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Single dose oral pharmacokinetic profile rubraxanthone in mice.
Susanti M, Darmianti R, Harahap Y, Itam A, Hamidi D. Susanti M, et al. Heliyon. 2022 Mar 14;8(3):e09104. doi: 10.1016/j.heliyon.2022.e09104. eCollection 2022 Mar. Heliyon. 2022. PMID: 35342834 Free PMC article.
Rubraxanthone is a main active constituent of kandis (Garcinia cowa Roxb), has showed many biological activity including antimicrobial, anti hypercholesterolemic, antiplatelet, antioxidant, cytotoxic, and anti-inflammatory properties. To the best of our knowledge, no repor …
Rubraxanthone is a main active constituent of kandis (Garcinia cowa Roxb), has showed many biological activity including antimicrobia …
Promising SARS-CoV-2 main protease inhibitor ligand-binding modes evaluated using LB-PaCS-MD/FMO.
Hengphasatporn K, Harada R, Wilasluck P, Deetanya P, Sukandar ER, Chavasiri W, Suroengrit A, Boonyasuppayakorn S, Rungrotmongkol T, Wangkanont K, Shigeta Y. Hengphasatporn K, et al. Sci Rep. 2022 Oct 26;12(1):17984. doi: 10.1038/s41598-022-22703-1. Sci Rep. 2022. PMID: 36289271 Free PMC article.
LB-PaCS-MD/FMO is a hybrid ligand-binding evaluation method elucidating how rubraxanthone interacts with SARS-CoV-2 M(pro). In the first step, LB-PaCS-MD, which is regarded as a flexible docking, efficiently samples a set of ligand-binding pathways. ...The interaction prof …
LB-PaCS-MD/FMO is a hybrid ligand-binding evaluation method elucidating how rubraxanthone interacts with SARS-CoV-2 M(pro). In the fi …
A Comprehensive Review of the Phytochemical and Pharmacological Potential of an Evergreen Plant Garcinia cowa.
Chouni A, Paul S. Chouni A, et al. Chem Biodivers. 2023 Feb;20(2):e202200910. doi: 10.1002/cbdv.202200910. Epub 2023 Jan 23. Chem Biodivers. 2023. PMID: 36628555 Review.
Reported secondary metabolites are enriched with xanthones, phloroglucinols, depsidones, steroids, etc. alpha-mangostin, beta-mangostin, cowaxanthone, rubraxanthone, cowanin, norcowanin, etc. represent the major xanthones. ...
Reported secondary metabolites are enriched with xanthones, phloroglucinols, depsidones, steroids, etc. alpha-mangostin, beta-mangostin, cow …
Mangostanaxanthone VIII, a new xanthone from Garcinia mangostana and its cytotoxic activity.
Ibrahim SRM, Abdallah HM, El-Halawany AM, Nafady AM, Mohamed GA. Ibrahim SRM, et al. Nat Prod Res. 2019 Jan;33(2):258-265. doi: 10.1080/14786419.2018.1446012. Epub 2018 Mar 7. Nat Prod Res. 2019. PMID: 29513040
A new prenylated xanthone, mangostanaxanthone VIII (7) and six known metabolites: gartanin (1), 1,3,8-trihydroxy-2-(3-methyl-2-butenyl)-4-(3-hydroxy-3-methylbutanoyl)-xanthone (2), rubraxanthone (3), 1,3,6,7-tetrahydroxy-8-prenylxanthone (4), garcinone C (5), and xanthone …
A new prenylated xanthone, mangostanaxanthone VIII (7) and six known metabolites: gartanin (1), 1,3,8-trihydroxy-2-(3-methyl-2-butenyl)-4-(3 …
Cytotoxicity and nitric oxide inhibitory activities of Xanthones isolated from Calophyllum hosei Ridl.
Daud S, Karunakaran T, Santhanam R, Nagaratnam SR, Jong VYM, Ee GCL. Daud S, et al. Nat Prod Res. 2021 Dec;35(24):6067-6072. doi: 10.1080/14786419.2020.1819273. Epub 2020 Sep 9. Nat Prod Res. 2021. PMID: 32901512
Phytochemical investigations carried out on the plant, Calophyllum hosei led to the isolation of eleven known xanthones, ananixanthone (1), 9-hydroxycalabaxanthone (2), dombakinaxanthone (3), thwaitesixanthone (4), caloxanthone B (5), trapezifolixanthone (6), beta-mangostin (7), …
Phytochemical investigations carried out on the plant, Calophyllum hosei led to the isolation of eleven known xanthones, ananixanthone (1), …
A new xanthone from Garcinia nitida.
