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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1958 2
1959 2
1960 4
1961 2
1962 5
1963 14
1964 8
1965 6
1966 3
1967 11
1968 5
1969 7
1970 1
1971 3
1972 10
1973 5
1974 4
1975 3
1976 2
1977 5
1978 1
1979 3
1980 3
1981 2
1982 2
1983 3
1984 4
1986 1
1987 2
1988 5
1989 3
1990 5
1991 3
1992 6
1993 9
1994 3
1995 17
1996 21
1997 25
1998 28
1999 28
2000 29
2001 18
2002 21
2003 25
2004 17
2005 22
2006 23
2007 23
2008 24
2009 24
2010 18
2011 10
2012 13
2013 10
2014 5
2015 9
2016 8
2017 4
2018 6
2019 4
2020 3
2021 8
2022 7
2023 4
2024 3

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583 results

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Page 1
"Dilantin" overdosage.
Lucas BG. Lucas BG. Med J Aust. 1968 Oct 12;2(15):639-40. doi: 10.5694/j.1326-5377.1968.tb83055.x. Med J Aust. 1968. PMID: 4176983 No abstract available.
Sulfaphenazole reduces thermal and pressure injury severity through rapid restoration of tissue perfusion.
Turner CT, Pawluk M, Bolsoni J, Zeglinski MR, Shen Y, Zhao H, Ponomarev T, Richardson KC, West CR, Papp A, Granville DJ. Turner CT, et al. Sci Rep. 2022 Jul 23;12(1):12622. doi: 10.1038/s41598-022-16512-9. Sci Rep. 2022. PMID: 35871073 Free PMC article.
Minimizing the consequences of repeated I/R is expected to provide a protective effect against pressure injury. Sulfaphenazole (SP), an off patent sulfonamide antibiotic, is a potent CYP 2C6 and CYP 2C9 inhibitor, functioning to decrease post-ischemic vascular dysfunction …
Minimizing the consequences of repeated I/R is expected to provide a protective effect against pressure injury. Sulfaphenazole (SP), …
The optimization and characterization of functionalized sulfonamides derived from sulfaphenazole against Mycobacterium tuberculosis with reduced CYP 2C9 inhibition.
Chen H, Wang B, Li P, Yan H, Li G, Huang H, Lu Y. Chen H, et al. Bioorg Med Chem Lett. 2021 May 15;40:127924. doi: 10.1016/j.bmcl.2021.127924. Epub 2021 Mar 9. Bioorg Med Chem Lett. 2021. PMID: 33705901
In this study, a series of sulfonamide compounds was designed and synthesized through the systematic optimization of the antibacterial agent sulfaphenazole for the treatment of Mycobacterium tuberculosis (M. tuberculosis). ...
In this study, a series of sulfonamide compounds was designed and synthesized through the systematic optimization of the antibacterial agent …
A non-acidic sulfaphenazole analog demonstrating high intrinsic clearance and selectivity by canine CYP2C21.
Locuson CW, Alfaro JF, Zaya MJ, Billen D, White JA, Jones JP. Locuson CW, et al. Drug Metab Lett. 2011 Dec;5(4):253-8. doi: 10.2174/187231211798472539. Drug Metab Lett. 2011. PMID: 22423626
In contrast to human CYP2C9, non-human CYP2C enzymes do not appear to preferentially bind and metabolize anionic drugs. Using analogs of sulfaphenazole, the effect of an acidic sulfonamide group on apparent affinity and turnover rates was characterized with canine CYP2C21. …
In contrast to human CYP2C9, non-human CYP2C enzymes do not appear to preferentially bind and metabolize anionic drugs. Using analogs of …
Butyric acid inhibits oxidative stress and inflammation injury in calcium oxalate nephrolithiasis by targeting CYP2C9.
Zhou Z, Zhou X, Zhang Y, Yang Y, Wang L, Wu Z. Zhou Z, et al. Food Chem Toxicol. 2023 Aug;178:113925. doi: 10.1016/j.fct.2023.113925. Epub 2023 Jul 4. Food Chem Toxicol. 2023. PMID: 37414240
Subsequently, NaB was found to significantly reduce CYP2C9 levels in vivo and in vitro, and inhibition of CYP2C9 by Sulfaphenazole (a specific CYP2C9 inhibitor), was able to reduce ROS levels, inflammation injury, and apoptosis in oxalate-induced HK-2 cells. ...
