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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1989 4
1990 3
1991 8
1992 6
1993 7
1994 7
1995 3
1996 5
1997 7
1998 10
1999 8
2000 8
2001 8
2002 3
2003 5
2004 7
2006 1
2007 1
2008 3
2009 4
2019 1
2020 2
2022 1
2023 1
2024 0

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112 results

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Page 1
Tedisamil: master switch of nature?
Doggrell SA. Doggrell SA. Expert Opin Investig Drugs. 2001 Jan;10(1):129-38. doi: 10.1517/13543784.10.1.129. Expert Opin Investig Drugs. 2001. PMID: 11116286 Review.
On isolated rat ventricle, tedisamil is a positive inotrope and on isolated rabbit atria, tedisamil reverses the negative inotropic effect of pinacidil. ...In heart failure patients, tedisamil reduces heart rate, but increases blood pressure. The usefulness o …
On isolated rat ventricle, tedisamil is a positive inotrope and on isolated rabbit atria, tedisamil reverses the negative inot …
Novel antiarrhythmic drugs in atrial fibrillation: focus on tedisamil.
Krishnamoorthy S, Lip GY. Krishnamoorthy S, et al. Expert Opin Investig Drugs. 2009 Aug;18(8):1191-6. doi: 10.1517/13543780903114150. Expert Opin Investig Drugs. 2009. PMID: 19604120 Review.
METHODS: Review of the literature and studies assessing the effect of tedisamil in humans and animal models with atrial arrhythmia(s). CONCLUSION: Tedisamil appears to be effective for rhythm restoration in acute-onset AF patients. The proven anti-ischemic effect wi …
METHODS: Review of the literature and studies assessing the effect of tedisamil in humans and animal models with atrial arrhythmia(s) …
Tedisamil (Solvay).
Flores NA. Flores NA. Curr Opin Investig Drugs. 2001 Jan;2(1):97-103. Curr Opin Investig Drugs. 2001. PMID: 11527020
Tedisamil, a potassium channel blocker (class III anti-arrhythmic agent)from Solvay, is in phase II trials for the potential treatment of atrial fibrillation [342434]. ...Tedisamil also rapidly terminated sustained atrial fibrillation and prevented its reinitiation …
Tedisamil, a potassium channel blocker (class III anti-arrhythmic agent)from Solvay, is in phase II trials for the potential treatmen …
Tedisamil in coronary disease: additional benefits in the therapy of atrial fibrillation?
Opie LH. Opie LH. J Cardiovasc Pharmacol Ther. 2003 Jun;8 Suppl 1:S33-7. doi: 10.1177/107424840300800105. J Cardiovasc Pharmacol Ther. 2003. PMID: 12746750 Review.
Tedisamil works acutely against atrial fibrillation. Importantly, atrial fibrillation is often caused by or related to cardiac ischemia, and conversely, ischemia is caused by the increased oxygen demand of atrial fibrillation. Hence, the double properties of tedisamil …
Tedisamil works acutely against atrial fibrillation. Importantly, atrial fibrillation is often caused by or related to cardiac ischem …
Tedisamil in a chronic canine model of atrial flutter.
Fischbach PS, Johnston PV, Friedrichs GS, Lucchesi BR. Fischbach PS, et al. J Cardiovasc Pharmacol. 1999 Aug;34(2):212-8. doi: 10.1097/00005344-199908000-00006. J Cardiovasc Pharmacol. 1999. PMID: 10445672
No significant adverse effects of tedisamil were observed. The results indicate that tedisamil is effective in interrupting and/or preventing reinduction of canine AFL, possibly by prolonging atrial refractoriness through inhibition of one or more potassium ion repo …
No significant adverse effects of tedisamil were observed. The results indicate that tedisamil is effective in interrupting an …
Tedisamil and dofetilide-induced torsades de pointes, rate and potassium dependence.
Barrett TD, Hennan JK, Fischbach PS, O'Neill BP, Driscoll EM Jr, Lucchesi BR. Barrett TD, et al. Br J Pharmacol. 2001 Apr;132(7):1493-500. doi: 10.1038/sj.bjp.0703967. Br J Pharmacol. 2001. PMID: 11264243 Free PMC article.
1. Tedisamil is a bradycardiac agent that prolongs the QT interval of the ECG and prevents cardiac arrhythmias. ...The QT interval was prolonged in a reverse rate-dependent fashion by dofetilide (3 and 30 nM) and tedisamil (0.3 and 3 microM). 3. Torsades de pointes …
1. Tedisamil is a bradycardiac agent that prolongs the QT interval of the ECG and prevents cardiac arrhythmias. ...The QT interval wa …
Antiarrhythmic properties of tedisamil (KC8857), a putative transient outward K+ current blocker.
Beatch GN, Abraham S, MacLeod BA, Yoshida NR, Walker MJ. Beatch GN, et al. Br J Pharmacol. 1991 Jan;102(1):13-8. doi: 10.1111/j.1476-5381.1991.tb12124.x. Br J Pharmacol. 1991. PMID: 2043919 Free PMC article.
Tedisamil was tested against coronary artery occlusion-induced arrhythmias in conscious animals. 2. ...Tedisamil dose-dependently lengthened the effective refractory period and prevented electrically-induced VF. ...
Tedisamil was tested against coronary artery occlusion-induced arrhythmias in conscious animals. 2. ...Tedisamil dose-dependen …
Tedisamil: a new novel antiarrhythmic.
Freestone B, Lip GY. Freestone B, et al. Expert Opin Investig Drugs. 2004 Feb;13(2):151-60. doi: 10.1517/13543784.13.2.151. Expert Opin Investig Drugs. 2004. PMID: 14996649
Solvay Pharmaceuticals is currently developing tedisamil (KC-8857), a novel antiarrhythmic with additional anti-ischaemic properties, which acts via potassium channel blockade. ...Although tedisamil has been shown to be an effective anti-ischaemic agent, with Phase …
Solvay Pharmaceuticals is currently developing tedisamil (KC-8857), a novel antiarrhythmic with additional anti-ischaemic properties, …
Tedisamil and lidocaine enhance each other's antiarrhythmic activity against ischaemia-induced arrhythmias in rats.
Sarraf G, Barrett TD, Walker MJ. Sarraf G, et al. Br J Pharmacol. 2003 Aug;139(8):1389-98. doi: 10.1038/sj.bjp.0705373. Br J Pharmacol. 2003. PMID: 12922925 Free PMC article.
Both tedisamil and lidocaine dose-dependently suppressed ischaemia-induced arrhythmias. ...Combinations of the two drugs acted synergistically such that the ED(50) for tedisamil was reduced to 0.8+/-0.2 micro mol kg(-1) min(-1) in the presence of 2 micro mol kg(-1) …
Both tedisamil and lidocaine dose-dependently suppressed ischaemia-induced arrhythmias. ...Combinations of the two drugs acted synerg …
Tedisamil blocks BK-type Ca(2+)-dependent K(+) channels and modulates action potentials in rat hippocampal neurons.
Church J, McLarnon JG. Church J, et al. Neurosci Lett. 2002 Feb 15;319(2):79-82. doi: 10.1016/s0304-3940(01)02569-1. Neurosci Lett. 2002. PMID: 11825675
Tedisamil, a bradycardic compound in heart, also acts on K(+) channels in neurons. ...The study also points to a number of effects that may contribute to the known nervous system toxicity induced by tedisamil....
Tedisamil, a bradycardic compound in heart, also acts on K(+) channels in neurons. ...The study also points to a number of effects th …
112 results