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Suppression of STAT3 by S31-201 to reduce the production of immunoinhibitory cytokines in a HIF1-alpha-dependent manner: a study on the MCF-7 cell line.
Jahangiri A, Dadmanesh M, Ghorban K. Jahangiri A, et al. In Vitro Cell Dev Biol Anim. 2018 Dec;54(10):743-748. doi: 10.1007/s11626-018-0299-6. Epub 2018 Oct 12. In Vitro Cell Dev Biol Anim. 2018. PMID: 30315441
The main aim of this study was to inhibit STAT3 and HIF-1alpha and assess their effects on the expression of immunosuppressive cytokines. S31-201 and PX-478 were used to inhibit STAT3 and HIF-1alpha, respectively. ...Supernatant levels were also measured for VEGF, I …
The main aim of this study was to inhibit STAT3 and HIF-1alpha and assess their effects on the expression of immunosuppressive cytokines. …
Targeting DCLK1 attenuates tumor stemness and evokes antitumor immunity in triple-negative breast cancer by inhibiting IL-6/STAT3 signaling.
Liu H, Yan R, Xiao Z, Huang X, Yao J, Liu J, An G, Ge Y. Liu H, et al. Breast Cancer Res. 2023 Apr 17;25(1):43. doi: 10.1186/s13058-023-01642-3. Breast Cancer Res. 2023. PMID: 37069669 Free PMC article.
Inhibiting IL-6/STAT3 pathway by IL-6R antagonist, Tocilizumab or STAT3 inhibitor, S31-201 could abolish DCLK1-promoted malignant phenotypes of TNBC cells. ...
Inhibiting IL-6/STAT3 pathway by IL-6R antagonist, Tocilizumab or STAT3 inhibitor, S31-201 could abolish DCLK1-promoted malign …
IL-6/STAT3 Is a Promising Therapeutic Target for Hepatocellular Carcinoma.
Xu J, Lin H, Wu G, Zhu M, Li M. Xu J, et al. Front Oncol. 2021 Dec 15;11:760971. doi: 10.3389/fonc.2021.760971. eCollection 2021. Front Oncol. 2021. PMID: 34976809 Free PMC article. Review.
Recent, some inhibitors of IL-6/STAT3 have been development, such as S31-201 or IL-6 neutralizing monoclonal antibody (IL-6 mAb), Madindoline A (Inhibits the dimerization of IL-6/IL-6R/gpl30 trimeric complexes), C188-9 and Curcumin (Inhibits STAT3 phosphorylation), …
Recent, some inhibitors of IL-6/STAT3 have been development, such as S31-201 or IL-6 neutralizing monoclonal antibody (IL-6 mA …
The Characteristics of Human iPS Cells and siRNA Transfection Under Hypoxia.
Sugimoto K, Hayashi Y. Sugimoto K, et al. Methods Mol Biol. 2022;2454:657-664. doi: 10.1007/7651_2020_299. Methods Mol Biol. 2022. PMID: 32567017
Furthermore, we introduce the change of HIF-2alpha expression when signal transducer and activator of transcription 3 (STAT3) is suppressed by its inhibitor, Stattic or S31 201, using RT-PCR....
Furthermore, we introduce the change of HIF-2alpha expression when signal transducer and activator of transcription 3 (STAT3) is suppressed …
microRNA-17-5p downregulation inhibits autophagy and myocardial remodelling after myocardial infarction by targeting STAT3.
Chen B, Yang Y, Wu J, Song J, Lu J. Chen B, et al. Autoimmunity. 2022 Feb;55(1):43-51. doi: 10.1080/08916934.2021.1992754. Epub 2021 Nov 10. Autoimmunity. 2022. PMID: 34755577
Then, after inhibiting STAT3 expression using STAT3 inhibitor S31-201, the fibrosis, scarring, and cardiomyocyte apoptosis were deteriorated, along with the rise of LC3-II/LC3-I and Beclin-1 expression, the reduction of p62 expression and the reversion of MI attenua …
Then, after inhibiting STAT3 expression using STAT3 inhibitor S31-201, the fibrosis, scarring, and cardiomyocyte apoptosis wer …
VSIG4 Attenuates NLRP3 and Ameliorates Neuroinflammation via JAK2-STAT3-A20 Pathway after Intracerebral Hemorrhage in Mice.
