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Omega 3 (peripheral type benzodiazepine binding) site distribution in the rat immune system: an autoradiographic study with the photoaffinity ligand [3H]PK 14105.
Benavides J, Dubois A, Dennis T, Hamel E, Scatton B. Benavides J, et al. J Pharmacol Exp Ther. 1989 Apr;249(1):333-9. J Pharmacol Exp Ther. 1989. PMID: 2540320
The anatomical distribution of omega 3 (peripheral type benzodiazepine binding) sites in the immune system organs of the rat has been studied autoradiographically at both macroscopic and microscopic levels of resolution using either reversible or irreversible (UV irradiation) lab …
The anatomical distribution of omega 3 (peripheral type benzodiazepine binding) sites in the immune system organs of the rat has been studie …
The radiosynthesis of [18F]PK 14105 as an alternative radioligand for peripheral type benzodiazepine binding sites.
Pascali C, Luthra SK, Pike VW, Price GW, Ahier RG, Hume SP, Myers R, Manjil L, Cremer JE. Pascali C, et al. Int J Rad Appl Instrum A. 1990;41(5):477-82. doi: 10.1016/0883-2889(90)90008-5. Int J Rad Appl Instrum A. 1990. PMID: 2166014
The radiosynthesis requires 210 min. giving a radiochemical yield of 10-20%, decay-corrected to EOB. [18F]PK 14105 was found to bind avidly to sites associated with kainic acid-induced unilateral lesions of rat striata. Such binding was blocked by pre-dosing the rat …
The radiosynthesis requires 210 min. giving a radiochemical yield of 10-20%, decay-corrected to EOB. [18F]PK 14105 was found t …
Cellular distribution of omega 3 (peripheral type benzodiazepine) binding sites in the normal and ischaemic rat brain: an autoradiographic study with the photoaffinity ligand [3H]PK 14105.
Benavides J, Dubois A, Gotti B, Bourdiol F, Scatton B. Benavides J, et al. Neurosci Lett. 1990 Jun 22;114(1):32-8. doi: 10.1016/0304-3940(90)90424-8. Neurosci Lett. 1990. PMID: 2166260
The microscopic distribution of omega 3 (peripheral type benzodiazepine) binding sites in sections from normal and ischaemic rat brain has been determined by emulsion autoradiography with the photoaffinity ligand [3H]PK 14105. In the normal rat brain, high densities …
The microscopic distribution of omega 3 (peripheral type benzodiazepine) binding sites in sections from normal and ischaemic rat brain has b …
Molecular mechanisms of peripheral benzodiazepine receptors.
Snyder SH, McEnery MW, Verma A. Snyder SH, et al. Neurochem Res. 1990 Feb;15(2):119-23. doi: 10.1007/BF00972201. Neurochem Res. 1990. PMID: 2159119 Review.
This complex is functionally intact as determined by its ability to reversibly bind PK-11195, Ro5-4864, and PK-14105 with high affinity and specificity....
This complex is functionally intact as determined by its ability to reversibly bind PK-11195, Ro5-4864, and PK-14105 with high …
Photoaffinity labeling of peripheral-type benzodiazepine-binding sites.
Doble A, Ferris O, Burgevin MC, Menager J, Uzan A, Dubroeucq MC, Renault C, Gueremy C, Le Fur G. Doble A, et al. Mol Pharmacol. 1987 Jan;31(1):42-9. Mol Pharmacol. 1987. PMID: 3027525
The use of a novel photoaffinity label for the peripheral-type benzodiazepine-binding site is described. This compound, PK 14105, has high affinity (4 nM) and selectivity for cardiac benzodiazepine-binding sites. Under ultraviolet light, PK 14105 coupl …
The use of a novel photoaffinity label for the peripheral-type benzodiazepine-binding site is described. This compound, PK 14105 …
Cofractionation of the 17-kD PK 14105 binding site protein with solubilized peripheral-type benzodiazepine binding sites.
Mukhin AG, Zhong PY, Krueger KE. Mukhin AG, et al. Biochem Pharmacol. 1990 Sep 1;40(5):983-9. doi: 10.1016/0006-2952(90)90483-2. Biochem Pharmacol. 1990. PMID: 2167683
To examine the relationship between PKBS, a 17-kD protein covalently photolabeled by [3H]PK 14105, and its association with peripheral-type benzodiazepine binding sites, rat adrenal mitochondrial fractions were photolabeled with [3H]PK 14105, solubiliz …
To examine the relationship between PKBS, a 17-kD protein covalently photolabeled by [3H]PK 14105, and its association with pe …
Photoaffinity labeling of peripheral-type benzodiazepine receptors in rat kidney mitochondria with [3H]PK 14105.
Skowroński R, Fanestil DD, Beaumont K. Skowroński R, et al. Eur J Pharmacol. 1988 Mar 29;148(2):187-93. doi: 10.1016/0014-2999(88)90563-8. Eur J Pharmacol. 1988. PMID: 2837399
The peripheral-type benzodiazepine receptor in rat kidney has been identified by photoaffinity labeling. PK 14105, a derivative of the selective peripheral-type ligand PK 11195, was used to covalently label peripheral-type benzodiazepine receptors. In the absence of …
The peripheral-type benzodiazepine receptor in rat kidney has been identified by photoaffinity labeling. PK 14105, a derivativ …
Partial purification and pharmacology of peripheral-type benzodiazepine receptors.
Doble A, Burgevin MC, Ménager J, Ferris O, Bégassat F, Renault C, Dubroeucq MC, Guérémy C, Uzan A, Le Fur G. Doble A, et al. J Recept Res. 1987;7(1-4):55-70. doi: 10.3109/10799898709054979. J Recept Res. 1987. PMID: 3040984
The apparent molecular weight of the solubilized PBS, determined by gel filtration is 215 KDa. The photoaffinity ligand (PK 14105) is a nitrophenyl derivative of PK 11195, which attaches covalently and specifically to all the PBS when cardiac membranes are irradiate …
The apparent molecular weight of the solubilized PBS, determined by gel filtration is 215 KDa. The photoaffinity ligand (PK 14105 …
Solubilization and characterization of the liver peripheral-type benzodiazepine receptor.
Parola AL, Putnam CW, Russell DH, Laird HE 2nd. Parola AL, et al. J Pharmacol Exp Ther. 1989 Sep;250(3):1149-55. J Pharmacol Exp Ther. 1989. PMID: 2550618
Thus, the soluble receptor had ligand binding characteristics similar to those of the membrane PBZR. [3H]PK-14105 was used to photoaffinity label the PBZR in a rat liver homogenate. Labeling was specific for the PBZR and the molecular weight of the digitonin-solubil …
Thus, the soluble receptor had ligand binding characteristics similar to those of the membrane PBZR. [3H]PK-14105 was used to …
Photochemical derivatization of agarose: synthesis of an affinity agarose using a photoaffinity ligand specific for the peripheral-type benzodiazepine receptor.
Parola AL, MacKenzie NE, Laird HE 2nd. Parola AL, et al. Anal Biochem. 1990 Aug 15;189(1):107-14. doi: 10.1016/0003-2697(90)90054-d. Anal Biochem. 1990. PMID: 2177588
PK 14105, a photoaffinity ligand specific for the peripheral-type benzodiazepine receptor (PBZR), was photochemically coupled to omega-aminobutyl agarose (ABAg) to yield PK 14105 agarose (PKAg). 19F and 1H NMR spectroscopy were consistent with the prop …
PK 14105, a photoaffinity ligand specific for the peripheral-type benzodiazepine receptor (PBZR), was photochemically coupled …
36 results