Identification and biochemical characterization of halisulfate 3 and suvanine as novel inhibitors of hepatitis C virus NS3 helicase from a marine sponge.
Furuta A, Salam KA, Hermawan I, Akimitsu N, Tanaka J, Tani H, Yamashita A, Moriishi K, Nakakoshi M, Tsubuki M, Peng PW, Suzuki Y, Yamamoto N, Sekiguchi Y, Tsuneda S, Noda N.
Furuta A, et al.
Mar Drugs. 2014 Jan 21;12(1):462-76. doi: 10.3390/md12010462.
Mar Drugs. 2014.
PMID: 24451189
Free PMC article.
Both hal3 and suvanine inhibited the ATPase, RNA binding, and serine protease activities of NS3 helicase with IC50 values of 8, 8, and 14 M, and 7, 3, and 34 M, respectively. However, the dengue virus (DENV) NS3 helicase, which shares a catalytic core (consisting mainly of …
Both hal3 and suvanine inhibited the ATPase, RNA binding, and serine protease activities of NS3 helicase with IC50 values of 8, 8, an …