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Year Number of Results
1994 2
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2006 4
2007 2
2008 5
2009 9
2010 6
2011 3
2012 8
2013 3
2014 3
2015 2
2016 4
2017 2
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2020 3
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62 results

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Page 1
Genetic analysis of obstructive sleep apnoea discovers a strong association with cardiometabolic health.
Strausz S, Ruotsalainen S, Ollila HM, Karjalainen J, Kiiskinen T, Reeve M, Kurki M, Mars N, Havulinna AS, Luonsi E, Mansour Aly D, Ahlqvist E, Teder-Laving M, Palta P, Groop L, Mägi R, Mäkitie A, Salomaa V, Bachour A, Tuomi T; FinnGen; Palotie A, Palotie T, Ripatti S. Strausz S, et al. Eur Respir J. 2021 May 6;57(5):2003091. doi: 10.1183/13993003.03091-2020. Print 2021 May. Eur Respir J. 2021. PMID: 33243845 Free article.
We aimed to identify genetic loci associated with OSA risk, and to test if OSA and its comorbidities share a common genetic background.We conducted the first large-scale genome-wide association study of OSA using the FinnGen study (217 955 individuals) with 16 761 OSA patients id …
We aimed to identify genetic loci associated with OSA risk, and to test if OSA and its comorbidities share a common genetic background.We co …
The WD40 repeat protein NEDD1 functions in microtubule organization during cell division in Arabidopsis thaliana.
Zeng CJ, Lee YR, Liu B. Zeng CJ, et al. Plant Cell. 2009 Apr;21(4):1129-40. doi: 10.1105/tpc.109.065953. Epub 2009 Apr 21. Plant Cell. 2009. PMID: 19383896 Free PMC article.
Although cells of flowering plants lack a structurally defined microtubule-organizing center like the centrosome, organization of the spindles and phragmoplasts in mitosis is known to involve the evolutionarily conserved gamma-tubulin complex. We have investigated the function of …
Although cells of flowering plants lack a structurally defined microtubule-organizing center like the centrosome, organization of the spindl …
The centrosome protein NEDD1 as a potential pharmacological target to induce cell cycle arrest.
Tillement V, Haren L, Roullet N, Etievant C, Merdes A. Tillement V, et al. Mol Cancer. 2009 Feb 25;8:10. doi: 10.1186/1476-4598-8-10. Mol Cancer. 2009. PMID: 19243593 Free PMC article.
BACKGROUND: NEDD1 is a protein that binds to the gamma-tubulin ring complex, a multiprotein complex at the centrosome and at the mitotic spindle that mediates the nucleation of microtubules. RESULTS: We show that NEDD1 is expressed at comparable levels in a v …
BACKGROUND: NEDD1 is a protein that binds to the gamma-tubulin ring complex, a multiprotein complex at the centrosome and at t …
NEDD1: function in microtubule nucleation, spindle assembly and beyond.
Manning J, Kumar S. Manning J, et al. Int J Biochem Cell Biol. 2007;39(1):7-11. doi: 10.1016/j.biocel.2006.08.012. Epub 2006 Sep 1. Int J Biochem Cell Biol. 2007. PMID: 17005434 Review.
NEDD1 has homologues across a range of species, being particularly conserved in a region of WD40 repeats contained in the amino-terminal half of the protein. ...There is still much unknown about the function of this protein and how it may be involved in devel …
NEDD1 has homologues across a range of species, being particularly conserved in a region of WD40 repeats contained in the amino-termi …
NEDD1-S411 phosphorylation plays a critical function in the coordination of microtubule nucleation during mitosis.
Timón Pérez K, Scrofani J, Vernos I. Timón Pérez K, et al. Biol Open. 2022 Nov 1;11(11):bio059474. doi: 10.1242/bio.059474. Epub 2022 Nov 17. Biol Open. 2022. PMID: 36318115 Free PMC article.
