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Year Number of Results
1975 1
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1978 7
1979 2
1980 4
1981 2
1982 2
1983 3
1984 1
1985 1
1986 1
1988 2
1990 1
1991 1
1992 1
1993 2
1995 3
1996 1
1999 1
2000 2
2002 1
2004 2
2006 1
2007 2
2009 5
2010 4
2011 1
2012 1
2013 3
2014 9
2015 5
2016 5
2017 4
2018 10
2019 5
2020 3
2021 6
2022 2
2023 4
2024 0

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106 results

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Page 1
Gastrointestinal Parasites in Shelter Dogs: Occurrence, Pathology, Treatment and Risk to Shelter Workers.
Raza A, Rand J, Qamar AG, Jabbar A, Kopp S. Raza A, et al. Animals (Basel). 2018 Jul 2;8(7):108. doi: 10.3390/ani8070108. Animals (Basel). 2018. PMID: 30004469 Free PMC article. Review.
A range of cost-effective drugs is available for prevention and control of helminths in shelters, notably fenbendazole, pyrantel, oxantel, and praziquantel. Parasiticide options for protozoan parasites are often cost-prohibitive or limited by a lack of veterinary registrat …
A range of cost-effective drugs is available for prevention and control of helminths in shelters, notably fenbendazole, pyrantel, oxantel …
Preclinical and Clinical Characteristics of the Trichuricidal Drug Oxantel Pamoate and Clinical Development Plans: A Review.
Palmeirim MS, Specht S, Scandale I, Gander-Meisterernst I, Chabicovsky M, Keiser J. Palmeirim MS, et al. Drugs. 2021 Jun;81(8):907-921. doi: 10.1007/s40265-021-01505-1. Epub 2021 Apr 30. Drugs. 2021. PMID: 33929716 Free PMC article. Review.
This review summarizes the current knowledge on oxantel pamoate and its use against T. trichiura infections in humans. ...We highlight existing data to support the use of oxantel pamoate against T. trichiura infections....
This review summarizes the current knowledge on oxantel pamoate and its use against T. trichiura infections in humans. ...We highligh …
Efficacy and tolerability of triple drug therapy with albendazole, pyrantel pamoate, and oxantel pamoate compared with albendazole plus oxantel pamoate, pyrantel pamoate plus oxantel pamoate, and mebendazole plus pyrantel pamoate and oxantel pamoate against hookworm infections in school-aged children in Laos: a randomised, single-blind trial.
Moser W, Sayasone S, Xayavong S, Bounheuang B, Puchkov M, Huwyler J, Hattendorf J, Keiser J. Moser W, et al. Lancet Infect Dis. 2018 Jul;18(7):729-737. doi: 10.1016/S1473-3099(18)30220-2. Epub 2018 Apr 16. Lancet Infect Dis. 2018. PMID: 29673735 Clinical Trial.
Hookworm-positive children were randomly assigned (2:2:1:1) by a computer stratified list (block sizes of six and 12) to TDT with albendazole (400 mg), pyrantel pamoate (20 mg/kg), and oxantel pamoate (20 mg/kg); albendazole plus oxantel pamoate; pyrantel pamoate pl …
Hookworm-positive children were randomly assigned (2:2:1:1) by a computer stratified list (block sizes of six and 12) to TDT with albendazol …
Oxantel pamoate-albendazole for Trichuris trichiura infection.
Speich B, Ame SM, Ali SM, Alles R, Huwyler J, Hattendorf J, Utzinger J, Albonico M, Keiser J. Speich B, et al. N Engl J Med. 2014 Feb 13;370(7):610-20. doi: 10.1056/NEJMoa1301956. N Engl J Med. 2014. PMID: 24521107 Free article. Clinical Trial.
METHODS: In this double-blind trial conducted on Pemba Island, Tanzania, we randomly assigned children, 6 to 14 years of age, to receive one of four treatments: oxantel pamoate at a dose of 20 mg per kilogram of body weight, plus 400 mg of albendazole, administered on cons …
METHODS: In this double-blind trial conducted on Pemba Island, Tanzania, we randomly assigned children, 6 to 14 years of age, to receive one …
Functional Characterization of the Oxantel-Sensitive Acetylcholine Receptor from Trichuris muris.
Hansen TVA, Grencis RK, Issouf M, Neveu C, Charvet CL. Hansen TVA, et al. Pharmaceuticals (Basel). 2021 Jul 20;14(7):698. doi: 10.3390/ph14070698. Pharmaceuticals (Basel). 2021. PMID: 34358124 Free PMC article.
