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The following term was not found in PubMed: ICID2079
Page 1
Antagonism of α1-adrenoceptors by β3-adrenergic agonists: Structure-function relations of different agonists in prostate smooth muscle contraction.
Huang R, Tamalunas A, Waidelich R, Strittmatter F, Stief CG, Hennenberg M. Huang R, et al. Biochem Pharmacol. 2022 Aug;202:115148. doi: 10.1016/j.bcp.2022.115148. Epub 2022 Jun 15. Biochem Pharmacol. 2022. PMID: 35716783
Here, we examined effects of beta(3)-adrenergic agonists on contractions of human prostate tissues, including ZD7114 (without phenylethanolamine moiety), ZD2079 (phenylethanolamine backbone), BRL37344 and CL316243 (chloride-substituted phenylethanolamine deriatives). ...Al …
Here, we examined effects of beta(3)-adrenergic agonists on contractions of human prostate tissues, including ZD7114 (without phenylethanola …
Urinary tract toxicity in rats following administration of beta 3-adrenoceptor agonists.
Waghe M, Westwood R, Nunn G, Kalinowski A, Aldridge A. Waghe M, et al. Toxicol Pathol. 1999 Mar-Apr;27(2):165-70. doi: 10.1177/019262339902700203. Toxicol Pathol. 1999. PMID: 10207980
ZD7114, [(S)-4-[2-(2-hydroxy-3 phenoxypropylamine)ethoxy]-N-(2-methoxyethyl) phenoxyacetamide], and ZD2079, [(R)-N-(2-[4- (carboxymethyl)phenoxy]ethyl)-N-(beta-hydroxyphenethyl)ammonium chloride], are beta 3-adrenoceptor stimulants with selectivity for brown adipose tissue …
ZD7114, [(S)-4-[2-(2-hydroxy-3 phenoxypropylamine)ethoxy]-N-(2-methoxyethyl) phenoxyacetamide], and ZD2079, [(R)-N-(2-[4- (carboxymet …
Effects of propranolol and L-NAME on beta-adrenoceptor-mediated relaxation in rat carotid artery.
MacDonald A, McLean M, MacAulay L, Shaw AM. MacDonald A, et al. J Auton Pharmacol. 1999 Jun;19(3):145-9. doi: 10.1046/j.1365-2680.1999.00128.x. J Auton Pharmacol. 1999. PMID: 10511470
L-NAME (100 microM) significantly reduced responses to isoprenaline, lowering the slope of the CRC and reducing the maximum response. 3. The selective beta3-adrenoceptor agonists, BRL 37344 and ZD2079, also produced concentration-dependent relaxation of the arteries. ...Th …
L-NAME (100 microM) significantly reduced responses to isoprenaline, lowering the slope of the CRC and reducing the maximum response. 3. The …
Effects of the two beta3-agonists, ZD7114 and ZD2079 on 24 hour energy expenditure and respiratory quotient in obese subjects.
Buemann B, Toubro S, Astrup A. Buemann B, et al. Int J Obes Relat Metab Disord. 2000 Dec;24(12):1553-60. doi: 10.1038/sj.ijo.0801452. Int J Obes Relat Metab Disord. 2000. PMID: 11126205 Clinical Trial.
OBJECTIVE: To analyze the effect of two different beta3-adrenoceptor agonists, ZD7114 and ZD2079 on 24h energy expenditure (EE) and substrate oxidations in obese weight-stable subjects. ...RESULTS: No effects of ZD7114 were found on tested parameters whereas there was a tr …
OBJECTIVE: To analyze the effect of two different beta3-adrenoceptor agonists, ZD7114 and ZD2079 on 24h energy expenditure (EE) and s …
Rapid inhibition of ob gene expression and circulating leptin levels in lean mice by the beta 3-adrenoceptor agonists BRL 35135A and ZD2079.
Trayhurn P, Duncan JS, Rayner DV, Hardie LJ. Trayhurn P, et al. Biochem Biophys Res Commun. 1996 Nov 12;228(2):605-10. doi: 10.1006/bbrc.1996.1704. Biochem Biophys Res Commun. 1996. PMID: 8920957
The acute effect of two selective beta 3-adrenoceptor agonists, BRL 35135A and ZD2079, on the expression of the ob gene and plasma leptin levels has been examined in mice. ...
The acute effect of two selective beta 3-adrenoceptor agonists, BRL 35135A and ZD2079, on the expression of the ob gene and plasma le …
Pharmacological characteristics and species-related variations of beta 3-adrenergic receptors.
