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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1971 1
1972 2
1973 1
1974 3
1975 2
1976 4
1977 5
1978 3
1979 9
1980 11
1981 10
1982 7
1983 15
1984 23
1985 18
1986 31
1987 33
1988 27
1989 22
1990 26
1991 27
1992 28
1993 37
1994 36
1995 52
1996 78
1997 95
1998 106
1999 88
2000 113
2001 99
2002 108
2003 104
2004 111
2005 122
2006 138
2007 145
2008 180
2009 181
2010 180
2011 197
2012 229
2013 265
2014 264
2015 305
2016 329
2017 317
2018 302
2019 291
2020 311
2021 299
2022 246
2023 246
2024 85

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5,418 results

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Page 1
The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells.
Yu X, Harden K, Gonzalez LC, Francesco M, Chiang E, Irving B, Tom I, Ivelja S, Refino CJ, Clark H, Eaton D, Grogan JL. Yu X, et al. Nat Immunol. 2009 Jan;10(1):48-57. doi: 10.1038/ni.1674. Epub 2008 Nov 16. Nat Immunol. 2009. PMID: 19011627
Poliovirus receptor, which is expressed on dendritic cells, bound TIGIT with high affinity. A TIGIT-Fc fusion protein inhibited T cell activation in vitro, and this was dependent on the presence of dendritic cells. The binding of poliovirus receptor to TIGIT on human …
Poliovirus receptor, which is expressed on dendritic cells, bound TIGIT with high affinity. A TIGIT-Fc fusion protein inhibited T cel …
In-depth serum proteomics reveals biomarkers of psoriasis severity and response to traditional Chinese medicine.
Xu M, Deng J, Xu K, Zhu T, Han L, Yan Y, Yao D, Deng H, Wang D, Sun Y, Chang C, Zhang X, Dai J, Yue L, Zhang Q, Cai X, Zhu Y, Duan H, Liu Y, Li D, Zhu Y, Radstake TRDJ, Balak DMW, Xu D, Guo T, Lu C, Yu X. Xu M, et al. Theranostics. 2019 Apr 13;9(9):2475-2488. doi: 10.7150/thno.31144. eCollection 2019. Theranostics. 2019. PMID: 31131048 Free PMC article.
However, comprehensive profiling of the serological proteome is challenging due to the wide range of protein concentrations in serum. Methods: To address this challenge, we developed a novel in-depth serum proteomics platform capable of analyzing the serum proteome across …
However, comprehensive profiling of the serological proteome is challenging due to the wide range of protein concentrations in serum. …
Identification of a functional peptide of a probiotic bacterium-derived protein for the sustained effect on preventing colitis.
Kaur H, Ali SA, Short SP, Williams CS, Goettel JA, Washington MK, Peek RM Jr, Acra SA, Yan F. Kaur H, et al. Gut Microbes. 2023 Dec;15(2):2264456. doi: 10.1080/19490976.2023.2264456. Epub 2023 Oct 10. Gut Microbes. 2023. PMID: 37815528 Free PMC article.
However, there is a paucity of studies to elucidate mechanisms of their functions. p40, a secretory protein, is originally isolated from a probiotic bacterium, Lactobacillus rhamnosus GG. ...Compared to full-length p40 (p40F) and p40N180, p40N120 showed simil …
However, there is a paucity of studies to elucidate mechanisms of their functions. p40, a secretory protein, is originally iso …
Novel IL-12 family members shed light on the orchestration of Th1 responses.
Brombacher F, Kastelein RA, Alber G. Brombacher F, et al. Trends Immunol. 2003 Apr;24(4):207-12. doi: 10.1016/s1471-4906(03)00067-x. Trends Immunol. 2003. PMID: 12697453 Free PMC article. Review.
Recent data also reveal potential immunostimulatory functions of p40. In addition, p40 can be covalently linked to a p35-related protein p19. ...Finally, IL-27, the latest addition to this family, is a heterodimer composed of the p40-related protein …
Recent data also reveal potential immunostimulatory functions of p40. In addition, p40 can be covalently linked to a p35-relat …
Possible Usage of p63 in Bioptic Diagnostics.
Galoczová M, Nenutil R, Coates P, Vojtěšek B. Galoczová M, et al. Klin Onkol. 2018 Winter;31(Suppl 2):27-31. doi: 10.14735/amko20182S27. Klin Onkol. 2018. PMID: 31023021 Review. English.
