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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1958 3
1959 8
1960 15
1961 18
1962 22
1963 46
1964 48
1965 31
1966 27
1967 29
1968 94
1969 78
1970 53
1971 74
1972 91
1973 83
1974 81
1975 78
1976 79
1977 70
1978 79
1979 58
1980 38
1981 16
1982 22
1983 20
1984 23
1985 14
1986 15
1987 6
1988 13
1989 5
1990 9
1991 13
1992 14
1993 8
1994 8
1995 6
1996 9
1997 8
1998 7
1999 8
2000 4
2001 2
2002 11
2003 10
2004 10
2005 12
2006 13
2007 12
2008 12
2009 11
2010 19
2011 22
2012 19
2013 21
2014 31
2015 36
2016 32
2017 36
2018 40
2019 29
2020 33
2021 39
2022 18
2023 26
2024 6

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1,880 results

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Page 1
A review of phenformin, metformin, and imeglimin.
Yendapally R, Sikazwe D, Kim SS, Ramsinghani S, Fraser-Spears R, Witte AP, La-Viola B. Yendapally R, et al. Drug Dev Res. 2020 Jun;81(4):390-401. doi: 10.1002/ddr.21636. Epub 2020 Jan 9. Drug Dev Res. 2020. PMID: 31916629 Review.
Diabetes mellitus is a serious metabolic disorder affecting millions of people worldwide. Phenformin and metformin are biguanide antidiabetic agents that are conveniently synthesized in a single-step chemical reaction. Phenformin was once used to lower blood glucose …
Diabetes mellitus is a serious metabolic disorder affecting millions of people worldwide. Phenformin and metformin are biguanide anti …
Phenformin as an Anticancer Agent: Challenges and Prospects.
García Rubiño ME, Carrillo E, Ruiz Alcalá G, Domínguez-Martín A, A Marchal J, Boulaiz H. García Rubiño ME, et al. Int J Mol Sci. 2019 Jul 5;20(13):3316. doi: 10.3390/ijms20133316. Int J Mol Sci. 2019. PMID: 31284513 Free PMC article. Review.
Moreover, the addition of phenformin eliminates resistance to antiangiogenic tyrosine kinase inhibitors (TKI), which prevent the uncontrolled metabolism of glucose in tumor cells. In this review, we evidence the great potential of phenformin as an anticancer agent. …
Moreover, the addition of phenformin eliminates resistance to antiangiogenic tyrosine kinase inhibitors (TKI), which prevent the unco …
Phenformin: AMP(K)ed for Potential Repurposing.
Jung J, Bollag WB. Jung J, et al. J Invest Dermatol. 2021 Jan;141(1):11-14. doi: 10.1016/j.jid.2020.06.008. J Invest Dermatol. 2021. PMID: 33342506 Free article.
The results in the article by Zhou et al. (2020) demonstrate that the antidiabetic drug phenformin inhibits skin tumor growth and promotes keratinocyte differentiation, and an underlying mechanism is also defined. In this commentary, additional potential mechanisms through …
The results in the article by Zhou et al. (2020) demonstrate that the antidiabetic drug phenformin inhibits skin tumor growth and pro …
Phenformin increases early hematopoietic progenitors in the Jak2(V617F) murine model.
Alves-Silva AB, Fenerich BA, Fonseca NP, Fernandes JC, Coelho-Silva JL, Pereira-Martins DA, Bianco TM, Scheucher PS, Rego EM, Chahud F, Machado-Neto JA, Figueiredo-Pontes LL, Traina F. Alves-Silva AB, et al. Invest New Drugs. 2022 Jun;40(3):576-585. doi: 10.1007/s10637-022-01212-y. Epub 2022 Jan 11. Invest New Drugs. 2022. PMID: 35015172
RESULTS: In vitro phenformin treatment reduced cell viability and increased apoptosis in SET2 JAK2(V67F) cells. ...Additional studies are necessary to further understand the effects of phenformin on early hematopoietic progenitors....