Pietri-Rouxel F, Strosberg AD. Pietri-Rouxel F, et al. Fundam Clin Pharmacol. 1995;9(3):211-8. doi: 10.1111/j.1472-8206.1995.tb00288.x. Fundam Clin Pharmacol. 1995. PMID: 7557816 Review.
This review discusses the structure and function of beta 3-AR in various species and presents new findings on a number of beta 3-AR ligands including carazolol, tertatolol and CL 316,243 which were found to be selective and potent beta 3-AR agonists and ZD 2079 and …
This review discusses the structure and function of beta 3-AR in various species and presents new findings on a number of beta 3-AR ligands …
Validity of (-)-[3H]-CGP 12177A as a radioligand for the 'putative beta4-adrenoceptor' in rat atrium.
Sarsero D, Molenaar P, Kaumann AJ. Sarsero D, et al. Br J Pharmacol. 1998 Feb;123(3):371-80. doi: 10.1038/sj.bjp.0701609. Br J Pharmacol. 1998. PMID: 9504376 Free PMC article.
High concentrations of the beta 3-adrenoceptor agonists, BRL 37344 ((RR+SS)[4-[2-[[2-(3-chlorophenyl)-2-hydroxy-ethyl]amino]propyl]phenoxy]acetic acid, 6 microM), SR 58611A (ethyl{(7S)-7-[(2R)-2-(3-chlorophenyl)-2-hydroxyethylamino]-5,6,7,8-tetrahydronaphtyl2-yloxy} acetate hydro …
High concentrations of the beta 3-adrenoceptor agonists, BRL 37344 ((RR+SS)[4-[2-[[2-(3-chlorophenyl)-2-hydroxy-ethyl]amino]propyl]phenoxy]a …
Atypical beta-adrenoceptors, different from beta 3-adrenoceptors and probably from the low-affinity state of beta 1-adrenoceptors, relax the rat isolated mesenteric artery.
Kozłowska H, Szymska U, Schlicker E, Malinowska B. Kozłowska H, et al. Br J Pharmacol. 2003 Sep;140(1):3-12. doi: 10.1038/sj.bjp.0705421. Epub 2003 Aug 4. Br J Pharmacol. 2003. PMID: 12967929 Free PMC article.
(1) We examined whether beta3- and/or atypical beta-adrenoceptors relax the rat isolated mesenteric artery. (2) Mesenteric arteries precontracted with phenylephrine were relaxed by beta-agonists with the following potencies (pD2): nonselective agonist isoprenaline (6.00)>nonco …
(1) We examined whether beta3- and/or atypical beta-adrenoceptors relax the rat isolated mesenteric artery. (2) Mesenteric arteries precontr …
Beta 1-, beta 2- and atypical beta-adrenoceptor-mediated relaxation in rat isolated aorta.
Brawley L, Shaw AM, MacDonald A. Brawley L, et al. Br J Pharmacol. 2000 Feb;129(4):637-44. doi: 10.1038/sj.bjp.0703091. Br J Pharmacol. 2000. PMID: 10683187 Free PMC article.
The order of potency of the beta-adrenoceptor agonists was (-log EC(50)): isoprenaline (6. 25)>cyanopindolol (5.59)>isoprenaline+propranolol (5.11)>CGP 12177A (4.40)>ZD 2079 (4.24)>ZM 215001 (4.07)>BRL 37344 (3.89). Relaxation to CGP 12177A and ZM …
The order of potency of the beta-adrenoceptor agonists was (-log EC(50)): isoprenaline (6. 25)>cyanopindolol (5.59)>isoprenaline+propr …
A search for presynaptic beta3-adrenoceptors in the rat.
Zelaszczyk D, Zakrzeska A, Kwolek G, Malinowska B, Schlicker E. Zelaszczyk D, et al. Fundam Clin Pharmacol. 2005 Apr;19(2):147-53. doi: 10.1111/j.1472-8206.2005.00318.x. Fundam Clin Pharmacol. 2005. PMID: 15810894
CL 316243 and another three beta3-adrenoceptor agonists (BRL 37344, ZD 2079 and CGP 12177) failed to affect the electrically evoked tritium overflow also in slices preincubated with 3H-noradrenaline and superfused in the presence of the alpha2-adrenoceptor antagonis …
CL 316243 and another three beta3-adrenoceptor agonists (BRL 37344, ZD 2079 and CGP 12177) failed to affect the electrically e …
16 results