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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1991 3
1992 7
1993 7
1994 10
1995 20
1996 12
1997 20
1998 33
1999 21
2000 19
2001 30
2002 29
2003 23
2004 21
2005 20
2006 18
2007 16
2008 20
2009 22
2010 19
2011 22
2012 25
2013 24
2014 36
2015 33
2016 34
2017 32
2018 33
2019 21
2020 14
2021 29
2022 9
2023 17
2024 3

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645 results

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Page 1
Functional genomic landscape of acute myeloid leukaemia.
Tyner JW, Tognon CE, Bottomly D, Wilmot B, Kurtz SE, Savage SL, Long N, Schultz AR, Traer E, Abel M, Agarwal A, Blucher A, Borate U, Bryant J, Burke R, Carlos A, Carpenter R, Carroll J, Chang BH, Coblentz C, d'Almeida A, Cook R, Danilov A, Dao KT, Degnin M, Devine D, Dibb J, Edwards DK 5th, Eide CA, English I, Glover J, Henson R, Ho H, Jemal A, Johnson K, Johnson R, Junio B, Kaempf A, Leonard J, Lin C, Liu SQ, Lo P, Loriaux MM, Luty S, Macey T, MacManiman J, Martinez J, Mori M, Nelson D, Nichols C, Peters J, Ramsdill J, Rofelty A, Schuff R, Searles R, Segerdell E, Smith RL, Spurgeon SE, Sweeney T, Thapa A, Visser C, Wagner J, Watanabe-Smith K, Werth K, Wolf J, White L, Yates A, Zhang H, Cogle CR, Collins RH, Connolly DC, Deininger MW, Drusbosky L, Hourigan CS, Jordan CT, Kropf P, Lin TL, Martinez ME, Medeiros BC, Pallapati RR, Pollyea DA, Swords RT, Watts JM, Weir SJ, Wiest DL, Winters RM, McWeeney SK, Druker BJ. Tyner JW, et al. Nature. 2018 Oct;562(7728):526-531. doi: 10.1038/s41586-018-0623-z. Epub 2018 Oct 17. Nature. 2018. PMID: 30333627 Free PMC article.
Here we report initial findings from the Beat AML programme on a cohort of 672 tumour specimens collected from 562 patients. We assessed these specimens using whole-exome sequencing, RNA sequencing and analyses of ex vivo drug sensitivity. Our data reveal mutational events …
Here we report initial findings from the Beat AML programme on a cohort of 672 tumour specimens collected from 562 patients. We assessed the …
Partitioning of cancer therapeutics in nuclear condensates.
Klein IA, Boija A, Afeyan LK, Hawken SW, Fan M, Dall'Agnese A, Oksuz O, Henninger JE, Shrinivas K, Sabari BR, Sagi I, Clark VE, Platt JM, Kar M, McCall PM, Zamudio AV, Manteiga JC, Coffey EL, Li CH, Hannett NM, Guo YE, Decker TM, Lee TI, Zhang T, Weng JK, Taatjes DJ, Chakraborty A, Sharp PA, Chang YT, Hyman AA, Gray NS, Young RA. Klein IA, et al. Science. 2020 Jun 19;368(6497):1386-1392. doi: 10.1126/science.aaz4427. Science. 2020. PMID: 32554597 Free PMC article.
SRSF2 plays an unexpected role as reader of m5C on mRNA, linking epitranscriptomics to cancer.
Ma HL, Bizet M, Soares Da Costa C, Murisier F, de Bony EJ, Wang MK, Yoshimi A, Lin KT, Riching KM, Wang X, Beckman JI, Arya S, Droin N, Calonne E, Hassabi B, Zhang QY, Li A, Putmans P, Malbec L, Hubert C, Lan J, Mies F, Yang Y, Solary E, Daniels DL, Gupta YK, Deplus R, Abdel-Wahab O, Yang YG, Fuks F. Ma HL, et al. Mol Cell. 2023 Dec 7;83(23):4239-4254.e10. doi: 10.1016/j.molcel.2023.11.003. Mol Cell. 2023. PMID: 38065062
A common mRNA modification is 5-methylcytosine (m(5)C), whose role in gene-transcript processing and cancer remains unclear. Here, we identify serine/arginine-rich splicing factor 2 (SRSF2) as a reader of m(5)C and impaired SRSF2 m(5)C binding as a potential contrib …
A common mRNA modification is 5-methylcytosine (m(5)C), whose role in gene-transcript processing and cancer remains unclear. Here, we identi …
SRSF2 is required for mRNA splicing during spermatogenesis.
Lei WL, Du Z, Meng TG, Su R, Li YY, Liu W, Sun SM, Liu MY, Hou Y, Zhang CH, Gui Y, Schatten H, Han Z, Liu C, Sun F, Wang ZB, Qian WP, Sun QY. Lei WL, et al. BMC Biol. 2023 Oct 23;21(1):231. doi: 10.1186/s12915-023-01736-6. BMC Biol. 2023. PMID: 37867192 Free PMC article.