Subsequently, NaB was found to significantly reduce CYP2C9 levels in vivo and in vitro, and inhibition of CYP2C9 by Sulfaphenazole (a …
Pharmacokinetics of sulfaphenazole in sheep.
Odegaard SA. Odegaard SA. Acta Vet Scand. 1986;27(2):243-9. doi: 10.1186/BF03548168. Acta Vet Scand. 1986. PMID: 3799400 Free PMC article.
Proprietary formulations of sulfaphenazole were administered intravenously and orally to sheep. After intravenous injection the disposition of sulfaphenazole was described by an open two compartment model, and the elimination half-time was on average 5.58 h. ...
Proprietary formulations of sulfaphenazole were administered intravenously and orally to sheep. After intravenous injection the dispo …
Drug interactions with oral sulphonylurea hypoglycaemic drugs.
Hansen JM, Christensen LK. Hansen JM, et al. Drugs. 1977 Jan;13(1):24-34. doi: 10.2165/00003495-197713010-00003. Drugs. 1977. PMID: 401727 Review.
The effect of the oral sulphonylurea hypoglycaemic drugs may be influenced by a large number of other drugs. Some of these combinations (e.g. phenylbutazone, sulphaphenazole) may result in cases of severe hypoglycaemic collapse. ...
The effect of the oral sulphonylurea hypoglycaemic drugs may be influenced by a large number of other drugs. Some of these combinations (e.g …
Cytochrome P450 isozymes and antiepileptic drug interactions.
Levy RH. Levy RH. Epilepsia. 1995;36 Suppl 5:S8-13. doi: 10.1111/j.1528-1157.1995.tb06007.x. Epilepsia. 1995. PMID: 8806399 Review.
The principle of isoform specificity (drugs metabolized by the same isoform should exhibit interactions with the same inhibitors) was applied to the interactions of PHT with 17 inhibitors using two probes for CYP2C9, S-warfarin and tolbutamide. Eleven of 17 interactions (sulfa …
The principle of isoform specificity (drugs metabolized by the same isoform should exhibit interactions with the same inhibitors) was applie …
Characterization of kinetics of human cytochrome P450s involved in bioactivation of flucloxacillin: inhibition of CYP3A-catalysed hydroxylation by sulfaphenazole.
Dekker SJ, Dohmen F, Vermeulen NPE, Commandeur JNM. Dekker SJ, et al. Br J Pharmacol. 2019 Feb;176(3):466-477. doi: 10.1111/bph.14548. Epub 2018 Dec 26. Br J Pharmacol. 2019. PMID: 30447161 Free PMC article.
Michaelis-Menten enzyme kinetics were determined for pooled human liver microsomes, recombinant CYP3A4, CYP3A7 and CYP2C9. Surprisingly, sulfaphenazole appeared to be a potent inhibitor of 5'-hydroxylation of flucloxacillin by both recombinant CYP3A4 and CYP3A7. ...Additio …
Michaelis-Menten enzyme kinetics were determined for pooled human liver microsomes, recombinant CYP3A4, CYP3A7 and CYP2C9. Surprisingly, …
Trimethoprim/sulfonamide combinations in the horse: a review.
Van Duijkeren E, Vulto AG, Van Miert AS. Van Duijkeren E, et al. J Vet Pharmacol Ther. 1994 Feb;17(1):64-73. doi: 10.1111/j.1365-2885.1994.tb00524.x. J Vet Pharmacol Ther. 1994. PMID: 8196097 Review.
The binding of other sulfonamides to plasma proteins may range from 33% for sulfaphenazole (SPZ) to 93% for sulfadimethoxine (SDM). Sulfonamides are metabolized by acetylation of the para-amino (N4) group and by hydroxylation of the methyl group and the pyrimidine ring. .. …
The binding of other sulfonamides to plasma proteins may range from 33% for sulfaphenazole (SPZ) to 93% for sulfadimethoxine (SDM). S …
583 results