During mitosis, spindle assembly relies on centrosomal and acentrosomal microtubule nucleation pathways that all require the gamma-Tubulin Ring Complex (gamma-TuRC) and its adaptor protein NEDD1. The activity of these different pathways needs to be coordinated to en …
During mitosis, spindle assembly relies on centrosomal and acentrosomal microtubule nucleation pathways that all require the gamma-Tubulin R …
Novel NEDD1 phosphorylation sites regulate gamma-tubulin binding and mitotic spindle assembly.
Gomez-Ferreria MA, Bashkurov M, Helbig AO, Larsen B, Pawson T, Gingras AC, Pelletier L. Gomez-Ferreria MA, et al. J Cell Sci. 2012 Aug 15;125(Pt 16):3745-51. doi: 10.1242/jcs.105130. Epub 2012 May 17. J Cell Sci. 2012. PMID: 22595525
Several residues of NEDD1 are phosphorylated in mitosis. However, previously identified phosphorylation sites only partially regulate NEDD1 function, as NEDD1 depletion has a much stronger phenotype than mutation of these residues. ...We also found that CEP19 …
Several residues of NEDD1 are phosphorylated in mitosis. However, previously identified phosphorylation sites only partially regulate …
An essential function for the centrosomal protein NEDD1 in zebrafish development.
Manning JA, Lewis M, Koblar SA, Kumar S. Manning JA, et al. Cell Death Differ. 2010 Aug;17(8):1302-14. doi: 10.1038/cdd.2010.12. Epub 2010 Feb 12. Cell Death Differ. 2010. PMID: 20150915
Although the cellular roles of many centrosomal proteins are well defined, much less is known about their functions and the role of the centrosome in development. ...The zebrafish homologue of NEDD1 (zNEDD1) was cloned and found to have a similar localisation and fu …
Although the cellular roles of many centrosomal proteins are well defined, much less is known about their functions and the role of t …
PLK4-phosphorylated NEDD1 facilitates cartwheel assembly and centriole biogenesis initiations.
Chi W, Wang G, Xin G, Jiang Q, Zhang C. Chi W, et al. J Cell Biol. 2021 Jan 4;220(1):e202002151. doi: 10.1083/jcb.202002151. J Cell Biol. 2021. PMID: 33351100 Free PMC article.
We found that PLK4-mediated phosphorylation of NEDD1 at its S325 amino acid residue directly promotes both NEDD1 binding to SAS-6 and recruiting SAS-6 to the centrosome. Overexpression of phosphomimicking NEDD1 mutant S325E promoted cartwheel assembly and dau …
We found that PLK4-mediated phosphorylation of NEDD1 at its S325 amino acid residue directly promotes both NEDD1 binding to SA …
Nedd1 expression as a marker of dynamic centrosomal localization during mouse embryonic development.
Manning JA, Colussi PA, Koblar SA, Kumar S. Manning JA, et al. Histochem Cell Biol. 2008 Jun;129(6):751-64. doi: 10.1007/s00418-008-0392-0. Epub 2008 Feb 1. Histochem Cell Biol. 2008. PMID: 18239929
Currently, little is known about centrosomal dynamics during mammalian development. In this study, we have analyzed Nedd1 protein expression to characterize the localization of the centrosome during some aspects of mouse embryogenesis. Using a Nedd1 antibody …
Currently, little is known about centrosomal dynamics during mammalian development. In this study, we have analyzed Nedd1 protein …
NEDD1-dependent recruitment of the gamma-tubulin ring complex to the centrosome is necessary for centriole duplication and spindle assembly.
Haren L, Remy MH, Bazin I, Callebaut I, Wright M, Merdes A. Haren L, et al. J Cell Biol. 2006 Feb 13;172(4):505-15. doi: 10.1083/jcb.200510028. Epub 2006 Feb 6. J Cell Biol. 2006. PMID: 16461362 Free PMC article.
We characterize NEDD1, a centrosomal protein that associates with gammaTuRCs. We show that the majority of gammaTuRCs assemble even after NEDD1 depletion but require NEDD1 for centrosomal targeting. ...Similar spindle defects are obtained by overexpres …
We characterize NEDD1, a centrosomal protein that associates with gammaTuRCs. We show that the majority of gammaTuRCs assemble …
62 results