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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1984 1
1985 1
1986 1
1987 6
1988 11
1989 13
1990 12
1991 21
1992 19
1993 21
1994 32
1995 24
1996 33
1997 49
1998 48
1999 46
2000 68
2001 72
2002 88
2003 143
2004 180
2005 195
2006 193
2007 230
2008 260
2009 273
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2024 174

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6,812 results

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Page 1
Insights into ubiquitin chain architecture using Ub-clipping.
Swatek KN, Usher JL, Kueck AF, Gladkova C, Mevissen TET, Pruneda JN, Skern T, Komander D. Swatek KN, et al. Nature. 2019 Aug;572(7770):533-537. doi: 10.1038/s41586-019-1482-y. Epub 2019 Aug 15. Nature. 2019. PMID: 31413367 Free PMC article.
Advances in mass spectrometry have enabled the mapping of individual ubiquitin modifications that generate the ubiquitin code; however, the architecture of polyubiquitin signals has remained largely inaccessible. Here we introduce Ub-clipping as a methodology by which to u …
Advances in mass spectrometry have enabled the mapping of individual ubiquitin modifications that generate the ubiquitin code; however, the …
TRIM15 and CYLD regulate ERK activation via lysine-63-linked polyubiquitination.
Zhu G, Herlyn M, Yang X. Zhu G, et al. Nat Cell Biol. 2021 Sep;23(9):978-991. doi: 10.1038/s41556-021-00732-8. Epub 2021 Sep 8. Nat Cell Biol. 2021. PMID: 34497368 Free PMC article.
Here, we show that ERK1/2 are also modified by lysine-63 (K63)-linked polyubiquitin chains. We identify the tripartite motif-containing protein TRIM15 as a ubiquitin ligase and the tumour suppressor CYLD as a deubiquitinase of ERK1/2. TRIM15 and CYLD regulate ERK ubiquitin …
Here, we show that ERK1/2 are also modified by lysine-63 (K63)-linked polyubiquitin chains. We identify the tripartite motif-containi …
PUB25 and PUB26 dynamically modulate ICE1 stability via differential ubiquitination during cold stress in Arabidopsis.
Wang X, Zhang X, Song CP, Gong Z, Yang S, Ding Y. Wang X, et al. Plant Cell. 2023 Sep 1;35(9):3585-3603. doi: 10.1093/plcell/koad159. Plant Cell. 2023. PMID: 37279565
Ubiquitination modulates protein turnover or activity depending on the number and location of attached ubiquitin (Ub) moieties. Proteins marked by a lysine 48 (K48)-linked polyubiquitin chain are usually targeted to the 26S proteasome for degradation; however, other pol …
Ubiquitination modulates protein turnover or activity depending on the number and location of attached ubiquitin (Ub) moieties. Proteins mar …
Polyubiquitin chain-induced p62 phase separation drives autophagic cargo segregation.
Sun D, Wu R, Zheng J, Li P, Yu L. Sun D, et al. Cell Res. 2018 Apr;28(4):405-415. doi: 10.1038/s41422-018-0017-7. Epub 2018 Mar 5. Cell Res. 2018. PMID: 29507397 Free PMC article.
Mixing recombinant p62 with cytosol from p62(-/-) cells also results in p62 phase separation in a polyubiquitination-dependent manner. Mechanistically, p62 phase separation is dependent on p62 polymerization, the interaction between p62 and ubiquitin, and the valence of th …
Mixing recombinant p62 with cytosol from p62(-/-) cells also results in p62 phase separation in a polyubiquitination-dependent manner …
Ubiquitination in the ERAD Process.
Lopata A, Kniss A, Löhr F, Rogov VV, Dötsch V. Lopata A, et al. Int J Mol Sci. 2020 Jul 28;21(15):5369. doi: 10.3390/ijms21155369. Int J Mol Sci. 2020. PMID: 32731622 Free PMC article. Review.
MAVS-loaded unanchored Lys63-linked polyubiquitin chains activate the RIG-I-MAVS signaling cascade.