BACKGROUND: RNA splicing plays significant roles in fundamental biological activities. ...RESULTS: Here, we report that Serine/arginine-rich splicing factor 2 (SRSF2), also known as SC35, plays critical roles in alternative splicing and m …
BACKGROUND: RNA splicing plays significant roles in fundamental biological activities. ...RESULTS: Here, we report that Serine …
Splicing factor SRSF2-centric gene regulation.
Li K, Wang Z. Li K, et al. Int J Biol Sci. 2021 Apr 16;17(7):1708-1715. doi: 10.7150/ijbs.58888. eCollection 2021. Int J Biol Sci. 2021. PMID: 33994855 Free PMC article. Review.
Serine/arginine-rich splicing factor 2 (SRSF2) is a splicing factor that is widely expressed in a variety of mammalian cell types. ...
Serine/arginine-rich splicing factor 2 (SRSF2) is a splicing factor that is widely expressed in a variety of mam …
SON and SRRM2 are essential for nuclear speckle formation.
Ilik İA, Malszycki M, Lübke AK, Schade C, Meierhofer D, Aktaş T. Ilik İA, et al. Elife. 2020 Oct 23;9:e60579. doi: 10.7554/eLife.60579. Elife. 2020. PMID: 33095160 Free PMC article.
Unexpectedly, we found that this antibody was mischaracterized and the main target of SC35 mAb is SRRM2, a spliceosome-associated protein that sharply localizes to NS. ...One of the first nuclear territories to be identified were granular looking structures named Nuclear S …
Unexpectedly, we found that this antibody was mischaracterized and the main target of SC35 mAb is SRRM2, a spliceosome-associated pro …
Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction.
Condon KJ, Orozco JM, Adelmann CH, Spinelli JB, van der Helm PW, Roberts JM, Kunchok T, Sabatini DM. Condon KJ, et al. Proc Natl Acad Sci U S A. 2021 Jan 26;118(4):e2022120118. doi: 10.1073/pnas.2022120118. Proc Natl Acad Sci U S A. 2021. PMID: 33483422 Free PMC article.
In mammalian cells, nutrients and growth factors signal through an array of upstream proteins to regulate the mTORC1 growth control pathway. ...
In mammalian cells, nutrients and growth factors signal through an array of upstream proteins to regulate the mTORC1 growth control p …
Splicing factor mutations and cancer.
Yoshida K, Ogawa S. Yoshida K, et al. Wiley Interdiscip Rev RNA. 2014 Jul-Aug;5(4):445-59. doi: 10.1002/wrna.1222. Epub 2014 Feb 12. Wiley Interdiscip Rev RNA. 2014. PMID: 24523246 Free article. Review.
Splicing factor mutations have also been reported in solid cancers such as breast and pancreatic cancers, uveal melanomas, and lung adenocarcinomas. ...In this study, splicing factor mutations in various types of cancers, their functional/biological ef …
Splicing factor mutations have also been reported in solid cancers such as breast and pancreatic cancers, uveal melanomas, and …
Nuclear speckle integrity and function require TAO2 kinase.
Gao S, Esparza M, Dehghan I, Aksenova V, Zhang K, Batten K, Ferretti MB, Begg BE, Cagatay T, Shay JW, García-Sastre A, Goldsmith EJ, Chen ZJ, Dasso M, Lynch KW, Cobb MH, Fontoura BMA. Gao S, et al. Proc Natl Acad Sci U S A. 2022 Jun 21;119(25):e2206046119. doi: 10.1073/pnas.2206046119. Epub 2022 Jun 15. Proc Natl Acad Sci U S A. 2022. PMID: 35704758 Free PMC article.
Nuclear speckles are non-membrane-bound organelles known as storage sites for messenger RNA (mRNA) processing and splicing factors. More recently, nuclear speckles have also been implicated in splicing and export of a subset of mRNAs, including the inf …
Nuclear speckles are non-membrane-bound organelles known as storage sites for messenger RNA (mRNA) processing and splicing …
Liquid-liquid phase separation: Galectin-3 in nuclear speckles and ribonucleoprotein complexes.
Voss PG, Wang JL. Voss PG, et al. Exp Cell Res. 2023 Jun 1;427(1):113571. doi: 10.1016/j.yexcr.2023.113571. Epub 2023 Mar 31. Exp Cell Res. 2023. PMID: 37003559 Free PMC article. Review.
Nuclear speckles are subcellular structures originally characterized by punctate immunofluorescence staining of the monoclonal antibody SC35, which recognizes an epitope on SRRM2 (serine/arginine repetitive matrix protein 2) and Sfrs2, a member of the SR (serine/arginine-r …
Nuclear speckles are subcellular structures originally characterized by punctate immunofluorescence staining of the monoclonal antibody S …
645 results