti-CYP2C) caused a 75% to 100% inhibition of norantipyrine and a 58% to 80% inhibition of 3-hydroxymethylantipyrine formation. Sulfaphenazole inhibited the formation of 3-hydroxymethylantipyrine and norantipyrine by about 50%. ...Ke …
LKM-2 antibodies (anti-CYP2C) caused a 75% to 100% inhibition of norantipyrine and a 58% to 80% inhibition of 3-hydroxymethylantip
Impact of dioxins on antipyrine metabolism in firefighters.
Chernyak YI, Merinova AP, Shelepchikov AA, Kolesnikov SI, Grassman JA. Chernyak YI, et al. Toxicol Lett. 2016 May 27;250-251:35-41. doi: 10.1016/j.toxlet.2016.04.006. Epub 2016 Apr 8. Toxicol Lett. 2016. PMID: 27067104
Antipyrine (AP) metabolism was used to assess factors associated with the activity of hepatic oxidative enzymes in firefighters. Emphasis was placed on 3-hydroxymethylantipyrine (3HMAP), the metabolite with the greatest dependence on dioxin-inducible cytochrome P450 …
Antipyrine (AP) metabolism was used to assess factors associated with the activity of hepatic oxidative enzymes in firefighters. Emphasis wa …
Metabolism of antipyrine and m-xylene in rats after prolonged pretreatment with xylene alone or xylene with ethanol, phenobarbital or 3-methylcholanthrene.
Elovaara E, Engström K, Häyri L, Hase T, Aitio A. Elovaara E, et al. Xenobiotica. 1989 Sep;19(9):945-60. doi: 10.3109/00498258909043153. Xenobiotica. 1989. PMID: 2815836
XYL inhalation exposure at 300 ppm in air (7 h/day, 4 days/week, for 1 or 4 weeks) did not alter the total 24-h recovery of AP and its major metabolites in urine, but the excretion profile changed compared with controls: 3-hydroxymethylantipyrine (3-HMA) increased ( …
XYL inhalation exposure at 300 ppm in air (7 h/day, 4 days/week, for 1 or 4 weeks) did not alter the total 24-h recovery of AP and its major …
Simultaneous determination of antipyrine, 4-hydroxyantipyrine, 3-hydroxymethylantipyrine and norantipyrine in urine by gas chromatography chemical ionization mass spectrometry.
Tang BK, Uchino H, Inaba T, Kalow W. Tang BK, et al. Biomed Mass Spectrom. 1982 Oct;9(10):425-8. doi: 10.1002/bms.1200091004. Biomed Mass Spectrom. 1982. PMID: 7171741
A simple, accurate and precise procedure was developed to quantify, in a single run, antipyrine, 4-hydroxyantipyrine, 3-hydroxymethylantipyrine and norantipyrine in urine. The stable isotope-labelled internal standards for the assay were obtained from a subject who …
A simple, accurate and precise procedure was developed to quantify, in a single run, antipyrine, 4-hydroxyantipyrine, 3-hydroxymet
An improved synthesis of 3-hydroxymethylantipyrine using antipyrine as starting material.
Buijs W, van Meeteren-Wälchli B, Breimer DD, van der Gen A. Buijs W, et al. Arzneimittelforschung. 1986 Mar;36(3):419-21. Arzneimittelforschung. 1986. PMID: 3707658
A partly new synthesis of 3-hydroxymethylantipyrine, an important metabolite of antipyrine in man and therefore frequently used as a reference substance, is described. The use of tri-n-butyltin hydride to reduce the vinyl bromide system in 3-hydroxymethyl-4-bromoant …
A partly new synthesis of 3-hydroxymethylantipyrine, an important metabolite of antipyrine in man and therefore frequently use …
Studies on the different metabolic pathways of antipyrine in rats: influence of phenobarbital and 3-methylcholanthrene treatment.
Danhof M, Krom DP, Breimer DD. Danhof M, et al. Xenobiotica. 1979 Nov;9(11):695-702. doi: 10.3109/00498257909042337. Xenobiotica. 1979. PMID: 119355
In 24 h 2.7% of the administered dose was excreted as unchanged antipyrine, 13.3% as 4-hydroxyantipyrine, 7.4% as norantipyrine, 28.9% as 3-hydroxymethylantipyrine and 1.1% as 3-carboxyantipyrine. 2. Treatment with phenobarbital decreased the antipyrine half-life fr …
In 24 h 2.7% of the administered dose was excreted as unchanged antipyrine, 13.3% as 4-hydroxyantipyrine, 7.4% as norantipyrine, 28.9% as …
Impact of AhRR (565C > G) polymorphism on dioxin dependent CYP1A2 induction.
Chernyak YI, Grassman JA. Chernyak YI, et al. Toxicol Lett. 2020 Mar 1;320:58-63. doi: 10.1016/j.toxlet.2019.12.002. Epub 2019 Dec 2. Toxicol Lett. 2020. PMID: 31805342
Multivariate models indicated that CYP1A2 activity, detected as urinary 3-hydroxymethylantipyrine, was significantly correlated with cotinine concentration and for those currently working as firefighters, dioxin body burden (beta = 0.54, p = 0.041). ...
Multivariate models indicated that CYP1A2 activity, detected as urinary 3-hydroxymethylantipyrine, was significantly correlate …
Assay of antipyrine and its main metabolites 3-hydroxymethylantipyrine, norantipyrine and 4-hydroxyantipyrine in urine.
Brendel E, Meineke I, de Mey C. Brendel E, et al. J Pharm Biomed Anal. 1989;7(12):1783-90. doi: 10.1016/0731-7085(89)80194-3. J Pharm Biomed Anal. 1989. PMID: 2490567
Two assay methods for antipyrine (AP) and its main metabolites 3-hydroxymethylantipyrine (3-HMA), norantipyrine (NORA) and 4-hydroxyantipyrine (4-HA) in urine samples have been compared. ...
Two assay methods for antipyrine (AP) and its main metabolites 3-hydroxymethylantipyrine (3-HMA), norantipyrine (NORA) and 4-h …
Elimination studies of antipyrine and its metabolites in healthy Saudi Arabians.
Ali HA, el-Yazigi A, Sieck JO, Døssing M, Saour J, Raines DA, Ernst P. Ali HA, et al. Hum Exp Toxicol. 1994 Oct;13(10):658-62. doi: 10.1177/096032719401301002. Hum Exp Toxicol. 1994. PMID: 7826682 Clinical Trial.
We measured the antipyrine clearance in 18 healthy Saudi subjects and determined the urinary excretion of three of its metabolites: 4-hydroxyantipyrine (4-OH AP), norantipyrine (NOR AP) and 3 hydroxymethylantipyrine (3-OHM AP) in 21 subjects. 2. The mean +/- SD of t …
We measured the antipyrine clearance in 18 healthy Saudi subjects and determined the urinary excretion of three of its metabolites: 4-hydrox …
127 results