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1983 1
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Page 1
Partial agonism of taprostene at prostanoid IP receptors in vascular preparations from guinea-pig, rat, and mouse.
Chan KM, Jones RL. Chan KM, et al. J Cardiovasc Pharmacol. 2004 Jun;43(6):795-807. doi: 10.1097/00005344-200406000-00009. J Cardiovasc Pharmacol. 2004. PMID: 15167273
In contrast, taprostene interacted additively with prostaglandin E2 (PGE2), ONO-AE1-259 (selective EP2 agonist), and acetylcholine. ...Our experiments indicate that taprostene is a partial agonist at prostanoid IP receptors, and may be a lead to an IP receptor antag …
In contrast, taprostene interacted additively with prostaglandin E2 (PGE2), ONO-AE1-259 (selective EP2 agonist), and acetylcholine. . …
The Scottish-Finnish-Swedish PARTNER study of taprostene versus placebo treatment in patients with critical limb ischemia.
Belch JJ, Ray S, Rajput-Ray M, Engeset J, Fagrell B, Lepäntalo M, McKay A, Mackay IR, Ostergren J, Ruckley CV, Salenius J. Belch JJ, et al. Int Angiol. 2011 Apr;30(2):150-5. Int Angiol. 2011. PMID: 21427652 Clinical Trial.
Hence this study evaluated safety and longer term efficacy of taprostene sodium, a prostacyclin (PGI2) analogue in CLI. The aim of this study was to determine whether Taprostene sodium, a PGI2 analogue, was a safe and effective treatment for CLI. ...A total of 111 p …
Hence this study evaluated safety and longer term efficacy of taprostene sodium, a prostacyclin (PGI2) analogue in CLI. The aim of th …
Evidence for a second receptor for prostacyclin on human airway epithelial cells that mediates inhibition of CXCL9 and CXCL10 release.
Wilson SM, Sheddan NA, Newton R, Giembycz MA. Wilson SM, et al. Mol Pharmacol. 2011 Mar;79(3):586-95. doi: 10.1124/mol.110.069674. Epub 2010 Dec 20. Mol Pharmacol. 2011. PMID: 21173040
Indeed, PGI(2), taprostene, and iloprost activated both reporters whereas 15-deoxy-TIC was inert. Conversely, 15-deoxy-TIC, PGI(2), and taprostene (but not iloprost) suppressed chemokine release. Further experiments established that iloprost did not antagonize the i …
Indeed, PGI(2), taprostene, and iloprost activated both reporters whereas 15-deoxy-TIC was inert. Conversely, 15-deoxy-TIC, PGI(2), a …
Prostanoids for intermittent claudication.
Robertson L, Andras A. Robertson L, et al. Cochrane Database Syst Rev. 2013 Apr 30;(4):CD000986. doi: 10.1002/14651858.CD000986.pub3. Cochrane Database Syst Rev. 2013. PMID: 23633305 Review.
Beraprost sodium was associated with an increased incidence of drug-related adverse events. Of two studies on taprostene, the results of one in particular must be interpreted with caution due to an imbalance in walking capacity at baseline.Comprehensive, high quality data …
Beraprost sodium was associated with an increased incidence of drug-related adverse events. Of two studies on taprostene, the results …
Low doses of superoxide dismutase and a stable prostacyclin analogue protect in myocardial ischemia and reperfusion.
Ma XL, Johnson G 3rd, Lefer AM. Ma XL, et al. J Am Coll Cardiol. 1992 Jan;19(1):197-204. doi: 10.1016/0735-1097(92)90073-v. J Am Coll Cardiol. 1992. PMID: 1729334 Free article.
Taprostene (60 ng/kg per min), human superoxide dismutase (0.25 mg/kg per h), both agents together, or their vehicle, were infused intravenously in cats starting 0.5 h after occlusion of the left anterior descending coronary artery. Neither low dose taprostene nor l …
Taprostene (60 ng/kg per min), human superoxide dismutase (0.25 mg/kg per h), both agents together, or their vehicle, were infused in …
The scavenging of hydroxyl radical(.OH) by a prostacyclin analogue, taprostene.
