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Antinociceptive Activity of Phloroglucinol Derivatives Isolated from Southern Brazilian Hypericum Species.
Bridi H, Dischkaln Stolz E, Maikon Corrêa de Barros F, Elingson da Silva Costa B, Guerini L, Maris Kuze Rates S, Lino von Poser G. Bridi H, et al. Chem Biodivers. 2018 Nov;15(11):e1800266. doi: 10.1002/cbdv.201800266. Epub 2018 Oct 26. Chem Biodivers. 2018. PMID: 30156379
In this study, a mixture of japonicine A and an isomer with an unreported structure, named japonicine E, was isolated from the roots of H. polyanthemum. Additionally, uliginosin A from H. myrianthum, isouliginosin B from H. polyanthemum, hyperbrasilol B and isohyper …
In this study, a mixture of japonicine A and an isomer with an unreported structure, named japonicine E, was isolated from the roots of H. p …
Acylphloroglucinol derivatives from Hypericum andinum: antidepressant-like activity of andinin A.
Ccana-Ccapatinta GV, Stolz ED, da Costa PF, Rates SM, von Poser GL. Ccana-Ccapatinta GV, et al. J Nat Prod. 2014 Oct 24;77(10):2321-5. doi: 10.1021/np500426m. Epub 2014 Sep 29. J Nat Prod. 2014. PMID: 25264905
A new dimeric acylphloroglucinol derivative, andinin A (1), was isolated from the underground plant parts of Hypericum andinum, along with three known dimeric acylphloroglucinols, uliginosin A (2), uliginosin B (3), and isouliginosin B (4). The structure of 1 was el …
A new dimeric acylphloroglucinol derivative, andinin A (1), was isolated from the underground plant parts of Hypericum andinum, along with t …
In vitro growth inhibition by Hypericum extracts and isolated pure compounds of Paenibacillus larvae, a lethal disease affecting honeybees worldwide.
Hernández-López J, Crockett S, Kunert O, Hammer E, Schuehly W, Bauer R, Crailsheim K, Riessberger-Gallé U. Hernández-López J, et al. Chem Biodivers. 2014 May;11(5):695-708. doi: 10.1002/cbdv.201300399. Chem Biodivers. 2014. PMID: 24827680
Six pure compounds isolated from these extracts, viz., hyperforin (1), uliginosin B (2), uliginosin A (3), 7-epiclusianone (4), albaspidin AA (5), and drummondin E (6), displayed strong antibacterial activity against the vegetative form of P. larvae (MIC ranging fro …
Six pure compounds isolated from these extracts, viz., hyperforin (1), uliginosin B (2), uliginosin A (3), 7-epiclusianone (4) …
Characterization of Phloroglucinol-enriched Fractions of Brazilian Hypericum Species and Evaluation of Their Effect on Human Keratinocytes Proliferation.
Bridi H, Beckenkamp A, Ccana-Ccapatinta GV, de Loreto Bordignon SA, Buffon A, von Poser GL. Bridi H, et al. Phytother Res. 2017 Jan;31(1):62-68. doi: 10.1002/ptr.5727. Epub 2016 Sep 13. Phytother Res. 2017. PMID: 27619474
The phloroglucinol-enriched fractions (PEF) of the flowering aerial parts were analyzed by high-performance liquid chromatography for the content of uliginosin A (1), japonicin A (2), uliginosin B (3), hyperbrasilol B (4), and the three benzopyrans, that is, 6-isobu …
The phloroglucinol-enriched fractions (PEF) of the flowering aerial parts were analyzed by high-performance liquid chromatography for the co …
Identification of anti-inflammatory constituents in Hypericum perforatum and Hypericum gentianoides extracts using RAW 264.7 mouse macrophages.
Huang N, Rizshsky L, Hauck C, Nikolau BJ, Murphy PA, Birt DF. Huang N, et al. Phytochemistry. 2011 Nov;72(16):2015-23. doi: 10.1016/j.phytochem.2011.07.016. Epub 2011 Aug 17. Phytochemistry. 2011. PMID: 21855951 Free PMC article.
These fractions were rich in acylphloroglucinols, including uliginosin A that accounted for a proportion of the anti-inflammatory activity observed with the active fractions. ...
These fractions were rich in acylphloroglucinols, including uliginosin A that accounted for a proportion of the anti-inflammat …
Antibacterial phloroglucinols and flavonoids from Hypericum brasiliense.
Rocha L, Marston A, Potterat O, Kaplan MA, Stoeckli-Evans H, Hostettmann K. Rocha L, et al. Phytochemistry. 1995 Nov;40(5):1447-52. doi: 10.1016/0031-9422(95)00507-4. Phytochemistry. 1995. PMID: 8534402
Three known phloroglucinols (japonicine A, uliginosin A and isouliginosin B) and a new phloroglucinol (hyperbrasiol A) have been isolated from a petrol extract of the leaves and flowers of Hypericum brasiliense. ...
Three known phloroglucinols (japonicine A, uliginosin A and isouliginosin B) and a new phloroglucinol (hyperbrasiol A) have be …
Synthesis of uliginosins A and B.
Kraus GA, Liu F. Kraus GA, et al. Nat Prod Commun. 2012 Feb;7(2):191-2. Nat Prod Commun. 2012. PMID: 22474952