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4'-O-Methylalpinumisoflavone inhibits the activation of monocytes/macrophages to an immunostimulatory phenotype induced by 27-hydroxycholesterol.
Lee J, Kim BY, Son Y, Giang DH, Lee D, Eo SK, Kim K. Lee J, et al. Int J Mol Med. 2019 May;43(5):2177-2186. doi: 10.3892/ijmm.2019.4135. Epub 2019 Mar 18. Int J Mol Med. 2019. PMID: 30896858
However, whether flavonoids affect the deleterious biological activity of oxygenated cholesterol molecules remains to be elucidated. The present study investigated the effects of 4'-O-methylalpinumisoflavone (mAI) isolated from Maclura tricuspidata (Cudrania …
However, whether flavonoids affect the deleterious biological activity of oxygenated cholesterol molecules remains to be elucidated. The pre …
Invariom structure refinement, electrostatic potential and toxicity of 4-O-methylalpinumisoflavone, O,O-dimethylalpinumisoflavone and 5-O-methyl-4-O-(3-methylbut-2-en-1-yl)alpinumisoflavone.
Kingsford-Adaboh R, Dittrich B, Hübschle CB, Gbewonyo WS, Okamoto H, Kimura M, Ishida H. Kingsford-Adaboh R, et al. Acta Crystallogr B. 2006 Oct;62(Pt 5):843-9. doi: 10.1107/S0108768106019616. Epub 2006 Sep 18. Acta Crystallogr B. 2006. PMID: 16983165
The accurate X-ray single-crystal structures of the isoflavone compounds 4-O-methylalpinumisoflavone, O,O-dimethylalpinumisoflavone and 5-O-methyl-4-O-(3-methylbut-2-en-1-yl)alpinumisoflavone {alpinumisoflavone = 5-hydroxy-7-(4-hydroxyphenyl)-2,2-dimethyl-2H, …
The accurate X-ray single-crystal structures of the isoflavone compounds 4-O-methylalpinumisoflavone, O,O-dimethylalpin …
Nepetifoliol - a new glutinane-triterpenoid from Leonotis nepetifolia.
Nguyen TK, Ton TQ, Ngo TT, Phan TT, Nguyen TL, Nguyen KP, Nguyen TH. Nguyen TK, et al. Nat Prod Res. 2023 Jan;37(2):256-262. doi: 10.1080/14786419.2021.1963244. Epub 2021 Aug 9. Nat Prod Res. 2023. PMID: 34365866
Compounds (2), (3) and some previously reported ones, isolated from this extract, including 5alpha-stigmasta-22-ene-3-one (4), friedelin (5), chrysophanol (6), physcion (7), and 4'-O-methylalpinumisoflavone (8) were evaluated for their alpha-glucosidase inhib …
Compounds (2), (3) and some previously reported ones, isolated from this extract, including 5alpha-stigmasta-22-ene-3-one (4), friedelin (5) …
Urease inhibitory isoflavonoids from different parts of Calopogonium mucunoides (Fabaceae).
Ndemangou B, Sielinou VT, Vardamides JC, Ali MS, Lateef M, Iqbal L, Afza N, Nkengfack AE. Ndemangou B, et al. J Enzyme Inhib Med Chem. 2013 Dec;28(6):1156-61. doi: 10.3109/14756366.2012.719025. Epub 2012 Oct 11. J Enzyme Inhib Med Chem. 2013. PMID: 23057815
The dichloromethane-methanol (1:1) soluble part of Calopogonium mucunoides (Fabaceae) resulted in the isolation of 10 isoflavones (4'-O-methylalpinumisoflavone, 4'-O-methylderrone, alpinumisoflavone, daidzeine, Calopogonium isoflavone A, atalantoflavone, 2',4 …
The dichloromethane-methanol (1:1) soluble part of Calopogonium mucunoides (Fabaceae) resulted in the isolation of 10 isoflavones (4' …
Lupin pyranoisoflavones inhibiting hyphal development in arbuscular mycorrhizal fungi.
