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Synthetic Cannabinoid Hydroxypentyl Metabolites Retain Efficacy at Human Cannabinoid Receptors.
Gamage TF, Farquhar CE, McKinnie RJ, Kevin RC, McGregor IS, Trudell ML, Wiley JL, Thomas BF. Gamage TF, et al. J Pharmacol Exp Ther. 2019 Mar;368(3):414-422. doi: 10.1124/jpet.118.254425. Epub 2018 Dec 14. J Pharmacol Exp Ther. 2019. PMID: 30552295 Free PMC article.
A large proportion of these metabolites are hydroxylated on the pentyl chain, a key substituent that determines receptor affinity and selectivity. ...
A large proportion of these metabolites are hydroxylated on the pentyl chain, a key substituent that determines receptor affinity and …
Developmental effects of cannabinoids on zebrafish larvae.
Akhtar MT, Ali S, Rashidi H, van der Kooy F, Verpoorte R, Richardson MK. Akhtar MT, et al. Zebrafish. 2013 Sep;10(3):283-93. doi: 10.1089/zeb.2012.0785. Epub 2013 Jun 22. Zebrafish. 2013. PMID: 23789728
Cannabinoids are natural or synthetic compounds related chemically to (-)-(6aR,10aR)-6,6,9-trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-ol (delta(9)-THC), the principle psychotropic constituent of the hemp plant, Cannabis sativa L. ...
Cannabinoids are natural or synthetic compounds related chemically to (-)-(6aR,10aR)-6,6,9-trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6 …
Cannabinoids in disguise: Δ9-tetrahydrocannabinol-like effects of tetramethylcyclopropyl ketone indoles.
Wiley JL, Marusich JA, Lefever TW, Grabenauer M, Moore KN, Thomas BF. Wiley JL, et al. Neuropharmacology. 2013 Dec;75:145-54. doi: 10.1016/j.neuropharm.2013.07.022. Epub 2013 Aug 2. Neuropharmacology. 2013. PMID: 23916483 Free PMC article.
., naphthoylindoles) have become legally banned, new compounds have appeared on the drug market. Two tetramethylcyclopropyl ketone indoles, UR-144 [(1-pentyl-1H-indol-3-yl)-(2,2,3,3-tetramethylcyclopropyl)methanone] and XLR-11 [(1-(5-fluoropentyl)-1H-indol-3-yl)-(2,2,3,3-t …
., naphthoylindoles) have become legally banned, new compounds have appeared on the drug market. Two tetramethylcyclopropyl ketone indoles, …
Thermolytic Degradation of Synthetic Cannabinoids: Chemical Exposures and Pharmacological Consequences.
Thomas BF, Lefever TW, Cortes RA, Grabenauer M, Kovach AL, Cox AO, Patel PR, Pollard GT, Marusich JA, Kevin RC, Gamage TF, Wiley JL. Thomas BF, et al. J Pharmacol Exp Ther. 2017 Apr;361(1):162-171. doi: 10.1124/jpet.116.238717. Epub 2017 Jan 13. J Pharmacol Exp Ther. 2017. PMID: 28087785 Free PMC article.
Some products of combustion retained high affinity at the cannabinoid 1 (CB(1)) and CB(2) receptors, were more efficacious than (-)-cis-3-[2-hydroxy-4-(1,1-dimethylheptyl)phenyl]-trans-4-(3-hydroxypropyl)cyclohexanol (CP55,940) in stimulating CB(1) receptor-mediated guanos …
Some products of combustion retained high affinity at the cannabinoid 1 (CB(1)) and CB(2) receptors, were more efficacious than (-)-cis-3-[2 …
Extraction of phthalic acid esters from soft drinks and infusions by dispersive liquid-liquid microextraction based on the solidification of the floating organic drop using a menthol-based natural deep eutectic solvent.
Ortega-Zamora C, Jiménez-Skrzypek G, González-Sálamo J, Hernández-Borges J. Ortega-Zamora C, et al. J Chromatogr A. 2021 Jun 7;1646:462132. doi: 10.1016/j.chroma.2021.462132. Epub 2021 Apr 2. J Chromatogr A. 2021. PMID: 33894455
In this work, a natural deep eutectic solvent (NADES) consisting of L-menthol and acetic acid in a 1:1 molar ratio has been applied as extraction solvent for the dispersive liquid-liquid microextraction based on the solidification of the floating organic drop (DLLME-SFO) of a gro …
In this work, a natural deep eutectic solvent (NADES) consisting of L-menthol and acetic acid in a 1:1 molar ratio has been applied as extra …
27 results