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104 results

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Page 1
Hybridization and Mismatch Discrimination Abilities of 2',4'-Bridged Nucleic Acids Bearing 2-Thiothymine or 2-Selenothymine Nucleobase.
Habuchi T, Yamaguchi T, Aoyama H, Horiba M, Ito KR, Obika S. Habuchi T, et al. J Org Chem. 2019 Feb 1;84(3):1430-1439. doi: 10.1021/acs.joc.8b02863. Epub 2019 Jan 24. J Org Chem. 2019. PMID: 30632750
Oligonucleotides modified with 2'- O,4'- C-spirocyclopropylene-bridged nucleic acid (scpBNA) exhibit excellent duplex-forming ability with their complementary single-stranded RNA (ssRNA). Here, we demonstrate that scpBNA bearing a 2-thiothymine (scpBNA-S(2)T) or 2-s …
Oligonucleotides modified with 2'- O,4'- C-spirocyclopropylene-bridged nucleic acid (scpBNA) exhibit excellent duplex-forming ability with t …
The Effect of Methylation on the Triplet-State Dynamics of 2-Thiouracil: Time-Resolved Photoelectron Spectroscopy of 2-Thiothymine.
Ullrich S, Qu Y, Mohamadzade A, Shrestha S. Ullrich S, et al. J Phys Chem A. 2022 Nov 10;126(44):8211-8217. doi: 10.1021/acs.jpca.2c06051. Epub 2022 Nov 1. J Phys Chem A. 2022. PMID: 36318646
The ultrafast internal conversion and intersystem crossing dynamics of 2-thiouracil (2TU) and 2-thiothymine (2TT) are studied using time-resolved photoelectron spectroscopy to investigate the effect of methylation on the deactivation mechanism. ...
The ultrafast internal conversion and intersystem crossing dynamics of 2-thiouracil (2TU) and 2-thiothymine (2TT) are studied …
Excited-state dynamics of 6-aza-2-thiothymine and 2-thiothymine: highly efficient intersystem crossing and singlet oxygen photosensitization.
Kuramochi H, Kobayashi T, Suzuki T, Ichimura T. Kuramochi H, et al. J Phys Chem B. 2010 Jul 8;114(26):8782-9. doi: 10.1021/jp102067t. J Phys Chem B. 2010. PMID: 20552955
Significant influences of sulfur and aza substitution on excited-state dynamics in thymine analogues, 6-aza-2-thiothymine (ATT) and 2-thiothymine (2TT), were intensively studied by means of nanosecond transient absorption and time-resolved luminescence …
Significant influences of sulfur and aza substitution on excited-state dynamics in thymine analogues, 6-aza-2-thiothymine (ATT …
6-Aza-2-Thiothymine-Capped Gold Nanoclusters as Robust Antimicrobial Nanoagents for Eradicating Multidrug-Resistant Escherichia coli Infection.
Jiang HQ, Lu LY, Weng ZM, Huang KY, Yang Y, Deng HH, Xu YY, Chen W, Zhuang QQ. Jiang HQ, et al. ACS Omega. 2023 Nov 28;8(49):47123-47133. doi: 10.1021/acsomega.3c07114. eCollection 2023 Dec 12. ACS Omega. 2023. PMID: 38107925 Free PMC article.
Herein, we present a novel designed antibacterial agent-6-Aza-2-thiothymine-capped gold nanoclusters (ATT-AuNCs), which show excellent antibacterial activity against multidrug-resistant E. coli bacteria. ...
Herein, we present a novel designed antibacterial agent-6-Aza-2-thiothymine-capped gold nanoclusters (ATT-AuNCs), which show e …
Thioamide-Bridged Nucleic Acid (thioAmNA) Containing Thymine or 2-Thiothymine: Duplex-Forming Ability, Base Discrimination, and Enzymatic Stability.
Habuchi T, Yamaguchi T, Obika S. Habuchi T, et al. Chembiochem. 2019 Apr 15;20(8):1060-1067. doi: 10.1002/cbic.201800702. Epub 2019 Mar 4. Chembiochem. 2019. PMID: 30552742
The synthesis of thioAmNAs bearing either thymine (thioAmNA-T) or 2-thiothymine (thioAmNA-S(2) T) bases was successful, and the obtained monomers were introduced into designed oligonucleotides without noticeable by-product generation. ...
