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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1800 1
1842 1
1846 5
1853 1
1854 1
1857 8
1858 1
1864 1
1869 1
1873 1
1877 1
1886 1
1887 1
1888 6
1889 2
1890 1
1891 1
1899 1
1935 1
1945 1
1946 3
1947 8
1948 3
1949 2
1950 3
1951 7
1952 5
1953 6
1954 3
1955 7
1956 2
1957 13
1958 1
1959 3
1960 4
1961 3
1962 8
1963 8
1964 7
1965 3
1966 9
1967 11
1968 10
1969 11
1970 36
1971 43
1972 50
1973 60
1974 65
1975 60
1976 64
1977 88
1978 95
1979 99
1980 94
1981 61
1982 82
1983 110
1984 97
1985 117
1986 103
1987 96
1988 101
1989 94
1990 94
1991 90
1992 78
1993 76
1994 95
1995 116
1996 94
1997 101
1998 111
1999 89
2000 121
2001 94
2002 107
2003 101
2004 98
2005 102
2006 127
2007 114
2008 138
2009 144
2010 136
2011 158
2012 182
2013 193
2014 200
2015 208
2016 213
2017 186
2018 185
2019 172
2020 183
2021 173
2022 145
2023 147
2024 55

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5,887 results

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Page 1
High-dose saccharin supplementation does not induce gut microbiota changes or glucose intolerance in healthy humans and mice.
Serrano J, Smith KR, Crouch AL, Sharma V, Yi F, Vargova V, LaMoia TE, Dupont LM, Serna V, Tang F, Gomes-Dias L, Blakeslee JJ, Hatzakis E, Peterson SN, Anderson M, Pratley RE, Kyriazis GA. Serrano J, et al. Microbiome. 2021 Jan 12;9(1):11. doi: 10.1186/s40168-020-00976-w. Microbiome. 2021. PMID: 33431052 Free PMC article. Clinical Trial.
RESULTS: We conducted a double-blind, placebo-controlled, parallel arm study exploring the effects of pure saccharin compound on gut microbiota and glucose tolerance in healthy men and women. Participants were randomized to placebo, saccharin, lactisole (STR inhibit …
RESULTS: We conducted a double-blind, placebo-controlled, parallel arm study exploring the effects of pure saccharin compound on gut …
Saccharin-After the War.
[No authors listed] [No authors listed] JAMA. 2019 Mar 12;321(10):1010. doi: 10.1001/jama.2018.15242. JAMA. 2019. PMID: 30860551 No abstract available.
The saccharin controversy.
Kalkhoff RK, Levin ME. Kalkhoff RK, et al. Diabetes Care. 1978 Jul-Aug;1(4):211-22. doi: 10.2337/diacare.1.4.211. Diabetes Care. 1978. PMID: 400131 Review.
Saccharin and its salts are the most extensively consumed artificial sweeteners in the United States today. ...The April 1977 proposal by the Food and Drug Administration to restrict use of saccharin was based on these investigations. The intense public response aga …
Saccharin and its salts are the most extensively consumed artificial sweeteners in the United States today. ...The April 1977 proposa …
Saccharin.
Miller SA, Frattali VP. Miller SA, et al. Diabetes Care. 1989 Jan;12(1):74-80. doi: 10.2337/diacare.12.1.74. Diabetes Care. 1989. PMID: 2653753 Review.
Saccharin, a nonnutritive sweetener discovered in 1879, has been the subject of controversy concerning its effect on public health on several occasions during this century. ...
Saccharin, a nonnutritive sweetener discovered in 1879, has been the subject of controversy concerning its effect on public health on …
Saccharin's aversive taste in rats: evidence and implications.
Dess NK. Dess NK. Neurosci Biobehav Rev. 1993 Winter;17(4):359-72. doi: 10.1016/s0149-7634(05)80113-7. Neurosci Biobehav Rev. 1993. PMID: 8309647 Review.
This paper focuses on saccharin's lesser known, aversive properties. Evidence of saccharin's distinctive taste in rats is reviewed, followed by discussion of several modulating variables. Procedures that influence rats' responses to saccharin and their measur …
This paper focuses on saccharin's lesser known, aversive properties. Evidence of saccharin's distinctive taste in rats is revi …
Saccharin: a toxicological and historical perspective.
Arnold DL, Krewski D, Munro IC. Arnold DL, et al. Toxicology. 1983 Jul-Aug;27(3-4):179-256. doi: 10.1016/0300-483x(83)90021-5. Toxicology. 1983. PMID: 6353664 Review.
The dispute concerning the safety of saccharin for human consumption is almost as old as saccharin itself. ...A benefit-risk evaluation for saccharin showed few, if any documentable benefits from the use of saccharin and much genuine uncertainty concer …
The dispute concerning the safety of saccharin for human consumption is almost as old as saccharin itself. ...A benefit-risk e …
Saccharin--bitter aftertaste?
Hoover R. Hoover R. N Engl J Med. 1980 Mar 6;302(10):573-5. doi: 10.1056/NEJM198003063021009. N Engl J Med. 1980. PMID: 7351893 No abstract available.
Photoisomerization of saccharin.
Duarte L, Reva I, Cristiano ML, Fausto R. Duarte L, et al. J Org Chem. 2013 Apr 5;78(7):3271-5. doi: 10.1021/jo400191p. Epub 2013 Mar 18. J Org Chem. 2013. PMID: 23477671
Among several DFT methods used, the O3LYP/6-311++G(3df,3pd) level gave the best match with the experimental spectra. Irradiation of matrix-isolated saccharin, with a narrow-band source (290 nm), generates a so far unknown isomer that we call iso-saccharin. The struc …
Among several DFT methods used, the O3LYP/6-311++G(3df,3pd) level gave the best match with the experimental spectra. Irradiation of matrix-i …
The health risks of saccharin revisited.
Ellwein LB, Cohen SM. Ellwein LB, et al. Crit Rev Toxicol. 1990;20(5):311-26. doi: 10.3109/10408449009089867. Crit Rev Toxicol. 1990. PMID: 2202324 Review.
It also appears that the effect of saccharin is modified by the salt form in which it is administered, despite equivalent concentrations of saccharin in the urine. The chemical form of saccharin in the urine is unaffected, and there is no evidence for a speci …
It also appears that the effect of saccharin is modified by the salt form in which it is administered, despite equivalent concentrati …
Two-generation saccharin bioassays.
Arnold DL. Arnold DL. Environ Health Perspect. 1983 Apr;50:27-36. doi: 10.1289/ehp.835027. Environ Health Perspect. 1983. PMID: 6347682 Free PMC article.
The consumption of saccharin, particularly in North America, began to escalate when the U.S. ...The mechanism by which saccharin elicited the bladder tumors using the two-generation experiment has not been ascertained....
The consumption of saccharin, particularly in North America, began to escalate when the U.S. ...The mechanism by which saccharin …
5,887 results