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Suvanine analogs from a Coscinoderma sp. marine sponge and their cytotoxicities against human cancer cell lines.
Lee JW, Lee HS, Shin J, Kang JS, Yun J, Shin HJ, Lee JS, Lee YJ. Lee JW, et al. Arch Pharm Res. 2015 Jun;38(6):1005-10. doi: 10.1007/s12272-014-0479-1. Epub 2014 Sep 17. Arch Pharm Res. 2015. PMID: 25224406
Nine suvanine analogs including suvanine phenethylammonium salt and two new compounds were isolated from the marine sponge Coscinoderma sp., collected from Chuuk State, Federated States of Micronesia. The structures of the new compounds were elucidated by 2D NMR and …
Nine suvanine analogs including suvanine phenethylammonium salt and two new compounds were isolated from the marine sponge Cos …
Suvanine sesterterpenes and deacyl irciniasulfonic acids from a tropical Coscinoderma sp. sponge.
Kim CK, Song IH, Park HY, Lee YJ, Lee HS, Sim CJ, Oh DC, Oh KB, Shin J. Kim CK, et al. J Nat Prod. 2014 Jun 27;77(6):1396-403. doi: 10.1021/np500156n. Epub 2014 May 14. J Nat Prod. 2014. PMID: 24828374
On the basis of the results of combined spectroscopic and chemical analyses, a new suvanine salt was determined to be the suvanine N,N-dimethyl-1,3-dimethylherbipoline salt (2) and suvanine-lactam derivatives (4-8) formed by condensations between an oxidized …
On the basis of the results of combined spectroscopic and chemical analyses, a new suvanine salt was determined to be the suvanine …
Suvanine sesterterpenes from a tropical sponge Coscinoderma sp. inhibit isocitrate lyase in the glyoxylate cycle.
Lee SH, Won TH, Kim H, Ahn CH, Shin J, Oh KB. Lee SH, et al. Mar Drugs. 2014 Oct 10;12(10):5148-59. doi: 10.3390/md12105148. Mar Drugs. 2014. PMID: 25310766 Free PMC article.
Mutants of Candida albicans lacking ICL are markedly less virulent in mice than the wild-type. Suvanine sesterterpenes (1-9) isolated from a tropical sponge Coscinoderma sp. were evaluated for their inhibitory activities toward recombinant ICL from C. albicans. These studi …
Mutants of Candida albicans lacking ICL are markedly less virulent in mice than the wild-type. Suvanine sesterterpenes (1-9) isolated …
Identification and biochemical characterization of halisulfate 3 and suvanine as novel inhibitors of hepatitis C virus NS3 helicase from a marine sponge.
Furuta A, Salam KA, Hermawan I, Akimitsu N, Tanaka J, Tani H, Yamashita A, Moriishi K, Nakakoshi M, Tsubuki M, Peng PW, Suzuki Y, Yamamoto N, Sekiguchi Y, Tsuneda S, Noda N. Furuta A, et al. Mar Drugs. 2014 Jan 21;12(1):462-76. doi: 10.3390/md12010462. Mar Drugs. 2014. PMID: 24451189 Free PMC article.
Both hal3 and suvanine inhibited the ATPase, RNA binding, and serine protease activities of NS3 helicase with IC50 values of 8, 8, and 14 M, and 7, 3, and 34 M, respectively. However, the dengue virus (DENV) NS3 helicase, which shares a catalytic core (consisting mainly of …
Both hal3 and suvanine inhibited the ATPase, RNA binding, and serine protease activities of NS3 helicase with IC50 values of 8, 8, an …
Binding mechanism of the farnesoid X receptor marine antagonist suvanine reveals a strategy to forestall drug modulation on nuclear receptors. Design, synthesis, and biological evaluation of novel ligands.
Di Leva FS, Festa C, D'Amore C, De Marino S, Renga B, D'Auria MV, Novellino E, Limongelli V, Zampella A, Fiorucci S. Di Leva FS, et al. J Med Chem. 2013 Jun 13;56(11):4701-17. doi: 10.1021/jm400419e. Epub 2013 May 24. J Med Chem. 2013. PMID: 23656455
Here, we report suvanine, a marine sponge sesterterpene, as an antagonist of the mammalian bile acid sensor farnesoid-X-receptor (FXR). Using suvanine as a template, we shed light on the molecular bases of FXR antagonism, identifying the essential conformational cha …
Here, we report suvanine, a marine sponge sesterterpene, as an antagonist of the mammalian bile acid sensor farnesoid-X-receptor (FXR …
Isolation of 1-Methylherbipoline Salts of Halisulfate-1 and of Suvanine as Serine Protease Inhibitors from a Marine Sponge, Coscinoderma mathewsi.
Kimura J, Ishizuka E, Nakao Y, Yoshida WY, Scheuer PJ, Kelly-Borges M. Kimura J, et al. J Nat Prod. 1998 Feb 27;61(2):248-50. doi: 10.1021/np970376z. J Nat Prod. 1998. PMID: 9548853
Bioassay-guided isolation of serine protease inhibitors from a marine sponge, Coscinoderma mathewsi, has yielded 1-methylherbipoline salts of halisulfate-1 and of suvanine. Structures of these compounds were identified by spectroscopic analyses and literature data. ...
Bioassay-guided isolation of serine protease inhibitors from a marine sponge, Coscinoderma mathewsi, has yielded 1-methylherbipoline salts o …
Chemical proteomics reveals heat shock protein 60 to be the main cellular target of the marine bioactive sesterterpene suvanine.
Cassiano C, Monti MC, Festa C, Zampella A, Riccio R, Casapullo A. Cassiano C, et al. Chembiochem. 2012 Sep 3;13(13):1953-8. doi: 10.1002/cbic.201200291. Epub 2012 Jul 24. Chembiochem. 2012. PMID: 22829539
The identification of their cellular targets is crucial for a rational approach to their application in medicinal chemistry. Thus, we have analyzed the cell interactome of suvanine, a sulfated tricyclic terpenoid of marine origin endowed with an interesting anti-inflammato …
The identification of their cellular targets is crucial for a rational approach to their application in medicinal chemistry. Thus, we have a …
Sesterterpenes from the tropical sponge Coscinoderma sp.
Bae J, Jeon JE, Lee YJ, Lee HS, Sim CJ, Oh KB, Shin J. Bae J, et al. J Nat Prod. 2011 Aug 26;74(8):1805-11. doi: 10.1021/np200492k. Epub 2011 Aug 9. J Nat Prod. 2011. PMID: 21827183
On the basis of the results of combined spectroscopic analyses, the new compounds were determined to be derivatives of the halisulfates and suvanine. These compounds exhibited moderate cytotoxicity against the K562 cell line and inhibitory activities against isocitrate lya …
On the basis of the results of combined spectroscopic analyses, the new compounds were determined to be derivatives of the halisulfates and …