Liu F, Zhuang W, Song B, Yang Y, Liu J, Zheng Y, Liu B, Zheng J, Zhao W, Gao C. Liu F, et al. Cell Mol Immunol. 2023 Oct;20(10):1186-1202. doi: 10.1038/s41423-023-01065-2. Epub 2023 Aug 15. Cell Mol Immunol. 2023. PMID: 37582970
Here, we found that the K63-linked polyubiquitin chains loaded on MAVS can be directly recognized by RIG-I to initiate RIG-I-mediated MAVS aggregation with the prerequisite of the CARD(RIG-I)-CARD(MAVS) interaction. Interestingly, many K63-linked polyubiquitin chain …
Here, we found that the K63-linked polyubiquitin chains loaded on MAVS can be directly recognized by RIG-I to initiate RIG-I-mediated …
UBE4A catalyzes NRF1 ubiquitination and facilitates DDI2-mediated NRF1 cleavage.
Hu X, Zou R, Zhang Z, Ji J, Li J, Huo XY, Liu D, Ge MX, Cui MK, Wu MZ, Li ZP, Wang Q, Zhang X, Zhang ZR. Hu X, et al. Biochim Biophys Acta Gene Regul Mech. 2023 Jun;1866(2):194937. doi: 10.1016/j.bbagrm.2023.194937. Epub 2023 Apr 19. Biochim Biophys Acta Gene Regul Mech. 2023. PMID: 37084817
DDI2 cleaves and activates NRF1 only when NRF1 is highly polyubiquitinated. It remains unclear how retrotranslocated NRF1 is primed with large amount of ubiquitin and/or very long polyubiquitin chain for subsequent processing. ...Depletion of UBE4A reduces the amoun …
DDI2 cleaves and activates NRF1 only when NRF1 is highly polyubiquitinated. It remains unclear how retrotranslocated NRF1 is primed w …
Polyubiquitin ligand-induced phase transitions are optimized by spacing between ubiquitin units.
Galagedera SKK, Dao TP, Enos SE, Chaudhuri A, Schmit JD, Castañeda CA. Galagedera SKK, et al. Proc Natl Acad Sci U S A. 2023 Oct 17;120(42):e2306638120. doi: 10.1073/pnas.2306638120. Epub 2023 Oct 12. Proc Natl Acad Sci U S A. 2023. PMID: 37824531 Free PMC article.
One such modification is ubiquitination, the covalent addition of ubiquitin (Ub) or polyubiquitin chains to target macromolecules. Specific interactions between polyubiquitin chains and partner proteins, including hHR23B, NEMO, and UBQLN2, regulate condensate assemb …
One such modification is ubiquitination, the covalent addition of ubiquitin (Ub) or polyubiquitin chains to target macromolecules. Sp …
Proteasomes.
Dahlmann B. Dahlmann B. Essays Biochem. 2005;41:31-48. doi: 10.1042/EB0410031. Essays Biochem. 2005. PMID: 16250896 Review.
These regulatory complexes are able to bind proteins marked as proteasome substrates by prior conjugation with polyubiquitin chains, and initiate their unfolding and translocation into the proteolytic chamber of the 20 S proteasome, where they are broken down into peptides …
These regulatory complexes are able to bind proteins marked as proteasome substrates by prior conjugation with polyubiquitin chains, …
Ubiquitin-binding domains.
Hurley JH, Lee S, Prag G. Hurley JH, et al. Biochem J. 2006 Nov 1;399(3):361-72. doi: 10.1042/BJ20061138. Biochem J. 2006. PMID: 17034365 Free PMC article. Review.
The structures of many of the complexes with mono-ubiquitin have been determined, revealing interactions with multiple surfaces on ubiquitin. Inroads into understanding polyubiquitin specificity have been made for two UBA domains, whose structures have been characterized i …
The structures of many of the complexes with mono-ubiquitin have been determined, revealing interactions with multiple surfaces on ubiquitin …
6,812 results