Control of human trichuriasis is a particular challenge, as most anthelmintics have a limited single-dose efficacy, with the striking exception of the narrow-spectrum anthelmintic, oxantel. We recently identified a novel ACR-16-like subunit from the pig whipworm, T. suis w …
Control of human trichuriasis is a particular challenge, as most anthelmintics have a limited single-dose efficacy, with the striking except …
In Vitro and In Vivo Drug-Drug Interaction Study of the Effects of Ivermectin and Oxantel Pamoate on Tribendimidine.
Neodo A, Schulz JD, Huwyler J, Keiser J. Neodo A, et al. Antimicrob Agents Chemother. 2018 Dec 21;63(1):e00762-18. doi: 10.1128/AAC.00762-18. Print 2019 Jan. Antimicrob Agents Chemother. 2018. PMID: 30323047 Free PMC article.
The combination of tribendimidine with either ivermectin or oxantel pamoate targets a broad range of STHs and thus represents a promising treatment alternative. ...Oxantel pamoate is only poorly absorbed and was therefore excluded from pharmacokinetic analysis. ...
The combination of tribendimidine with either ivermectin or oxantel pamoate targets a broad range of STHs and thus represents a promi …
The narrow-spectrum anthelmintic oxantel is a potent agonist of a novel acetylcholine receptor subtype in whipworms.
Hansen TVA, Cirera S, Neveu C, Courtot E, Charvet CL, Calloe K, Klaerke DA, Martin RJ. Hansen TVA, et al. PLoS Pathog. 2021 Feb 5;17(2):e1008982. doi: 10.1371/journal.ppat.1008982. eCollection 2021 Feb. PLoS Pathog. 2021. PMID: 33544769 Free PMC article.
However, in contrast to a wide range of parasitic nematode species, the narrow-spectrum anthelmintic oxantel has a high efficacy on Trichuris spp. Despite this knowledge, the molecular target(s) of oxantel within Trichuris is still unknown. ...We observed that the e …
However, in contrast to a wide range of parasitic nematode species, the narrow-spectrum anthelmintic oxantel has a high efficacy on T …
Efficacy and safety of oxantel pamoate in school-aged children infected with Trichuris trichiura on Pemba Island, Tanzania: a parallel, randomised, controlled, dose-ranging study.
Moser W, Ali SM, Ame SM, Speich B, Puchkov M, Huwyler J, Albonico M, Hattendorf J, Keiser J. Moser W, et al. Lancet Infect Dis. 2016 Jan;16(1):53-60. doi: 10.1016/S1473-3099(15)00271-6. Epub 2015 Sep 18. Lancet Infect Dis. 2016. PMID: 26388169 Clinical Trial.
INTERPRETATION: Our dose-finding study revealed an excellent tolerability profile of oxantel pamoate in children infected with T trichiura. An optimum therapeutic dose range of 15-30 mg/kg oxantel pamoate was defined. ...Future research should include studies with …
INTERPRETATION: Our dose-finding study revealed an excellent tolerability profile of oxantel pamoate in children infected with T tric …
The pipeline for drugs for control and elimination of neglected tropical diseases: 2. Oral anti-infective drugs and drug combinations for off-label use.
Pfarr KM, Krome AK, Al-Obaidi I, Batchelor H, Vaillant M, Hoerauf A, Opoku NO, Kuesel AC. Pfarr KM, et al. Parasit Vectors. 2023 Oct 31;16(1):394. doi: 10.1186/s13071-023-05909-8. Parasit Vectors. 2023. PMID: 37907954 Free PMC article. Review.
Oral drugs evaluated include sparfloxacin and acedapsone for leprosy; rifampicin, rifapentin and moxifloxacin for onchocerciasis; imatinib and levamisole for loiasis; itraconazole, fluconazole, ketoconazole, posaconazole, ravuconazole and disulfiram for Chagas disease, doxycyclin …
Oral drugs evaluated include sparfloxacin and acedapsone for leprosy; rifampicin, rifapentin and moxifloxacin for onchocerciasis; imatinib a …
Activity of oxantel pamoate monotherapy and combination chemotherapy against Trichuris muris and hookworms: revival of an old drug.
Keiser J, Tritten L, Silbereisen A, Speich B, Adelfio R, Vargas M. Keiser J, et al. PLoS Negl Trop Dis. 2013;7(3):e2119. doi: 10.1371/journal.pntd.0002119. Epub 2013 Mar 21. PLoS Negl Trop Dis. 2013. PMID: 23556013 Free PMC article.
PRINCIPAL FINDINGS: We calculated an ED50 of 4.7 mg/kg for oxantel pamoate against T. muris in mice. Combinations of oxantel pamoate with pyrantel pamoate behaved antagonistically in vitro (combination index (CI) = 2.53). ...Oxantel pamoate (10 mg/kg) lacked …
PRINCIPAL FINDINGS: We calculated an ED50 of 4.7 mg/kg for oxantel pamoate against T. muris in mice. Combinations of oxantel p …
106 results