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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1953 1
1964 1
1974 1
1975 30
1976 49
1977 55
1978 110
1979 66
1980 72
1981 69
1982 95
1983 91
1984 89
1985 106
1986 102
1987 95
1988 87
1989 99
1990 94
1991 93
1992 94
1993 123
1994 117
1995 149
1996 122
1997 123
1998 122
1999 105
2000 105
2001 120
2002 82
2003 95
2004 105
2005 81
2006 82
2007 81
2008 84
2009 90
2010 58
2011 63
2012 83
2013 78
2014 62
2015 68
2016 43
2017 38
2018 60
2019 51
2020 62
2021 47
2022 44
2023 24
2024 4

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3,879 results

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Page 1
Structural insights into the inhibition mechanism of human sterol O-acyltransferase 1 by a competitive inhibitor.
Guan C, Niu Y, Chen SC, Kang Y, Wu JX, Nishi K, Chang CCY, Chang TY, Luo T, Chen L. Guan C, et al. Nat Commun. 2020 May 18;11(1):2478. doi: 10.1038/s41467-020-16288-4. Nat Commun. 2020. PMID: 32424158 Free PMC article.
Sterol O-acyltransferase 1 (SOAT1) is an endoplasmic reticulum (ER) resident, multi-transmembrane enzyme that belongs to the membrane-bound O-acyltransferase (MBOAT) family. ...
Sterol O-acyltransferase 1 (SOAT1) is an endoplasmic reticulum (ER) resident, multi-transmembrane enzyme that belongs t
Sterol O-Acyltransferase 2 Contributes to the Yolk Cholesterol Trafficking during Zebrafish Embryogenesis.
Chang NY, Chan YJ, Ding ST, Lee YH, HuangFu WC, Liu IH. Chang NY, et al. PLoS One. 2016 Dec 9;11(12):e0167644. doi: 10.1371/journal.pone.0167644. eCollection 2016. PLoS One. 2016. PMID: 27936201 Free PMC article.
To elucidate whether Sterol O-acyltransferase (Soat) mediates the absorption and transportation of yolk lipids to the developing embryo, zebrafish soat1 and soat2 were cloned and studied. ...
To elucidate whether Sterol O-acyltransferase (Soat) mediates the absorption and transportation of yolk lipids to the d …
New Terpendole Congeners, Inhibitors of Sterol O-Acyltransferase, Produced by Volutella citrinella BF-0440.
Nur EAA, Kobayashi K, Amagai A, Ohshiro T, Tomoda H. Nur EAA, et al. Molecules. 2020 Jul 6;25(13):3079. doi: 10.3390/molecules25133079. Molecules. 2020. PMID: 32640743 Free PMC article.
Compounds 2 and 3 had 7 and 6 consecutive ring systems with an indole ring, respectively, whereas 1 had a unique indolinone plus 4 consecutive ring system. Compounds 2 and 3 inhibited both sterol O-acyltransferase 1 and 2 isozymes, but 1 lost the inhibitory a …
Compounds 2 and 3 had 7 and 6 consecutive ring systems with an indole ring, respectively, whereas 1 had a unique indolinone plus 4 consecuti …
7-Chlorofolipastatin, an inhibitor of sterol O-acyltransferase, produced by marine-derived Aspergillus ungui NKH-007.
Uchida R, Nakajyo K, Kobayashi K, Ohshiro T, Terahara T, Imada C, Tomoda H. Uchida R, et al. J Antibiot (Tokyo). 2016 Aug;69(8):647-51. doi: 10.1038/ja.2016.27. Epub 2016 Mar 16. J Antibiot (Tokyo). 2016. PMID: 26980608
The structure of 7-chlorofolipastatin was elucidated by various spectroscopic data including 1D and 2D NMR spectroscopy. 7-Chlorofolipastatin inhibited sterol O-acyltransferase (SOAT) 1 and 2 isozymes in cell-based and enzyme assays using SOAT1- and SOAT2-exp …
The structure of 7-chlorofolipastatin was elucidated by various spectroscopic data including 1D and 2D NMR spectroscopy. 7-Chlorofolipastati …
Heterologous Biosynthesis of the Sterol O-Acyltransferase Inhibitor Helvamide Unveils an alpha-Ketoglutarate-Dependent Cross-Linking Oxygenase.
