Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1976 1
1977 1
1981 1
1984 1
1986 2
1997 1
1998 1
1999 2
2000 2
2004 1
2005 1
2007 1
2009 1
2011 1
2016 1
2017 1
2019 1
2020 5
2021 1
2023 1
2024 0

Text availability

Article attribute

Article type

Publication date

Search Results

27 results

Results by year

Filters applied: . Clear all
Quoted phrase not found in phrase index: "Bleomycin B4"
Page 1
Leukotriene B4 mediates macrophage influx and pulmonary hypertension in bleomycin-induced chronic neonatal lung injury.
Ee MT, Kantores C, Ivanovska J, Wong MJ, Jain A, Jankov RP. Ee MT, et al. Am J Physiol Lung Cell Mol Physiol. 2016 Aug 1;311(2):L292-302. doi: 10.1152/ajplung.00120.2016. Epub 2016 Jun 17. Am J Physiol Lung Cell Mol Physiol. 2016. PMID: 27317685 Free article.
Bleomycin led to increased lung content of LTB4, but not cysteinyl LTs. Bleomycin-induced increases in tissue neutrophils and macrophages and lung contents of LTB4 and tumor necrosis factor-alpha were all prevented by treatment with zileuton. ...
Bleomycin led to increased lung content of LTB4, but not cysteinyl LTs. Bleomycin-induced increases in tissue neutrophils and …
Effects of a leukotriene B4 receptor antagonist on bleomycin-induced pulmonary fibrosis.
Izumo T, Kondo M, Nagai A. Izumo T, et al. Eur Respir J. 2009 Dec;34(6):1444-51. doi: 10.1183/09031936.00143708. Epub 2009 May 21. Eur Respir J. 2009. PMID: 19460787 Free article.
In this study, we investigated whether ONO-4057, a LTB(4) receptor (BLTR) antagonist is capable of preventing bleomycin-induced pulmonary fibrosis. On day 1, C57BL/6 male mice were given a single intratracheal injection of bleomycin (2.5 mg x kg(-1)), and ONO-4057 ( …
In this study, we investigated whether ONO-4057, a LTB(4) receptor (BLTR) antagonist is capable of preventing bleomycin-induced pulmo …
Anemoside B4 Protects against Acute Lung Injury by Attenuating Inflammation through Blocking NLRP3 Inflammasome Activation and TLR4 Dimerization.
Yuan R, He J, Huang L, Du LJ, Gao H, Xu Q, Yang S. Yuan R, et al. J Immunol Res. 2020 Dec 3;2020:7502301. doi: 10.1155/2020/7502301. eCollection 2020. J Immunol Res. 2020. PMID: 33344657 Free PMC article.
Co-IP and molecular docking results illustrated that B4 disrupted the dimerization of TLR4. For in vivo results, B4 exhibited a protective effect on LPS and bleomycin- (BLM-) induced ALI in mice through suppressing the lesions of lung tissues, the release of …
Co-IP and molecular docking results illustrated that B4 disrupted the dimerization of TLR4. For in vivo results, B4 exhibited …
Bleomycin stimulates lung epithelial cells to release neutrophil and monocyte chemotactic activities.
Sato E, Koyama S, Masubuchi T, Takamizawa A, Kubo K, Nagai S, Izumi T. Sato E, et al. Am J Physiol. 1999 Jun;276(6):L941-50. doi: 10.1152/ajplung.1999.276.6.L941. Am J Physiol. 1999. PMID: 10362718
Although bleomycin, an antineoplastic drug, is used in the treatment of a variety of tumors, the mechanisms of bleomycin-induced lung injury and fibrosis are not fully elucidated. ...Immunoreactive leukotriene B4 receptor, interleukin-8, granulocyte colony-st …
Although bleomycin, an antineoplastic drug, is used in the treatment of a variety of tumors, the mechanisms of bleomycin-induc …
Bleomycin stimulates lung fibroblast and epithelial cell lines to release eosinophil chemotactic activity.
Sato E, Koyama S, Robbins RA. Sato E, et al. Eur Respir J. 2000 Nov;16(5):951-8. Eur Respir J. 2000. PMID: 11153598 Free article.
HFL-1 and BEAS-2B cells were cultured in the presence of bleomycin and their supernatant fluids evaluated for ECA by means of a Boyden chamber method. ...In both cases, the release of GM-CSF was significantly increased in response to bleomycin. These data suggest th …