TP63 encodes a variety of N-and C-terminal isoforms with different expression patterns and functions. The most frequently studied are N-terminal variants DNp63 (p40) and TAp63. p40 is a characteristic basal or myopithelial cell marker of stratified epithelium and it …
TP63 encodes a variety of N-and C-terminal isoforms with different expression patterns and functions. The most frequently studied are N-term …
Np63/p40 correlates with the location and phenotype of basal/mesenchymal cancer stem-like cells in human ER(+) and HER2(+) breast cancers.
Liu Y, Nekulova M, Nenutil R, Horakova I, Appleyard MV, Murray K, Holcakova J, Galoczova M, Quinlan P, Jordan LB, Purdie CA, Vojtesek B, Thompson AM, Coates PJ. Liu Y, et al. J Pathol Clin Res. 2020 Jan;6(1):83-93. doi: 10.1002/cjp2.149. Epub 2019 Dec 6. J Pathol Clin Res. 2020. PMID: 31591823 Free PMC article.
However, the incidence of ER(+) and HER2(+) tumours that express deltaNp63/p40 is unclear and the phenotype of deltaNp63/p40(+) cells in these tumours remains uncertain. ...Consistent with tumour samples, these cells also showed a distinct location at the tumour/str …
However, the incidence of ER(+) and HER2(+) tumours that express deltaNp63/p40 is unclear and the phenotype of deltaNp63/p40(+ …
Regulation of IL-12 p40 promoter activity in primary human monocytes: roles of NF-kappaB, CCAAT/enhancer-binding protein beta, and PU.1 and identification of a novel repressor element (GA-12) that responds to IL-4 and prostaglandin E(2).
Becker C, Wirtz S, Ma X, Blessing M, Galle PR, Neurath MF. Becker C, et al. J Immunol. 2001 Sep 1;167(5):2608-18. doi: 10.4049/jimmunol.167.5.2608. J Immunol. 2001. PMID: 11509602
In the present study, we have analyzed the regulation of IL-12 p40 promoter activity in primary human monocytes in vivo. Accordingly, we analyzed the p40 promoter by in vivo footprinting in resting and activated primary human blood CD14(+) monocytes. . …
In the present study, we have analyzed the regulation of IL-12 p40 promoter activity in primary human monocytes in vivo. Accor …
Transcriptional responses of human intestinal epithelial HT-29 cells to spore-displayed p40 derived from Lacticaseibacillus rhamnosus GG.
Kang SJ, Moon JA, Son DY, Hong KW. Kang SJ, et al. BMC Microbiol. 2022 Dec 22;22(1):316. doi: 10.1186/s12866-022-02735-3. BMC Microbiol. 2022. PMID: 36550414 Free PMC article.
BACKGROUNDS: The aims of this study were to construct spore-displayed p40, a Lacticaseibacillus rhamnosus GG-derived soluble protein, using spore surface display technology and to evaluate transcriptional responses in human intestinal epithelial cells. RESULT …
BACKGROUNDS: The aims of this study were to construct spore-displayed p40, a Lacticaseibacillus rhamnosus GG-derived soluble prote …
The emerging p53 gene family.
Kaelin WG Jr. Kaelin WG Jr. J Natl Cancer Inst. 1999 Apr 7;91(7):594-8. doi: 10.1093/jnci/91.7.594. J Natl Cancer Inst. 1999. PMID: 10203277 Review.
Perturbation of p53 protein function is a common, if not universal, finding in human cancer. ...Nonetheless, data on differences between these proteins and p53 are emerging. For example, p73 is not induced by DNA damage and is not targeted for inactivation by …
Perturbation of p53 protein function is a common, if not universal, finding in human cancer. ...Nonetheless, data on differenc …
IL-12: the role of p40 versus p75.
Abdi K. Abdi K. Scand J Immunol. 2002 Jul;56(1):1-11. doi: 10.1046/j.1365-3083.2002.01101.x. Scand J Immunol. 2002. PMID: 12100467 Free article. Review.
In the following discussion, I will delineate an alternative hypothesis for the roles of the p40 and p75 proteins, suggesting specifically, that: (1) in vivo, secretion of free p40 precedes that of p75 in response to pathogens; (2) induction of p40 is …
In the following discussion, I will delineate an alternative hypothesis for the roles of the p40 and p75 proteins, suggesting …
5,418 results