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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1970 1
1972 2
1974 2
1975 13
1976 12
1977 11
1978 12
1979 14
1980 16
1981 16
1982 15
1983 7
1984 12
1985 19
1986 15
1987 7
1988 20
1989 12
1990 9
1991 16
1992 12
1993 9
1994 13
1995 9
1996 8
1997 11
1998 9
1999 5
2000 6
2001 9
2002 14
2003 11
2004 12
2005 12
2006 14
2007 13
2008 10
2009 11
2010 10
2011 9
2012 11
2013 13
2014 7
2015 7
2016 8
2017 11
2018 6
2019 2
2020 1
2021 7
2022 8
2023 5
2024 1

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497 results

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Page 1
Histamine N-Methyltransferase in the Brain.
Yoshikawa T, Nakamura T, Yanai K. Yoshikawa T, et al. Int J Mol Sci. 2019 Feb 10;20(3):737. doi: 10.3390/ijms20030737. Int J Mol Sci. 2019. PMID: 30744146 Free PMC article. Review.
Previous studies have shown the involvement of histamine depletion in several neurological disorders, indicating the importance of drug development targeting the brain histamine system. Histamine N-methyltransferase (HNMT) is a histamine-metabolising enzyme e …
Previous studies have shown the involvement of histamine depletion in several neurological disorders, indicating the importance of drug deve …
Inhibition of Astrocytic Histamine N-Methyltransferase as a Possible Target for the Treatment of Alzheimer's Disease.
Flores-Clemente C, Nicolás-Vázquez MI, Mera Jiménez E, Hernández-Rodríguez M. Flores-Clemente C, et al. Biomolecules. 2021 Sep 26;11(10):1408. doi: 10.3390/biom11101408. Biomolecules. 2021. PMID: 34680041 Free PMC article. Review.
The increase of histamine levels can be achieved by inhibiting its degrading enzyme, histamine N-methyltransferase (HNMT), a cytoplasmatic enzyme located in astrocytes. ...
The increase of histamine levels can be achieved by inhibiting its degrading enzyme, histamine N-methyltransferase (HNM …
Histamine and histamine intolerance.
Maintz L, Novak N. Maintz L, et al. Am J Clin Nutr. 2007 May;85(5):1185-96. doi: 10.1093/ajcn/85.5.1185. Am J Clin Nutr. 2007. PMID: 17490952 Free article. Review.
It has been proposed that DAO, when functioning as a secretory protein, may be responsible for scavenging extracellular histamine after mediator release. Conversely, histamine N-methyltransferase, the other important enzyme inactivating histamine, is a cytoso …
It has been proposed that DAO, when functioning as a secretory protein, may be responsible for scavenging extracellular histamine after medi …
Contribution of astrocytic histamine N-methyltransferase to histamine clearance and brain function in mice.
Otsuka R, Naganuma F, Nakamura T, Miwa H, Nakayama-Naono R, Matsuzawa T, Komatsu Y, Sato Y, Takahashi Y, Tatsuoka-Kitano H, Yanai K, Yoshikawa T. Otsuka R, et al. Neuropharmacology. 2022 Jul 1;212:109065. doi: 10.1016/j.neuropharm.2022.109065. Epub 2022 Apr 26. Neuropharmacology. 2022. PMID: 35487272
Brain histamine acts as a neurotransmitter in the regulation of various brain activities. Previous studies have shown that histamine N-methyltransferase (HNMT), a histamine-metabolizing enzyme, controls brain histamine concentration and brain function. ...
Brain histamine acts as a neurotransmitter in the regulation of various brain activities. Previous studies have shown that histamine …
Brain Histamine N-Methyltransferase As a Possible Target of Treatment for Methamphetamine Overdose.
Kitanaka J, Kitanaka N, Hall FS, Uhl GR, Takemura M. Kitanaka J, et al. Drug Target Insights. 2016 Mar 2;10:1-7. doi: 10.4137/DTI.S38342. eCollection 2016. Drug Target Insights. 2016. PMID: 26966348 Free PMC article. Review.
There is increasing evidence that elevated levels of brain histamine can attenuate METH-induced behavioral abnormalities, which might therefore constitute a novel therapeutic treatment for METH abuse and METH overdose. In mammals, histamine N-methyltransferase …
There is increasing evidence that elevated levels of brain histamine can attenuate METH-induced behavioral abnormalities, which might theref …
Methylation pharmacogenetics: catechol O-methyltransferase, thiopurine methyltransferase, and histamine N-methyltransferase.
Weinshilboum RM, Otterness DM, Szumlanski CL. Weinshilboum RM, et al. Annu Rev Pharmacol Toxicol. 1999;39:19-52. doi: 10.1146/annurev.pharmtox.39.1.19. Annu Rev Pharmacol Toxicol. 1999. PMID: 10331075 Review.
Pharmacogenetic studies of methyltransferase enzymes have resulted in the identification and characterization of functionally important common genetic polymorphisms for catechol O-methyltransferase, thiopurine methyltransferase, and histamine N-methyltransferase …
Pharmacogenetic studies of methyltransferase enzymes have resulted in the identification and characterization of functionally important comm …
Metoprine, a histamine N-methyltransferase inhibitor, attenuates methamphetamine-induced hyperlocomotion via activation of histaminergic neurotransmission in mice.
Kitanaka N, Hall FS, Kobori S, Kushihara S, Oyama H, Sasaoka Y, Takechi M, Tanaka KI, Tomita K, Igarashi K, Nishiyama N, Sato T, Uhl GR, Kitanaka J. Kitanaka N, et al. Pharmacol Biochem Behav. 2021 Oct;209:173257. doi: 10.1016/j.pbb.2021.173257. Epub 2021 Aug 19. Pharmacol Biochem Behav. 2021. PMID: 34418452
Metoprine increases the content of histamine in brain by inhibiting histamine N-methyltransferase (HMT), a centrally acting histamine degrading enzyme. ...
Metoprine increases the content of histamine in brain by inhibiting histamine N-methyltransferase (HMT), a centrally ac …
Histamine N-methyltransferase regulates aggression and the sleep-wake cycle.
Naganuma F, Nakamura T, Yoshikawa T, Iida T, Miura Y, Kárpáti A, Matsuzawa T, Yanai A, Mogi A, Mochizuki T, Okamura N, Yanai K. Naganuma F, et al. Sci Rep. 2017 Nov 21;7(1):15899. doi: 10.1038/s41598-017-16019-8. Sci Rep. 2017. PMID: 29162912 Free PMC article.
Recent studies have reported that histaminergic dysfunction in the brain is associated with neuropsychiatric disorders. Histamine N-methyltransferase (HNMT) is an enzyme expressed in the central nervous system that specifically metabolises histamine; yet, the …
Recent studies have reported that histaminergic dysfunction in the brain is associated with neuropsychiatric disorders. Histamine …
Sexually Dimorphic Effects of Histamine Degradation by Enteric Glial Histamine N-Methyltransferase (HNMT) on Visceral Hypersensitivity.
McClain JL, Morales-Soto W, Gonzales J, Parmar V, Demireva EY, Gulbransen BD. McClain JL, et al. Biomolecules. 2023 Nov 14;13(11):1651. doi: 10.3390/biom13111651. Biomolecules. 2023. PMID: 38002333 Free PMC article.
Here, we show that enteric glia contribute to histamine clearance in the enteric nervous system (ENS) through their expression of the enzyme histamine N-methyltransferase (HNMT). Glial HNMT expression was initially assessed using immunolabeling and gene expre …
Here, we show that enteric glia contribute to histamine clearance in the enteric nervous system (ENS) through their expression of the enzyme …
497 results