The synthesis of thioAmNAs bearing either thymine (thioAmNA-T) or 2-thiothymine (thioAmNA-S(2) T) bases was successful, and th …
2'-Modified oligonucleotides for antisense therapeutics.
Prakash TP, Bhat B. Prakash TP, et al. Curr Top Med Chem. 2007;7(7):641-9. doi: 10.2174/156802607780487713. Curr Top Med Chem. 2007. PMID: 17430205 Review.
This is, in part, due to the enhanced biophysical properties of second generation antisense oligonucleotides. 2'-Modifications that influence the sugar to adopt a 3'-endo sugar pucker can improve properties such as affinity. 2'-Modifications that provide a gauche effect and/or a …
This is, in part, due to the enhanced biophysical properties of second generation antisense oligonucleotides. 2'-Modifications that influenc …
RecA-mediated strand invasion of DNA by oligonucleotides substituted with 2-aminoadenine and 2-thiothymine.
Lahoud G, Arar K, Hou YM, Gamper H. Lahoud G, et al. Nucleic Acids Res. 2008 Dec;36(21):6806-15. doi: 10.1093/nar/gkn755. Epub 2008 Oct 25. Nucleic Acids Res. 2008. PMID: 18953036 Free PMC article.
The core sequence, which is substituted with 2-aminoadenine and 2-thiothymine, is weakly hybridized to complementary locked nucleic acid or 2'-OMe RNA ONs that are also substituted with the same base analogs. ...
The core sequence, which is substituted with 2-aminoadenine and 2-thiothymine, is weakly hybridized to complementary locked nu …
Communication: the dark singlet state as a doorway state in the ultrafast and efficient intersystem crossing dynamics in 2-thiothymine and 2-thiouracil.
Pollum M, Crespo-Hernández CE. Pollum M, et al. J Chem Phys. 2014 Feb 21;140(7):071101. doi: 10.1063/1.4866447. J Chem Phys. 2014. PMID: 24559331
Femtosecond broadband transient absorption experiments are reported for 2-thiothymine and 2-thiouracil in aqueous buffer solution and in acetonitrile. ...A sequential kinetic model is presented to explain the excited-state dynamics in 2-thiothymine and …
Femtosecond broadband transient absorption experiments are reported for 2-thiothymine and 2-thiouracil in aqueous buffer solut …
Micelle-mediated chemiluminescence of 6-aza-2-thiothymine-protected gold nanoclusters for carbazochrome sodium sulfonate detection.
Lin Z, Cai C, Chen W, Deng Q, Yang J, Huang K, Deng H, Lin X, Chen W, Yao W. Lin Z, et al. Spectrochim Acta A Mol Biomol Spectrosc. 2024 Mar 5;308:123738. doi: 10.1016/j.saa.2023.123738. Epub 2023 Dec 7. Spectrochim Acta A Mol Biomol Spectrosc. 2024. PMID: 38086230
Chemiluminescence (CL) intensity of luminol-H(2)O(2) system was dramatically enhanced by cetyltrimethylammonium bromide (CTAB) micelle-mediated 6-aza-2-thiothymine-protected gold nanoclusters (ATT-AuNCs). It is proved that spherical micelles of CTAB in aqueous solut …
Chemiluminescence (CL) intensity of luminol-H(2)O(2) system was dramatically enhanced by cetyltrimethylammonium bromide (CTAB) micelle-media …
Novel photoluminescence enzyme immunoassay based on supramolecular host-guest recognition using L-arginine/6-aza-2-thiothymine-stabilized gold nanocluster.
Wang Y, Lu M, Tang D. Wang Y, et al. Biosens Bioelectron. 2018 Jun 30;109:70-74. doi: 10.1016/j.bios.2018.03.007. Epub 2018 Mar 5. Biosens Bioelectron. 2018. PMID: 29529510
A new photoluminescence (PL) enzyme immunoassay was designed for sensitive detection of aflatoxin B(1) (AFB(1)) via an innovative enzyme substrate, 6-aza-2-thiothymine-stabilized gold nanocluster (AAT-AuNC) with L-arginine. ...
A new photoluminescence (PL) enzyme immunoassay was designed for sensitive detection of aflatoxin B(1) (AFB(1)) via an innovative enzyme sub …
104 results