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1969 1
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A third class of anti-arrhythmic action. Effects on atrial and ventricular intracellular potentials, and other pharmacological actions on cardiac muscle, of MJ 1999 and AH 3474.
Singh BN, Vaughan Williams EM. Singh BN, et al. Br J Pharmacol. 1970 Aug;39(4):675-87. doi: 10.1111/j.1476-5381.1970.tb09893.x. Br J Pharmacol. 1970. PMID: 5485144 Free PMC article.
1. Both MJ 1999 and AH 3474 protected guinea-pigs anaesthetized with urethane against ouabain-induced ventricular fibrillation.2. MJ 1999 had 1/90, and AH 3474 1/30, of the activity of procaine in reducing the height of the action potential of frog sci …
1. Both MJ 1999 and AH 3474 protected guinea-pigs anaesthetized with urethane against ouabain-induced ventricular fibrillation …
N-Aralkyl substitution increases the affinity of adrenergic drugs for the alpha-adrenoceptor in rat liver.
Aggerbeck M, Guellaën G, Hanoune J. Aggerbeck M, et al. Br J Pharmacol. 1979 Jan;65(1):155-9. doi: 10.1111/j.1476-5381.1979.tb17344.x. Br J Pharmacol. 1979. PMID: 216448 Free PMC article.
This result might be due to its bulky substituent on the amino group. 2 Further displacement experiments between [3H]-DHEC and four pairs of drugs differently substituted on the amino group (isoprenaline vs Cc-25, orciprenaline vs fenoterol, AH 3474 vs labetalol, pi …
This result might be due to its bulky substituent on the amino group. 2 Further displacement experiments between [3H]-DHEC and four pairs of …