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Drug nanocrystals for cancer therapy.
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2018 May;10(3):e1499. doi: 10.1002/wnan.1499. Epub 2017 Oct 17.
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2018.
PMID: 29044971
Review.
In the last two decades, there are a lot of hydrophobic or lipophilic drugs, such as paclitaxel (PTX), camptothecin (CPT), thymectacin, busulfan, cyclosporin A, 2-devinyl-2-(1-hexyloxyethyl) pyropheophorbide (HPPH), and so on, which have been formulated into drug NCs for c …
In the last two decades, there are a lot of hydrophobic or lipophilic drugs, such as paclitaxel (PTX), camptothecin (CPT), thymectacin …
Anti-cancer ProTides: tuning the activity of BVDU phosphoramidates related to thymectacin.
McGuigan C, Thiery JC, Daverio F, Jiang WG, Davies G, Mason M.
McGuigan C, et al.
Bioorg Med Chem. 2005 May 2;13(9):3219-27. doi: 10.1016/j.bmc.2005.02.041.
Bioorg Med Chem. 2005.
PMID: 15809157
Based on our wide ranging knowledge of phosphoramidate ProTides as anti-viral agents we have tuned the lead anti-cancer agent thymectacin in the ester and amino acid regions and revealed a substantial enhancement in in vitro potency versus colon and prostate cancer cell li …
Based on our wide ranging knowledge of phosphoramidate ProTides as anti-viral agents we have tuned the lead anti-cancer agent thymectacin …
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Nanocrystals: An Approachable Delivery System for Anticancer Therapeutics.
Khairnar P, Handa M, Shukla R.
Khairnar P, et al.
Curr Drug Metab. 2022;23(8):603-615. doi: 10.2174/1389200223666220610165850.
Curr Drug Metab. 2022.
PMID: 35702775
In the last few years, many hydrophobic or lipophilic drugs like camptothecin, paclitaxel, cyclosporin, busulfan, and thymectacin have been formulated as drug nanocrystals against anticancer therapeutics. ...
In the last few years, many hydrophobic or lipophilic drugs like camptothecin, paclitaxel, cyclosporin, busulfan, and thymectacin hav …
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Novel potential anticancer naphthyl phosphoramidates of BVdU: separation of diastereoisomers and assignment of the absolute configuration of the phosphorus center.
Congiatu C, Brancale A, Mason MD, Jiang WG, McGuigan C.
Congiatu C, et al.
J Med Chem. 2006 Jan 26;49(2):452-5. doi: 10.1021/jm0509896.
J Med Chem. 2006.
PMID: 16420029
We have previously reported our SAR optimization of the anticancer agent thymectacin. Tuning of the parent ProTide structure initially involved the amino acid and, subsequently, the aromatic masking group on the phosphate moiety. ...
We have previously reported our SAR optimization of the anticancer agent thymectacin. Tuning of the parent ProTide structure initiall …
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