HFL-1 and BEAS-2B cells were cultured in the presence of bleomycin and their supernatant fluids evaluated for ECA by means of a Boyde …
BLT1 Mediates Bleomycin-Induced Lung Fibrosis Independently of Neutrophils and CD4+ T Cells.
Lv J, Xiong Y, Li W, Yang W, Zhao L, He R. Lv J, et al. J Immunol. 2017 Feb 15;198(4):1673-1684. doi: 10.4049/jimmunol.1600465. Epub 2017 Jan 11. J Immunol. 2017. PMID: 28077599
In this study, we demonstrated that BLT1(-/-) mice exhibited significantly attenuated bleomycin (BLM)-induced lung fibrosis. Interestingly, BLT1 blockade with its specific antagonist U75302 in the acute injury phase (days 0-10 after BLM treatment) significantly attenuated …
In this study, we demonstrated that BLT1(-/-) mice exhibited significantly attenuated bleomycin (BLM)-induced lung fibrosis. Interest …
Bleomycin stimulates lung fibroblasts to release neutrophil and monocyte chemotactic activity.
Takamizawa A, Koyama S, Sato E, Masubuchi T, Kubo K, Sekiguchi M, Nagai S, Izumi T. Takamizawa A, et al. J Immunol. 1999 May 15;162(10):6200-8. J Immunol. 1999. PMID: 10229865
Molecular sieve column chromatography revealed that both NCA and MCA had multiple chemotactic peaks. NCA was inhibited by leukotriene B4 receptor antagonist and anti-IL-8 and G-CSF Abs. MCA was attenuated by leukotriene B4 receptor antagonist, and monocyte chemoattr …
Molecular sieve column chromatography revealed that both NCA and MCA had multiple chemotactic peaks. NCA was inhibited by leukotriene B4 …
Exercise Improves Lung Inflammation, but Not Lung Remodeling and Mechanics in a Model of Bleomycin-Induced Lung Fibrosis.
El-Mafarjeh E, Martins GHC, Probst JJ, Santos-Dias A, Oliveira-Junior MC, de Barros MP, de Oliveira LVF, de Andrade LD, da Palma RK, Moraes-Ferreira R, de Camargo Hizume-Kunzler D, Bachi ALL, Vieira RP. El-Mafarjeh E, et al. Oxid Med Cell Longev. 2020 Oct 16;2020:4302608. doi: 10.1155/2020/4302608. eCollection 2020. Oxid Med Cell Longev. 2020. PMID: 33123311 Free PMC article.
INTRODUCTION: Moderate aerobic exercise training accelerates the resolution of lung fibrosis in a model of bleomycin-induced pulmonary fibrosis. However, whether it can inhibit the development of lung fibrosis is unknown. MATERIALS AND METHODS: C57Bl/6 mice were distribute …
INTRODUCTION: Moderate aerobic exercise training accelerates the resolution of lung fibrosis in a model of bleomycin-induced pulmonar …
Isolation and preliminary characterization of bleomycin-resistant mutants from Chinese hamster ovary cells.
Akiyama S, Kuwano M. Akiyama S, et al. J Cell Physiol. 1981 Apr;107(1):147-53. doi: 10.1002/jcp.1041070116. J Cell Physiol. 1981. PMID: 6163788
Bleomycin-A2-resistant cell lines exhibited increased resistance to bleomycin analogs--bleomycin-A5, -B2, -B4, and pepleomycin. Colchicine, mitomycin C, and ultraviolet light irradiation inhibited colony formation equally in CHO cells and in bleomyc …
Bleomycin-A2-resistant cell lines exhibited increased resistance to bleomycin analogs--bleomycin-A5, -B2, -B4, a …
Fibroblast MMP14-Dependent Collagen Processing Is Necessary for Melanoma Growth.
Pach E, Brinckmann J, Rübsam M, Kümper M, Mauch C, Zigrino P. Pach E, et al. Cancers (Basel). 2021 Apr 20;13(8):1984. doi: 10.3390/cancers13081984. Cancers (Basel). 2021. PMID: 33924099 Free PMC article.
In line with these data, in vitro melanoma cell growth was inhibited in high collagen 3D spheroids or stiff substrates. Most importantly, in vivo induction of fibrosis using bleomycin reduced melanoma tumor growth. In summary, we show that MMP14 expression in stromal fibro …
In line with these data, in vitro melanoma cell growth was inhibited in high collagen 3D spheroids or stiff substrates. Most importantly, in …
27 results