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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1987 1
1989 4
1990 6
1991 12
1992 9
1993 5
1994 7
1995 2
1996 6
1998 2
1999 2
2000 2
2001 1
2002 2
2005 1
2006 1
2024 0

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63 results

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Page 1
Agonistic and antagonistic properties of the bradykinin B2 receptor antagonist, Hoe 140, in isolated blood vessels from different species.
Félétou M, Germain M, Thurieau C, Fauchère JL, Canet E. Félétou M, et al. Br J Pharmacol. 1994 Jun;112(2):683-9. doi: 10.1111/j.1476-5381.1994.tb13130.x. Br J Pharmacol. 1994. PMID: 8075888 Free PMC article.
As bradykinin B2 receptor antagonists, Hoe 140 and NPC 567 were less potent in the sheep femoral artery than in the rabbit jugular vein. Neither Hoe 140 nor NPC 567 were agonists for the endothelial receptor.6. This study demonstrates that Hoe 140, a n …
As bradykinin B2 receptor antagonists, Hoe 140 and NPC 567 were less potent in the sheep femoral artery than in the rabbit jug …
[Bradykinin antagonist: current status and perspective].
Hirayama Y, Kayakiri H. Hirayama Y, et al. Nihon Yakurigaku Zasshi. 2002 Jan;119(1):45-53. doi: 10.1254/fpj.119.45. Nihon Yakurigaku Zasshi. 2002. PMID: 11862756 Review. Japanese.
B2 receptors are constitutively expressed and mediate most physiological actions of kinins, whereas B1 receptors are highly inducible upon inflammatory stimulation or tissue injury, suggesting that they are involved in inflammation and/or nociception. Only three peptide type B2 a …
B2 receptors are constitutively expressed and mediate most physiological actions of kinins, whereas B1 receptors are highly inducible upon i …
D-Arg-[Hyp3-D-Phe7]-bradykinin, a bradykinin antagonist, reduces mortality in a rat model of endotoxic shock.
Wilson DD, de Garavilla L, Kuhn W, Togo J, Burch RM, Steranka LR. Wilson DD, et al. Circ Shock. 1989 Feb;27(2):93-101. Circ Shock. 1989. PMID: 2706751
Intravenous administration of LPS resulted in a 38% drop in mean arterial pressure at 1 hr which was partially reversed by NPC 567. NPC 567 did not affect the moderate tachycardia observed following LPS. NPC 567 infusion at 8 nmol/kg/min …
Intravenous administration of LPS resulted in a 38% drop in mean arterial pressure at 1 hr which was partially reversed by NPC 567 …
Antinociceptive effects of bradykinin antagonists.
Steranka LR, DeHaas CJ, Vavrek RJ, Stewart JM, Enna SJ, Snyder SH. Steranka LR, et al. Eur J Pharmacol. 1987 Apr 14;136(2):261-2. doi: 10.1016/0014-2999(87)90723-0. Eur J Pharmacol. 1987. PMID: 3595726 Free article. No abstract available.
A bradykinin antagonist modifies allergen-induced mediator release and late bronchial responses in sheep.
Abraham WM, Burch RM, Farmer SG, Sielczak MW, Ahmed A, Cortes A. Abraham WM, et al. Am Rev Respir Dis. 1991 Apr;143(4 Pt 1):787-96. doi: 10.1164/ajrccm/143.4_Pt_1.787. Am Rev Respir Dis. 1991. PMID: 2008991
We assessed the role of bradykinin (BK) in allergen-induced early and late bronchial responses, airway inflammation, mediator release, and antigen-induced airway hyperresponsiveness in allergic sheep by studying the effects of the BK B2 receptor antagonist, NPC-567 …
We assessed the role of bradykinin (BK) in allergen-induced early and late bronchial responses, airway inflammation, mediator release, and a …
Inhaled porcine pancreatic elastase causes bronchoconstriction via a bradykinin-mediated mechanism.
Scuri M, Forteza R, Lauredo I, Sabater JR, Botvinnikova Y, Allegra L, Abraham WM. Scuri M, et al. J Appl Physiol (1985). 2000 Oct;89(4):1397-402. doi: 10.1152/jappl.2000.89.4.1397. J Appl Physiol (1985). 2000. PMID: 11007574 Free article.