Ji N, Wu L, Shi H, Li Q, Yu A, Yang Z. Ji N, et al. Neurotox Res. 2022 Feb;40(1):78-88. doi: 10.1007/s12640-021-00456-5. Epub 2022 Jan 11. Neurotox Res. 2022. PMID: 35013905
Ad-VSIG4 or controls were administered via intracerebroventricular (i.c.v) injection before ICH induction. STAT3 inhibitor (S31-201), JAK2 inhibitor (TG101348), or Ad-A20 RNAi was administered to investigate the role of JAK2-STAT3-A20 pathway in VSIG4-mediated neuro …
Ad-VSIG4 or controls were administered via intracerebroventricular (i.c.v) injection before ICH induction. STAT3 inhibitor (S31-20 …
MiRNA-155 regulates lymphangiogenesis in natural killer/T-cell lymphoma by targeting BRG1.
Chang Y, Cui M, Fu X, Zhang L, Li X, Li L, Wu J, Sun Z, Zhang X, Li Z, Nan F, Yan J, Zhang M. Chang Y, et al. Cancer Biol Ther. 2019;20(1):31-41. doi: 10.1080/15384047.2018.1504721. Epub 2018 Oct 9. Cancer Biol Ther. 2019. PMID: 30299211 Free PMC article.
The critical role of miR-155 and STAT3 was assessed using miR-155 inhibitor and STAT3 inhibitor S31-201, respectively. Two biological phenotypes, apoptosis and pro-lymphangiogenesis, were examined in vitro by flow cytometry and lymphatic tube formation, respectively …
The critical role of miR-155 and STAT3 was assessed using miR-155 inhibitor and STAT3 inhibitor S31-201, respectively. Two bio …
ERK1/2/mTOR/Stat3 pathway-mediated autophagy alleviates traumatic brain injury-induced acute lung injury.
Xu X, Zhi T, Chao H, Jiang K, Liu Y, Bao Z, Fan L, Wang D, Li Z, Liu N, Ji J. Xu X, et al. Biochim Biophys Acta Mol Basis Dis. 2018 May;1864(5 Pt A):1663-1674. doi: 10.1016/j.bbadis.2018.02.011. Epub 2018 Feb 18. Biochim Biophys Acta Mol Basis Dis. 2018. PMID: 29466698 Free article.
Extracellular signal-regulated kinase 1/2 (ERK1/2) inhibitor U0126, mechanistic target of rapamycin (mTOR) inhibitor rapamycin, and signal transducer and activator of transcription 3 (Stat3) inhibitor S31-201 were used to test the role of ERK1/2/mTOR/Stat3 signaling …
Extracellular signal-regulated kinase 1/2 (ERK1/2) inhibitor U0126, mechanistic target of rapamycin (mTOR) inhibitor rapamycin, and signal t …
Metformin Combined with 4SC-202 Inhibited the Migration and Invasion of OSCC via STAT3/TWIST1.
He Y, Fan Z, He L, Zhang C, Ping F, Deng M, Liu S, Wang Y, Cheng B, Xia J. He Y, et al. Onco Targets Ther. 2020 Oct 29;13:11019-11029. doi: 10.2147/OTT.S268851. eCollection 2020. Onco Targets Ther. 2020. PMID: 33149616 Free PMC article.
METHODS: Human OSCC cell lines HSC6 and CAL33 were cultured with metformin (16 mM) or/and 4SC-202 (0.4 muM) for 72 h. STAT3 inhibitor S31-201 was applied at concentration of 60 muM for 48 h. Wound-healing assays and transwell assays were used to determine the invasi …
METHODS: Human OSCC cell lines HSC6 and CAL33 were cultured with metformin (16 mM) or/and 4SC-202 (0.4 muM) for 72 h. STAT3 inhibitor S31 …
Effects of hypoxia inducible factors on pluripotency in human iPS cells.
Sugimoto K, Matsuura T, Nakazono A, Igawa K, Yamada S, Hayashi Y. Sugimoto K, et al. Microsc Res Tech. 2018 Jul;81(7):749-754. doi: 10.1002/jemt.23032. Epub 2018 Apr 6. Microsc Res Tech. 2018. PMID: 29633433
Furthermore, the expression of HIF-2alpha was decreased when signal transducer and activator of transcription 3 (STAT3) was suppressed by its inhibitor, Stattic or S31 201. The inhibition using Stattic did not produce colony formation. The expression of pluripotent …
Furthermore, the expression of HIF-2alpha was decreased when signal transducer and activator of transcription 3 (STAT3) was suppressed by it …
27 results