Ee GC, Foo CH, Jong VY, Ismail NH, Sukari MA, Taufiq Yap YH, Awang K. Ee GC, et al. Nat Prod Res. 2012;26(9):830-5. doi: 10.1080/14786419.2011.559640. Epub 2011 Nov 1. Nat Prod Res. 2012. PMID: 22044165 Free article.
They are 1,6-dihydroxy-5-methoxy-6,6-dimethylpyrano[2',3':2,3]-xanthone (1), inophyllin B (2), osajaxanthone (3), 3-isomangostin (4) and rubraxanthone (5). The structures of these compounds were established using mainly 1-D and 2-D NMR spectroscopy ((1)H, (13)C, DEPT, COSY …
They are 1,6-dihydroxy-5-methoxy-6,6-dimethylpyrano[2',3':2,3]-xanthone (1), inophyllin B (2), osajaxanthone (3), 3-isomangostin (4) and …
Cytotoxic Properties and Complete Nuclear Magnetic Resonance Assignment of Isolated Xanthones from the Root of Garcinia cowa Roxb.
Wahyuni FS, Shaari K, Stanslas J, Lajis NH, Hamidi D. Wahyuni FS, et al. Pharmacogn Mag. 2016 Jan;12(Suppl 1):S52-6. doi: 10.4103/0973-1296.176115. Pharmacogn Mag. 2016. PMID: 27041859 Free PMC article.
RESULTS: Phytochemical study on the roots of G. cowa yielded rubraxanthone (3), cowanine (4) and 1,5-dihydroxyxanthone (5). Compound 4 with an IC50 value of 4.1 1.0 muM, 5.4 2.3 muM and 11.3 10.0 muM against MCF-7, H-460, and DU-145, respectively while compound 3 was found …
RESULTS: Phytochemical study on the roots of G. cowa yielded rubraxanthone (3), cowanine (4) and 1,5-dihydroxyxanthone (5). Compound …
High Performance Thin layer Chromatography: Densitometry Method for Determination of Rubraxanthone in the Stem Bark Extract of Garcinia cowa Roxb.
Hamidi D, Aulia H, Susanti M. Hamidi D, et al. Pharmacognosy Res. 2017 Jul-Sep;9(3):230-233. doi: 10.4103/pr.pr_144_16. Pharmacognosy Res. 2017. PMID: 28827962 Free PMC article.
The spots were observed at ultraviolet 243 nm. RESULTS: The linearity of rubraxanthone was obtained between 52.5 and 157.5 ppm/spot. The LOD and LOQ were found to be 4.03 and 13.42 ppm/spot, respectively. CONCLUSION: The proposed method showed good linearity, precision, ac …
The spots were observed at ultraviolet 243 nm. RESULTS: The linearity of rubraxanthone was obtained between 52.5 and 157.5 ppm/spot. …
In vitro inhibitory effect of rubraxanthone isolated from Garcinia parvifolia on platelet-activating factor receptor binding.
Jantan I, Pisar MM, Idris MS, Taher M, Ali RM. Jantan I, et al. Planta Med. 2002 Dec;68(12):1133-4. doi: 10.1055/s-2002-36343. Planta Med. 2002. PMID: 12494345
Rubraxanthone and isocowanol isolated from Garcinia parvifolia Miq. were investigated for their inhibitory effects on platelet-activating factor (PAF) binding to rabbit platelets using 3H-PAF as a ligand. Rubraxanthone showed a strong inhibition with IC 50 value of …
Rubraxanthone and isocowanol isolated from Garcinia parvifolia Miq. were investigated for their inhibitory effects on platelet-activa …
Cytotoxicity of prenylated xanthones and other constituents from the wood of Garcinia merguensis.
Kijjoa A, Gonzalez MJ, Pinto MM, Nascimento MS, Campos N, Mondranondra IO, Silva AM, Eaton G, Herz W. Kijjoa A, et al. Planta Med. 2008 Jun;74(8):864-6. doi: 10.1055/s-2008-1074544. Epub 2008 Jun 3. Planta Med. 2008. PMID: 18523924
One new prenylated xanthone 5-farnesyltoxyloxanthone B ( 4), three known xanthones alpha-mangostin ( 1), rubraxanthone ( 2) and isocowanol ( 3) as well as (2 E,6 E,10 E)-4beta-hydroxy-3-methyl-5beta-(3,7,11,15-tetramethylhexadeca-2,6,10-tetraenyl)-cyclohex-2-en-1-one ( 5) …
One new prenylated xanthone 5-farnesyltoxyloxanthone B ( 4), three known xanthones alpha-mangostin ( 1), rubraxanthone ( 2) and isoco …
20 results