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1999 4
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85 results

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Page 1
Simvastatin inhibits POVPC-mediated induction of endothelial-to-mesenchymal cell transition.
Li Y, Zhang YX, Ning DS, Chen J, Li SX, Mo ZW, Peng YM, He SH, Chen YT, Zheng CJ, Gao JJ, Yuan HX, Ou JS, Ou ZJ. Li Y, et al. J Lipid Res. 2021;62:100066. doi: 10.1016/j.jlr.2021.100066. Epub 2021 Mar 10. J Lipid Res. 2021. PMID: 33711324 Free PMC article.
Whether POVPC promotes EndMT and how simvastatin influences POVPC-mediated EndMT remains unclear. ...POVPC also decreased NO production and expression of CD31 and endothelial NO synthase. ...
Whether POVPC promotes EndMT and how simvastatin influences POVPC-mediated EndMT remains unclear. ...POVPC also decreas …
The oxidized phospholipid POVPC impairs endothelial function and vasodilation via uncoupling endothelial nitric oxide synthase.
Yan FX, Li HM, Li SX, He SH, Dai WP, Li Y, Wang TT, Shi MM, Yuan HX, Xu Z, Zhou JG, Ning DS, Mo ZW, Ou ZJ, Ou JS. Yan FX, et al. J Mol Cell Cardiol. 2017 Nov;112:40-48. doi: 10.1016/j.yjmcc.2017.08.016. Epub 2017 Sep 1. J Mol Cell Cardiol. 2017. PMID: 28870504
However, whether POVPC promotes atherosclerosis like 25-hydroxycholesterol remains unclear. The purpose of this study was to explore the effects of POVPC on endothelial function and vasodilation. Human umbilical vein endothelial cells (HUVECs) were incubated with …
However, whether POVPC promotes atherosclerosis like 25-hydroxycholesterol remains unclear. The purpose of this study was to explore …
Oxidized phospholipid POVPC contributes to vascular calcification by triggering ferroptosis of vascular smooth muscle cells.
Lu L, Ye Y, Chen Y, Feng L, Huang J, Liang Q, Lan Z, Dong Q, Liu X, Li Y, Zhang X, Ou JS, Chen A, Yan J. Lu L, et al. FASEB J. 2024 Apr 15;38(7):e23592. doi: 10.1096/fj.202302570R. FASEB J. 2024. PMID: 38581243
In addition, POVPC treatment increased expression of osteogenic markers Runx2 and BMP2, indicating that POVPC promotes osteogenic transition of VSMCs. ...Furthermore, ferrostatin-1 attenuated POVPC-induced calcification of VSMCs. Taken together, our study for …
In addition, POVPC treatment increased expression of osteogenic markers Runx2 and BMP2, indicating that POVPC promotes osteoge …
The Levels of Oxidized Phospholipids in High-Density Lipoprotein During the Course of Sepsis and Their Prognostic Value.
Li Z, Luo Z, Shi X, Pang B, Ma Y, Jin J. Li Z, et al. Front Immunol. 2022 May 3;13:893929. doi: 10.3389/fimmu.2022.893929. eCollection 2022. Front Immunol. 2022. PMID: 35592322 Free PMC article.
RESULTS: Septic patients exhibited significant increase of HDL-POVPC at day 1, 3 and 7 after sepsis onset (POVPC-D1, p=0.0004; POVPC-D3, p=0.033; POVPC-D7, p=0.004, versus controls). ...Furthermore, HDL-POVPC level in non-survivors was significa …
RESULTS: Septic patients exhibited significant increase of HDL-POVPC at day 1, 3 and 7 after sepsis onset (POVPC-D1, p=0.0004; …
Oxidized phospholipid: POVPC binds to platelet-activating-factor receptor on human macrophages. Implications in atherosclerosis.
Pégorier S, Stengel D, Durand H, Croset M, Ninio E. Pégorier S, et al. Atherosclerosis. 2006 Oct;188(2):433-43. doi: 10.1016/j.atherosclerosis.2005.11.015. Epub 2005 Dec 28. Atherosclerosis. 2006. PMID: 16386258
We show that, POVPC binds to cultured human macrophages via PAF-R and transduces the signals leading to the intracellular Ca(2+) fluxes and modifies the transcription levels of numerous pro-inflammatory and pro-atherogenic genes. Although a some similarity of the gene expr …
We show that, POVPC binds to cultured human macrophages via PAF-R and transduces the signals leading to the intracellular Ca(2+) flux …
The oxidized phospholipids POVPC and PGPC inhibit growth and induce apoptosis in vascular smooth muscle cells.