To test this hypothesis, we measured lung resistance (RL) in sheep before and after inhalation of porcine pancreatic elastase (PPE) alone and after pretreatment with a bradykinin B(2) antagonist (NPC-567), the specific human elastase inhibitor ICI 200,355, the hista …
To test this hypothesis, we measured lung resistance (RL) in sheep before and after inhalation of porcine pancreatic elastase (PPE) alone an …
Evidence for participation of B1 and B2 kinin receptors in formalin-induced nociceptive response in the mouse.
Corrêa CR, Calixto JB. Corrêa CR, et al. Br J Pharmacol. 1993 Sep;110(1):193-8. doi: 10.1111/j.1476-5381.1993.tb13791.x. Br J Pharmacol. 1993. PMID: 8220879 Free PMC article.
Similar results were obtained with the B2 antagonists NPC 349 (D-Arg[Hyp3,Thi5,8-D-Phe7]-BK) and NPC 567 (D-Arg[Hyp3, D-Phe7]-BK) (0.2 and 0.6 nmol/paw). Higher concentrations of these antagonists (1 nmol/paw) failed to antagonize formalin-induced pain. 4. ...The B2 …
Similar results were obtained with the B2 antagonists NPC 349 (D-Arg[Hyp3,Thi5,8-D-Phe7]-BK) and NPC 567 (D-Arg[Hyp3, D-Phe7]- …
Mechanisms of metabisulfite-induced bronchoconstriction: evidence for bradykinin B2-receptor stimulation.
Mansour E, Ahmed A, Cortes A, Caplan J, Burch RM, Abraham WM. Mansour E, et al. J Appl Physiol (1985). 1992 May;72(5):1831-7. doi: 10.1152/jappl.1992.72.5.1831. J Appl Physiol (1985). 1992. PMID: 1318295
Therefore we used allergic sheep to determine whether MBS-induced bronchoconstriction 1) had a pharmacology similar to that previously seen with BK in this model, including protection by a BK B2-receptor antagonist, NPC-567, and 2) was associated with increased conc …
Therefore we used allergic sheep to determine whether MBS-induced bronchoconstriction 1) had a pharmacology similar to that previously seen …
Characterization of the bradykinin receptor in the human nasal airway using the binding of [125I]-Hoe 140.
Dear JW, Wirth K, Scadding GK, Foreman JC. Dear JW, et al. Br J Pharmacol. 1996 Nov;119(5):1054-62. doi: 10.1111/j.1476-5381.1996.tb15777.x. Br J Pharmacol. 1996. PMID: 8922758 Free PMC article.
The equilibrium dissociation constant calculated from these rate constants was 0.70 nM. 4. Bradykinin and the B2 receptor antagonists, NPC 567, NPC 17731, NPC 17761, [1-adamantane acetyl-D-Arg0, Hyp3, Thi5,8, D-Phe7]-bradykinin, WIN 64338 and Hoe 140 displaced [125I …
The equilibrium dissociation constant calculated from these rate constants was 0.70 nM. 4. Bradykinin and the B2 receptor antagonists, NP …
A competitive kinin receptor antagonist, [DArg0, Hyp3, DPhe7]-bradykinin, does not affect the response to nasal provocation with bradykinin.
Pongracic JA, Naclerio RM, Reynolds CJ, Proud D. Pongracic JA, et al. Br J Clin Pharmacol. 1991 Mar;31(3):287-94. doi: 10.1111/j.1365-2125.1991.tb05532.x. Br J Clin Pharmacol. 1991. PMID: 1647192 Free PMC article. Clinical Trial.
In two double-blind, placebo controlled studies, we tested the effects of intranasal administration of 500 micrograms of a competitive kinin receptor antagonist, [DArg0, Hyp3, DPhe7]-bradykinin (NPC 567), on the response to nasal provocation with 20 micrograms of br …
In two double-blind, placebo controlled studies, we tested the effects of intranasal administration of 500 micrograms of a competitive kinin …
63 results