Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

Search Results

3 results

Filters applied: . Clear all
Page 1
Tiopinac in rheumatoid arthritis: a three-phase dose-ranging, efficacy, and aspirin-withdrawal protocol.
Weintraub M, Francetić I, Hasday JD, Jacox RF, Atwater EC. Weintraub M, et al. Clin Pharmacol Ther. 1980 May;27(5):579-85. doi: 10.1038/clpt.1980.82. Clin Pharmacol Ther. 1980. PMID: 6989545 Clinical Trial.
The manufacturer withdrew tiopinac from investigation because of toxicity at higher doses, but with only 13 patients we found that tiopinac (up to 300 mg/day) decreased walking time, painful joints, and morning stiffness and increased grip strength (p less than 0.05 …
The manufacturer withdrew tiopinac from investigation because of toxicity at higher doses, but with only 13 patients we found that …
Tiopinac absorption, distribution, excretion, and pharmacokinetics in man and animals.
Mroszczak EJ, Lee FW. Mroszczak EJ, et al. Drug Metab Dispos. 1980 Nov-Dec;8(6):415-21. Drug Metab Dispos. 1980. PMID: 6109609
[14C]Tiopinac disposition was evaluated in man, monkey, rabbit, mouse, minipig, and rat. ...The half-life of tiopinac was 2.3 +/- 0.3 hr in man, 0.8 hr in the minipig, and 2.6 hr in the rabbit. ...
[14C]Tiopinac disposition was evaluated in man, monkey, rabbit, mouse, minipig, and rat. ...The half-life of tiopinac was 2.3 …
The anti-inflammatory and analgesic profile of 6,11-dihydrodibenzo-[b.e.]-thiepin-11-one-3-acetic acid (tiopinac).
Rooks WH 2nd, Tomolonis AJ, Maloney PJ, Roszkowski A, Wallach MB. Rooks WH 2nd, et al. Agents Actions. 1980 Jun;10(3):266-73. doi: 10.1007/BF02025946. Agents Actions. 1980. PMID: 6967686
Tiopinac exhibited antiphlogistic activity in adrenalectomized rats. ...It was inactive in the mouse hot-plate test in which opiate-like agents are active. Tiopinac, p.o., lowered yeast-induced pyrexia (130 x aspirin). Tiopinac did not have significant cardio …
Tiopinac exhibited antiphlogistic activity in adrenalectomized rats. ...It was inactive in the mouse hot-plate test in which opiate-l …