Fruhwirth GO, Moumtzi A, Loidl A, Ingolic E, Hermetter A. Fruhwirth GO, et al. Biochim Biophys Acta. 2006 Sep;1761(9):1060-9. doi: 10.1016/j.bbalip.2006.06.001. Epub 2006 Jul 4. Biochim Biophys Acta. 2006. PMID: 16904371
The aim of this study was to elicit the type and outcome of the cellular response of vascular smooth muscle cells (VSMC) upon treatment with POVPC and PGPC. Both oxidized phospholipids led to inhibition of cell proliferation and showed cytotoxic effects in VSMC. ...Thus, t …
The aim of this study was to elicit the type and outcome of the cellular response of vascular smooth muscle cells (VSMC) upon treatment with …
Partial Mitigation of Oxidized Phospholipid-Mediated Mitochondrial Dysfunction in Neuronal Cells by Oxocarotenoids.
Ademowo OS, Dias IHK, Diaz-Sanchez L, Sanchez-Aranguren L, Stahl W, Griffiths HR. Ademowo OS, et al. J Alzheimers Dis. 2020;74(1):113-126. doi: 10.3233/JAD-190923. J Alzheimers Dis. 2020. PMID: 31985464
Co-incubation with oxocarotenoids prevented loss of GSH after 1 muM but not 20 muM POVPC, whereas the increase in ROS production induced by 20 muM POVPC was prevented by lutein and zeaxanthin. ...In summary, 20 muM POVPC induced loss of GSH and a mitochondria …
Co-incubation with oxocarotenoids prevented loss of GSH after 1 muM but not 20 muM POVPC, whereas the increase in ROS production indu …
Phospholipid oxidation and carotenoid supplementation in Alzheimer's disease patients.
Ademowo OS, Dias HKI, Milic I, Devitt A, Moran R, Mulcahy R, Howard AN, Nolan JM, Griffiths HR. Ademowo OS, et al. Free Radic Biol Med. 2017 Jul;108:77-85. doi: 10.1016/j.freeradbiomed.2017.03.008. Epub 2017 Mar 14. Free Radic Biol Med. 2017. PMID: 28315450 Free PMC article.
AD patients (n=21) and healthy age-matched control subjects (n=16) were supplemented with either Macushield (10mg meso-zeaxanthin, 10mg lutein, 2mg zeaxanthin) or placebo (sunflower oil) for six months. The MRM-MS method determined serum POVPC sensitively (from 10l serum) …
AD patients (n=21) and healthy age-matched control subjects (n=16) were supplemented with either Macushield (10mg meso-zeaxanthin, 10mg lute …
Oxidized phosphatidylcholines trigger ferroptosis in cardiomyocytes during ischemia-reperfusion injury.
Stamenkovic A, O'Hara KA, Nelson DC, Maddaford TG, Edel AL, Maddaford G, Dibrov E, Aghanoori M, Kirshenbaum LA, Fernyhough P, Aliani M, Pierce GN, Ravandi A. Stamenkovic A, et al. Am J Physiol Heart Circ Physiol. 2021 Mar 1;320(3):H1170-H1184. doi: 10.1152/ajpheart.00237.2020. Epub 2021 Jan 29. Am J Physiol Heart Circ Physiol. 2021. PMID: 33513080 Free article.
POVPC and PONPC also caused a significant decrease in Ca(2+) transients and net contraction in isolated cardiomyocytes compared to vehicle treated control cells (P < 0.05). ...However, glutathione peroxidase 4 activity was markedly suppressed in cardiomyocytes treated w …
POVPC and PONPC also caused a significant decrease in Ca(2+) transients and net contraction in isolated cardiomyocytes compared to ve …
Oxidized Phospholipids in Tumor Microenvironment Stimulate Tumor Metastasis via Regulation of Autophagy.
Seok JK, Hong EH, Yang G, Lee HE, Kim SE, Liu KH, Kang HC, Cho YY, Lee HS, Lee JY. Seok JK, et al. Cells. 2021 Mar 4;10(3):558. doi: 10.3390/cells10030558. Cells. 2021. PMID: 33806593 Free PMC article.
POVPC induced autophagic flux through AMPK-mTOR pathway. Pharmacological inhibition or siRNA knockdown of autophagy decreased migration and invasion of POVPC-treated HepG2 and MCF7 cells. POVPC and PGPC levels were greatly increased at stage II of patient-der …
POVPC induced autophagic flux through AMPK-mTOR pathway. Pharmacological inhibition or siRNA knockdown of autophagy decreased migrati …
85 results