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363 results

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Page 1
Enzymatic reactions in teleocidin B biosynthesis.
Awakawa T. Awakawa T. J Nat Med. 2021 Jun;75(3):467-474. doi: 10.1007/s11418-021-01504-2. Epub 2021 Mar 6. J Nat Med. 2021. PMID: 33675456 Free PMC article. Review.
The teleocidin B family members are terpene indole compounds isolated from Streptomyces bacteria, and they strongly activate protein kinase C (PKC). ...The accumulated information has facilitated the identification of the enzymatic reactions in teleocidin biosynthes …
The teleocidin B family members are terpene indole compounds isolated from Streptomyces bacteria, and they strongly activate protein …
Teleocidin A2 inhibits human proteinase-activated receptor 2 signaling in tumor cells.
Stahn S, Thelen L, Albrecht IM, Bitzer J, Henkel T, Teusch NE. Stahn S, et al. Pharmacol Res Perspect. 2016 Jun 10;4(4):e00230. doi: 10.1002/prp2.230. eCollection 2016 Aug. Pharmacol Res Perspect. 2016. PMID: 28116092 Free PMC article.
Further biochemical and cell-based studies were conducted to evaluate teleocidin specificity. The antagonizing effect of teleocidin A2 was confirmed in PAR2-dependent cell migration and rearrangement of actin cytoskeleton of human breast adenocarcinoma cell line (MD …
Further biochemical and cell-based studies were conducted to evaluate teleocidin specificity. The antagonizing effect of teleocidi …
Biosynthetic studies on teleocidins in Streptomyces.
Abe I. Abe I. J Antibiot (Tokyo). 2018 Sep;71(9):763-768. doi: 10.1038/s41429-018-0069-4. Epub 2018 Jun 14. J Antibiot (Tokyo). 2018. PMID: 29904063 Review.
Teleocidin B, with its unique indolactam-terpenoid scaffold, is a potent activator of protein kinase C. This short review summarizes our recent research progress on the biosynthesis of teleocidins in Streptomyces blastmyceticus NBRC 12747. We first identified the bi …
Teleocidin B, with its unique indolactam-terpenoid scaffold, is a potent activator of protein kinase C. This short review summarizes …
Functions, Structures, and Engineering of the Teleocidin Biosynthetic Enzymes.
Mori T. Mori T. Chem Pharm Bull (Tokyo). 2023;71(3):188-197. doi: 10.1248/cpb.c22-00849. Chem Pharm Bull (Tokyo). 2023. PMID: 36858523 Free article. Review.
Teleocidins are natural products belonging to the indole alkaloid family and show potent protein kinase C activation activity. The structural feature of teleocidins is an indole-fused nine-membered lactam ring structure. ...
Teleocidins are natural products belonging to the indole alkaloid family and show potent protein kinase C activation activity. The st …
Biosynthesis of the teleocidin-type terpenoid indole alkaloids.
Awakawa T, Abe I. Awakawa T, et al. Org Biomol Chem. 2018 Jul 4;16(26):4746-4752. doi: 10.1039/c8ob00803e. Org Biomol Chem. 2018. PMID: 29774913 Review.
Teleocidin B is a terpenoid indole alkaloid with unique structures including indolactam and cyclic terpenoid, and is a strong protein kinase C activator. ...Recently, its biosynthetic enzymes were identified, and some of their crystal structures were reported. In this revi …
Teleocidin B is a terpenoid indole alkaloid with unique structures including indolactam and cyclic terpenoid, and is a strong protein …
Acute effects of 12-O-tetradecanoylphorbol-13-acetate, teleocidin B, or 2,3,7,8-tetrachlorodibenzo-p-dioxin on cultured normal human bronchial epithelial cells.
Willey JC, Saladino AJ, Ozanne C, Lechner JF, Harris CC. Willey JC, et al. Carcinogenesis. 1984 Feb;5(2):209-15. doi: 10.1093/carcin/5.2.209. Carcinogenesis. 1984. PMID: 6421503
Toxicity was assessed by clonal growth assays. Teleocidin B and TPA had similar effects on growth, morphology and enzyme activities. ...Finally, TPA and teleocidin B each caused an increase of PA and a decrease of AHH activities in both media. ...
Toxicity was assessed by clonal growth assays. Teleocidin B and TPA had similar effects on growth, morphology and enzyme activities. …
Teleocidin-producing genotype of Streptomyces clavuligerus ATCC 27064.
Pivk Lukančič P, Drčar T, Bruccoleri R, Črnugelj M, Mrak P. Pivk Lukančič P, et al. Appl Microbiol Biotechnol. 2022 Feb;106(4):1521-1530. doi: 10.1007/s00253-022-11805-5. Epub 2022 Feb 9. Appl Microbiol Biotechnol. 2022. PMID: 35138454 Free PMC article.
Given the scale of industrial use of S. clavuligerus world-wide and toxicity of teleocidins, we also discuss the environmental and safety implications and provide a method of abolishing teleocidin production without affecting productivity of CA. KEY POINTS: Early st …
Given the scale of industrial use of S. clavuligerus world-wide and toxicity of teleocidins, we also discuss the environmental and sa …
Enzymatic Formation of Indolactam Scaffold by C-N Bond-Forming Cytochrome P450 Oxidases in Teleocidin Biosynthesis.
Morita I, Mori T, Abe I. Morita I, et al. Chemistry. 2021 Feb 10;27(9):2963-2972. doi: 10.1002/chem.202003899. Epub 2020 Dec 1. Chemistry. 2021. PMID: 32996659 Review.
Teleocidins are potent protein kinase C activators, and possess a unique indole-fused nine-membered lactam structure. Teleocidin biosynthesis starts from the formation of a dipeptide by non-ribosomal peptide synthetase (NRPS), followed by oxidative C-N bond formatio …
Teleocidins are potent protein kinase C activators, and possess a unique indole-fused nine-membered lactam structure. Teleocidin …
11-Step Total Synthesis of Teleocidins B-1-B-4.
Nakamura H, Yasui K, Kanda Y, Baran PS. Nakamura H, et al. J Am Chem Soc. 2019 Jan 30;141(4):1494-1497. doi: 10.1021/jacs.8b13697. Epub 2019 Jan 15. J Am Chem Soc. 2019. PMID: 30636411 Free PMC article.
A unified and modular approach to the teleocidin B family of natural products is presented that proceeds in 11 steps and features an array of interesting strategies and methods. ...Guided by a desire to minimize concession steps, the tactical combination of C-H borylation …
A unified and modular approach to the teleocidin B family of natural products is presented that proceeds in 11 steps and features an …
363 results