Wang R, Liang JJ, Yang W, Vuong D, Kalaitzis JA, Lacey AE, Lacey E, Piggott AM, Chooi YH, Li H. Wang R, et al. Org Lett. 2024 Mar 8;26(9):1807-1812. doi: 10.1021/acs.orglett.3c04310. Epub 2024 Feb 23. Org Lett. 2024. PMID: 38393343
We have identified the biosynthetic gene cluster (hvm) for the sterol O-acyltransferase inhibitor helvamide (1) from the genome of Aspergillus rugulosus MST-FP2007. ...
We have identified the biosynthetic gene cluster (hvm) for the sterol O-acyltransferase inhibitor helvamide (1) from th …
Callyspongiamides A and B, sterol O-acyltransferase inhibitors, from the Indonesian marine sponge Callyspongia sp.
Kapojos MM, Abdjul DB, Yamazaki H, Ohshiro T, Rotinsulu H, Wewengkang DS, Sumilat DA, Tomoda H, Namikoshi M, Uchida R. Kapojos MM, et al. Bioorg Med Chem Lett. 2018 Jun 1;28(10):1911-1914. doi: 10.1016/j.bmcl.2018.03.077. Epub 2018 Mar 30. Bioorg Med Chem Lett. 2018. PMID: 29631961
Callyspongiamides A (1) and B (2), two new sterol O-acyltransferase (SOAT) inhibitors, were isolated from the Indonesian marine sponge Callyspongia sp. together with a known congener, dysamide A (3). ...
Callyspongiamides A (1) and B (2), two new sterol O-acyltransferase (SOAT) inhibitors, were isolated from the Indonesia …
Clonoamide, a new inhibitor of sterol O-acyltransferase, produced by Clonostachys sp. BF-0131.
Kobayashi K, Tsukasaki N, Uchida R, Yamaguchi Y, Tomoda H. Kobayashi K, et al. J Antibiot (Tokyo). 2015 Oct;68(10):615-9. doi: 10.1038/ja.2015.37. Epub 2015 Apr 22. J Antibiot (Tokyo). 2015. PMID: 25899123
BF-0131 by solvent extraction, Diaion HP20 column chromatography, octadecylsilyl column chromatography and preparative HPLC as an inhibitor of sterol O-acyltransferase (SOAT). The structure of clonoamide was elucidated as 2-oxo-9E,11E-tridecandienyl acetamide …
BF-0131 by solvent extraction, Diaion HP20 column chromatography, octadecylsilyl column chromatography and preparative HPLC as an inhibitor …
Celludinones, new inhibitors of sterol O-acyltransferase, produced by Talaromyces cellulolyticus BF-0307.
Ohshiro T, Seki R, Fukuda T, Uchida R, Tomoda H. Ohshiro T, et al. J Antibiot (Tokyo). 2018 Nov;71(12):1000-1007. doi: 10.1038/s41429-018-0097-0. Epub 2018 Sep 3. J Antibiot (Tokyo). 2018. PMID: 30177721
Celludinone A was found to be a mixture of racemic isomers (()-1), which were isolated by a chiral column. Compounds (+)-1 and (-)-1 inhibited the sterol O-acyltransferase (SOAT) 1 and 2 isozymes in a cell-based assay using SOAT1- and SOAT2-expressing Chinese …
Celludinone A was found to be a mixture of racemic isomers (()-1), which were isolated by a chiral column. Compounds (+)-1 and (-)-1 inhibit …
The Anti-atherogenic Activity of Beauveriolide Derivative BVD327, a Sterol O-Acyltransferase 2-Selective Inhibitor, in Apolipoprotein E Knockout Mice.
Ohshiro T, Imuta S, Hijikuro I, Yagyu H, Takahashi T, Doi T, Ishibashi S, Tomoda H. Ohshiro T, et al. Biol Pharm Bull. 2020;43(6):951-958. doi: 10.1248/bpb.b19-00913. Biol Pharm Bull. 2020. PMID: 32475917 Free article.
The fungal 13-membered cyclodepsipeptides, beauveriolides I and III, were previously reported to be atheroprotective activity in mouse models via inhibiting sterol O-acyltransferase (SOAT) activity. A total of 149 beauveriolide derivatives (BVDs) synthesized …
The fungal 13-membered cyclodepsipeptides, beauveriolides I and III, were previously reported to be atheroprotective activity in mouse model …
3,879 results