Arroyo CM, Wade JV, Ichimori K, Nakazawa H. Arroyo CM, et al. Chem Biol Interact. 1994 Apr;91(1):29-38. doi: 10.1016/0009-2797(94)90004-3. Chem Biol Interact. 1994. PMID: 8194123
This spin trap reacted with .OH to yield an M4PO-OH spin adduct observable by Electron Paramagnetic Resonance (EPR) spectroscopy and resulted in the rate constant, k2 = 1.5 x 10(10) M-1s-1, for the reaction between .OH and Taprostene. The results show that Taprostene …
This spin trap reacted with .OH to yield an M4PO-OH spin adduct observable by Electron Paramagnetic Resonance (EPR) spectroscopy and resulte …
Distinction between relaxations induced via prostanoid EP(4) and IP(1) receptors in pig and rabbit blood vessels.
Jones RL, Chan K. Jones RL, et al. Br J Pharmacol. 2001 Sep;134(2):313-24. doi: 10.1038/sj.bjp.0704252. Br J Pharmacol. 2001. PMID: 11564649 Free PMC article.
On piglet saphenous vein, PGE(2) was 6.1, 24, 96, 138, 168 and 285 times respectively more potent than AFP-07, cicaprost, PGI(2), iloprost, carbacyclin and TEI-9063 in causing relaxation. Another prostacyclin analogue taprostene did not induce maximum relaxation (21 - 74%) …
On piglet saphenous vein, PGE(2) was 6.1, 24, 96, 138, 168 and 285 times respectively more potent than AFP-07, cicaprost, PGI(2), iloprost, …
Effects of prostacyclin and taprostene in splanchnic artery occlusion shock.
VanAntwerp DR, Hedley LR, Spires DA, Strosberg AM, Johnson G 3rd, Lefer AM. VanAntwerp DR, et al. Eicosanoids. 1991;4(1):15-20. Eicosanoids. 1991. PMID: 2059456
Taprostene significantly improved survival time and taprostene treated animals maintained post-reperfusion mean arterial blood pressure (MABP) at significantly higher values compared to rats receiving taprostene vehicle (final MABP 96 +/- 3 vs 45 +/- 3.5 mmHg …
Taprostene significantly improved survival time and taprostene treated animals maintained post-reperfusion mean arterial blood …
Effects of taprostene, a chemically stable prostacyclin analogue, in patients with ischaemic peripheral vascular disease: a placebo controlled double-blind trial.
Virgolini I, Fitscha P, O'Grady J, Barth H, Sinzinger H. Virgolini I, et al. Prostaglandins Leukot Essent Fatty Acids. 1989 Oct;38(1):31-5. doi: 10.1016/0952-3278(89)90144-0. Prostaglandins Leukot Essent Fatty Acids. 1989. PMID: 2514430 Clinical Trial.
The ankle/brachial Doppler index was unaffected by taprostene. The platelet half-life was significantly (p less than 0.05) prolonged following taprostene-infusion (72.6 +/- 9.35 vs 77.9 +/- 7.44 hours). ...Various measures of platelet function parameters followed in …
The ankle/brachial Doppler index was unaffected by taprostene. The platelet half-life was significantly (p less than 0.05) prolonged …
Endothelium and myocardial protecting actions of taprostene, a stable prostacyclin analogue, after acute myocardial ischemia and reperfusion in cats.
Johnson G 3rd, Furlan LE, Aoki N, Lefer AM. Johnson G 3rd, et al. Circ Res. 1990 May;66(5):1362-70. doi: 10.1161/01.res.66.5.1362. Circ Res. 1990. PMID: 2159389
Taprostene infusion resulted in significantly lower plasma creatine phosphokinase activities at every time from 3 to 6 hours for the MI + taprostene group compared with the MI + vehicle group and were not significantly different when compared with sham MI controls. …
Taprostene infusion resulted in significantly lower plasma creatine phosphokinase activities at every time from 3 to 6 hours for the …
62 results