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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1991 2
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1994 19
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1998 12
1999 17
2000 16
2001 17
2002 14
2003 15
2004 18
2005 14
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2007 22
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2009 25
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Page 1
Trypanosoma cruzi trans-Sialidase as a Potential Vaccine Target Against Chagas Disease.
da Costa KM, Marques da Fonseca L, Dos Reis JS, Santos MARDC, Previato JO, Mendonça-Previato L, Freire-de-Lima L. da Costa KM, et al. Front Cell Infect Microbiol. 2021 Oct 26;11:768450. doi: 10.3389/fcimb.2021.768450. eCollection 2021. Front Cell Infect Microbiol. 2021. PMID: 34765570 Free PMC article. Review.
One of the most important discoveries made since then, impacting the understanding of how the parasite interacts with the host's immune system, was the description of trans-sialidase. It is an unique enzyme, capable of masking the parasite's presence from the host, …
One of the most important discoveries made since then, impacting the understanding of how the parasite interacts with the host's immune syst …
Trans-sialidase Associated with Atherosclerosis: Defining the Identity of a Key Enzyme Involved in the Pathology.
Glanz VY, Myasoedova VA, Grechko AV, Orekhov AN. Glanz VY, et al. Curr Drug Targets. 2019;20(9):938-941. doi: 10.2174/1389450120666190308111619. Curr Drug Targets. 2019. PMID: 30848200 Review.
Atherosclerosis is associated with the increased trans-sialidase activity, which can be detected in the blood plasma of atherosclerosis patients. ...In this mini-review, we discuss the possibility that atherosclerosis- associated trans-sialidase does, …
Atherosclerosis is associated with the increased trans-sialidase activity, which can be detected in the blood plasma of athero …
Recent developments in trans-sialidase inhibitors of Trypanosoma cruzi.
Kashif M, Moreno-Herrera A, Lara-Ramirez EE, Ramírez-Moreno E, Bocanegra-García V, Ashfaq M, Rivera G. Kashif M, et al. J Drug Target. 2017 Jul;25(6):485-498. doi: 10.1080/1061186X.2017.1289539. Epub 2017 Feb 20. J Drug Target. 2017. PMID: 28140698 Review.
Chagas is a lethal chronic disease that currently affects 8-10 million people worldwide, primarily in South and Central America. Trypanosoma cruzi trans-sialidase is an enzyme that is of vital importance for the survival of the parasite due to its key role in the tr …
Chagas is a lethal chronic disease that currently affects 8-10 million people worldwide, primarily in South and Central America. Trypanosoma …
Trans-sialidase and mucins of Trypanosoma cruzi: an important interplay for the parasite.
Giorgi ME, de Lederkremer RM. Giorgi ME, et al. Carbohydr Res. 2011 Sep 6;346(12):1389-93. doi: 10.1016/j.carres.2011.04.006. Epub 2011 Apr 8. Carbohydr Res. 2011. PMID: 21645882 Review.
Sialic acid in the surface of the parasite plays an important role in the infectious process, however, T. cruzi is unable to synthesize sialic acid or the usual donor CMP-sialic acid. Instead, T. cruzi expresses a unique enzyme, the trans-sialidase (TcTS) involved i …
Sialic acid in the surface of the parasite plays an important role in the infectious process, however, T. cruzi is unable to synthesize sial …
The trans-sialidase, the major Trypanosoma cruzi virulence factor: Three decades of studies.
Freire-de-Lima L, Fonseca LM, Oeltmann T, Mendonça-Previato L, Previato JO. Freire-de-Lima L, et al. Glycobiology. 2015 Nov;25(11):1142-9. doi: 10.1093/glycob/cwv057. Epub 2015 Jul 29. Glycobiology. 2015. PMID: 26224786 Review.
Exactly 30 years ago, we presented evidence for the first time of a trans-sialidase activity in T. cruzi (T. cruzi-TS). This enzyme transfers sialic acid from the host glycoconjugates to the terminal beta-galactopyranosyl residues of mucin-like molecules on the para …
Exactly 30 years ago, we presented evidence for the first time of a trans-sialidase activity in T. cruzi (T. cruzi-TS). This e …
Trypanosoma cruzi Trans-sialidase: structural features and biological implications.
Oliveira IA, Freire-de-Lima L, Penha LL, Dias WB, Todeschini AR. Oliveira IA, et al. Subcell Biochem. 2014;74:181-201. doi: 10.1007/978-94-007-7305-9_8. Subcell Biochem. 2014. PMID: 24264246 Review.
Trypanosoma cruzi trans-sialidase (TcTS) has intrigued researchers all over the world since it was shown that T. cruzi incorporates sialic acid through a mechanism independent of sialyltransferases. ...
Trypanosoma cruzi trans-sialidase (TcTS) has intrigued researchers all over the world since it was shown that T. cruzi incorpo …
Trans-sialidase, SAPA amino acid repeats and the relationship between Trypanosoma cruzi and the mammalian host.
Frasch AC. Frasch AC. Parasitology. 1994;108 Suppl:S37-44. doi: 10.1017/s0031182000075703. Parasitology. 1994. PMID: 8084653 Review.
The amino acid repeats present in SAPA/transsialidase/neuraminidase are unrelated to the enzymic activity and constitute an immunodominant C-terminal domain. The N-terminal domain of SAPA/trans-sialidase/neuraminidase controls the enzymic activity since a recombinan …
The amino acid repeats present in SAPA/transsialidase/neuraminidase are unrelated to the enzymic activity and constitute an immunodominant C …
Parasite-host glycan interactions during Trypanosoma cruzi infection: trans-Sialidase rides the show.
Campetella O, Buscaglia CA, Mucci J, Leguizamón MS. Campetella O, et al. Biochim Biophys Acta Mol Basis Dis. 2020 May 1;1866(5):165692. doi: 10.1016/j.bbadis.2020.165692. Epub 2020 Jan 20. Biochim Biophys Acta Mol Basis Dis. 2020. PMID: 31972227 Free PMC article. Review.
Though unable to synthesize SA de novo, T. cruzi displays a unique trans-Sialidase (TS) enzyme, which is able to cleave terminal SA residues from host donor glycoconjugates and transfer them onto parasite surface mucins, thus generating protective/adhesive structure …
Though unable to synthesize SA de novo, T. cruzi displays a unique trans-Sialidase (TS) enzyme, which is able to cleave termin …
Trans-sialidase: a unique enzyme activity discovered in the protozoan Trypanosoma cruzi.
Colli W. Colli W. FASEB J. 1993 Oct;7(13):1257-64. doi: 10.1096/fasebj.7.13.8405811. FASEB J. 1993. PMID: 8405811 Review.
In the absence of an acceptor, the enzyme acts as a hydrolase transferring sialic acid to water. Trans-sialidase belongs to a highly heterogeneous gene family of surface molecules sharing with each other and with bacterial neuraminidases variable degrees of nucleoti …
In the absence of an acceptor, the enzyme acts as a hydrolase transferring sialic acid to water. Trans-sialidase belongs to a …
530 results