RESULTS: In vitro phenformin treatment reduced cell viability and increased apoptosis in SET2 JAK2(V67F) cells. ...Additional studies …
Phenformin Down-Regulates c-Myc Expression to Suppress the Expression of Pro-Inflammatory Cytokines in Keratinocytes.
Liu G, Li D, Zhang L, Xu Q, Zhuang D, Liu P, Hu L, Deng H, Sun J, Wang S, Zheng B, Guo J, Wu X. Liu G, et al. Cells. 2022 Aug 5;11(15):2429. doi: 10.3390/cells11152429. Cells. 2022. PMID: 35954273 Free PMC article.
We demonstrated that the overexpression of c-Myc can induce pro-inflammatory cytokine expression and counteract the suppressive effect of phenformin on cytokine expression in keratinocytes. In contrast, the down-regulation of c-Myc produces effects similar to phenformin …
We demonstrated that the overexpression of c-Myc can induce pro-inflammatory cytokine expression and counteract the suppressive effect of …
Phenformin Inhibits Hedgehog-Dependent Tumor Growth through a Complex I-Independent Redox/Corepressor Module.
Di Magno L, Manni S, Di Pastena F, Coni S, Macone A, Cairoli S, Sambucci M, Infante P, Moretti M, Petroni M, Nicoletti C, Capalbo C, De Smaele E, Di Marcotullio L, Giannini G, Battistini L, Goffredo BM, Iorio E, Agostinelli E, Maroder M, Canettieri G. Di Magno L, et al. Cell Rep. 2020 Feb 11;30(6):1735-1752.e7. doi: 10.1016/j.celrep.2020.01.024. Cell Rep. 2020. PMID: 32049007 Free article.
The antidiabetic drug phenformin displays potent anticancer activity in different tumors, but its mechanism of action remains elusive. ...Phenformin inhibits mitochondrial glycerophosphate dehydrogenase (mGPD), a component of the glycerophosphate shuttle, and causes …
The antidiabetic drug phenformin displays potent anticancer activity in different tumors, but its mechanism of action remains elusive …
[Phenformin].
[No authors listed] [No authors listed] Journ Annu Diabetol Hotel Dieu. 1967;7:427-30. Journ Annu Diabetol Hotel Dieu. 1967. PMID: 4862374 Review. French. No abstract available.
Phenformin and lactic acidosis: a case report and review.
Kwong SC, Brubacher J. Kwong SC, et al. J Emerg Med. 1998 Nov-Dec;16(6):881-6. doi: 10.1016/s0736-4679(98)00103-6. J Emerg Med. 1998. PMID: 9848705 Review.
Phenformin was removed from the U.S. market 20 years ago because of a high incidence of lactic acidosis. ...We also review its pathophysiology, presentation, and treatment. A review of the actions of phenformin illustrates the mechanism of pathology that may also oc …
Phenformin was removed from the U.S. market 20 years ago because of a high incidence of lactic acidosis. ...We also review its pathop …
Phenformin-induced lactic acidosis: a forgotten adverse drug reaction.
McGuinness ME, Talbert RL. McGuinness ME, et al. Ann Pharmacother. 1993 Oct;27(10):1183-7. doi: 10.1177/106002809302701004. Ann Pharmacother. 1993. PMID: 8251683 Review.
OBJECTIVE: To document a case of severe metabolic and lactic acidosis secondary to phenformin. This adverse effect has almost been forgotten as 15 years have passed since its withdrawal from the US market. ...Metformin, another biguanide under investigation for the treatme …
OBJECTIVE: To document a case of severe metabolic and lactic acidosis secondary to phenformin. This adverse effect has almost been fo …
Phenformin acidosis.
GOTTLIEB A, DUBERSTEIN J, GELLER A. GOTTLIEB A, et al. N Engl J Med. 1962 Oct 18;267:806-9. doi: 10.1056/NEJM196210182671604. N Engl J Med. 1962. PMID: 13949484 No abstract available.
1,880 results