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A phospholipase A2 inhibitor (Ro 31-4493) prevents protein loss associated with the calcium paradox in isolated guinea pig hearts without effect on contracture, calcium overload, or the currents through L-type calcium channels.
Suleiman MS, Minezaki KK, Ban K, Chapman RA. Suleiman MS, et al. Cardiovasc Res. 1994 May;28(5):650-5. doi: 10.1093/cvr/28.5.650. Cardiovasc Res. 1994. PMID: 8025908
This possibility was examined in this work. EXPERIMENTAL DESIGN: The effect of Ro 31-4493, a phospholipase A2 inhibitor, upon protein loss, hypercontracture, and ultrastructural changes in Langendorff perfused guinea pig hearts during the calcium paradox was …
This possibility was examined in this work. EXPERIMENTAL DESIGN: The effect of Ro 31-4493, a phospholipase A2 inhibitor …
Phospholipase A2 activation and subsequent exocytosis in the Ca2+/ionophore-induced acrosome reaction of ram spermatozoa.
Roldan ER, Fragio C. Roldan ER, et al. J Biol Chem. 1993 Jul 5;268(19):13962-70. J Biol Chem. 1993. PMID: 8314762 Free article.
Moreover, it was significantly correlated with exocytosis when spermatozoa were stimulated with Ca2+ and A23187 or ionomycin for different periods of time or with different ionophore concentrations. Treatment with Ro 31-4493, a compound that has been found to …
Moreover, it was significantly correlated with exocytosis when spermatozoa were stimulated with Ca2+ and A23187 or ionomycin for different p …
Diacylglycerol stimulates the Ca2(+)-dependent phospholipase A2 of ram spermatozoa.
Roldan ER, Mollinedo F. Roldan ER, et al. Biochem Biophys Res Commun. 1991 Apr 15;176(1):294-300. doi: 10.1016/0006-291x(91)90923-u. Biochem Biophys Res Commun. 1991. PMID: 2018523
Ram sperm PLA2 activity was Ca2(+)-dependent and was inhibited by dexamethasone, chloracysine and compounds Ro 31-4493 and Ro 31-4639; mepacrine, however, did not inhibit PLA2 activity. ...
Ram sperm PLA2 activity was Ca2(+)-dependent and was inhibited by dexamethasone, chloracysine and compounds Ro 31-4493 …
Effect of long-chain alkylamines on arachidonate metabolism in macrophages.
Dieter P, Fitzke E. Dieter P, et al. Biol Chem Hoppe Seyler. 1991 Oct;372(10):943-6. doi: 10.1515/bchm3.1991.372.2.943. Biol Chem Hoppe Seyler. 1991. PMID: 1663365
The two long-chain alkylamines RO 31-4493 and RO 31-4639 inhibit in a concentration-dependent manner the zymosan-induced release of arachidonic acid, the conversion of arachidonic acid into thromboxane, prostaglandin E2 and D2 and the uptake and incorporation …
The two long-chain alkylamines RO 31-4493 and RO 31-4639 inhibit in a concentration-dependent manner the zymosan-induce …