Akiyama K, Tanigawa F, Kashihara T, Hayashi H. Akiyama K, et al. Phytochemistry. 2010 Nov;71(16):1865-71. doi: 10.1016/j.phytochem.2010.08.010. Epub 2010 Aug 31. Phytochemistry. 2010. PMID: 20813384
Four known pyranoisoflavones, licoisoflavone B (1), sophoraisoflavone A (2), alpinumisoflavone (3) and 3'-hydroxy-4'-O-methylalpinumisoflavone (4), together with three previously unknown pyranoisoflavones, lupindipyranoisoflavone A (5), 10'-hydroxylicoisoflav …
Four known pyranoisoflavones, licoisoflavone B (1), sophoraisoflavone A (2), alpinumisoflavone (3) and 3'-hydroxy-4'-O-meth …
Methylalpinumisoflavone inhibits lipopolysaccharide-induced inflammation in microglial cells by the NF-kappaB and MAPK signaling pathway.
Lim JY, Hwang BY, Hwang KW, Park SY. Lim JY, et al. Phytother Res. 2012 Dec;26(12):1948-56. doi: 10.1002/ptr.4810. Epub 2012 Aug 16. Phytother Res. 2012. PMID: 22899404
In this study, we investigated the anti-inflammatory effects of 4'-O-methylalpinumisoflavone (methylalpinumisoflavone), isolated from Cudrania tricuspidata, against LPS-induced microglial activation in BV2 cells. ...
In this study, we investigated the anti-inflammatory effects of 4'-O-methylalpinumisoflavone (methylalpinumisoflavone), …
Methylalpinumisoflavone inhibits hypoxia-inducible factor-1 (HIF-1) activation by simultaneously targeting multiple pathways.
Liu Y, Veena CK, Morgan JB, Mohammed KA, Jekabsons MB, Nagle DG, Zhou YD. Liu Y, et al. J Biol Chem. 2009 Feb 27;284(9):5859-68. doi: 10.1074/jbc.M806744200. Epub 2008 Dec 17. J Biol Chem. 2009. PMID: 19091749 Free PMC article.
Bioassay-guided isolation of an active lipid extract of the tropical legumaceous plant Lonchocarpus glabrescens and structure elucidation afforded two new HIF-1 inhibitors: alpinumisoflavone (compound 1) and 4'-O-methylalpinumisoflavone (compound 2). In human …
Bioassay-guided isolation of an active lipid extract of the tropical legumaceous plant Lonchocarpus glabrescens and structure elucidation af …
Monoamine oxidase inhibitory constituents from the fruits of Cudrania tricuspidata.
Han XH, Hong SS, Hwang JS, Jeong SH, Hwang JH, Lee MH, Lee MK, Lee D, Ro JS, Hwang BY. Han XH, et al. Arch Pharm Res. 2005 Dec;28(12):1324-7. doi: 10.1007/BF02977895. Arch Pharm Res. 2005. PMID: 16392662
Three known prenylated isoflavones were isolated and identified by activity-guided fractionation. Gancaonin A (1), 4'-O-methylalpinumisoflavone (2), and alpinumisoflavone (3) inhibited MAO activity in a concentration-dependent manner with IC50 values of 19.4, …
Three known prenylated isoflavones were isolated and identified by activity-guided fractionation. Gancaonin A (1), 4'-O-met …
Two new isoflavone derivatives from the roots of an Egyptian collection of Lotus polyphyllos.
Abdel-Kader MS, Amer ME, Tang S, Kingston DG. Abdel-Kader MS, et al. Nat Prod Res. 2006 Aug;20(10):922-6. doi: 10.1080/14786410500364627. Nat Prod Res. 2006. PMID: 16854720
Investigation of the roots of Lotus polyphyllos Clarke resulted in the isolation of two new isoflavone derivatives; 4'-O-methylerythrinin C (3) and 4'-O-methyl-2''-hydroxydihydroalpinumisoflavone (4). In addition, the three known isoflavone derivatives 4'-O-methy …
Investigation of the roots of Lotus polyphyllos Clarke resulted in the isolation of two new isoflavone derivatives; 4'-O-methylerythrinin C …