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Effect of linkage variation on pharmacokinetics of ricin A chain-antibody conjugates in normal rats.
Worrell NR, Cumber AJ, Parnell GD, Mirza A, Forrester JA, Ross WC. Worrell NR, et al. Anticancer Drug Des. 1986 Nov;1(3):179-88. Anticancer Drug Des. 1986. PMID: 3502450
Its preparation necessitated the synthesis of a new cross-linking reagent N-succinimidyl 3-(2-pyridyldithio)-butyrate. Conjugate 3 has a sulphide linkage and was prepared with the cross-linking reagent N-succinimidyl 4-(iodoacetylamino)be …
Its preparation necessitated the synthesis of a new cross-linking reagent N-succinimidyl 3-(2-pyridyldithio
Molecular and biological properties of an abrin A chain immunotoxin designed for therapy of human small cell lung cancer.
Wawrzynczak EJ, Zangemeister-Wittke U, Waibel R, Henry RV, Parnell GD, Cumber AJ, Jones M, Stahel RA. Wawrzynczak EJ, et al. Br J Cancer. 1992 Aug;66(2):361-6. doi: 10.1038/bjc.1992.271. Br J Cancer. 1992. PMID: 1323991 Free PMC article.
An immunotoxin (IT) comprising abrin A chain attached to the mouse monoclonal antibody SWA11, recognising a cell surface antigen highly associated with human small cell lung cancer (SCLC), was synthesised using a hindered disulphide crosslinker, N-succinimidyl 3
An immunotoxin (IT) comprising abrin A chain attached to the mouse monoclonal antibody SWA11, recognising a cell surface antigen highly asso …
Structural features of the antibody-A chain linkage that influence the activity and stability of ricin A chain immunotoxins.
Cumber AJ, Westwood JH, Henry RV, Parnell GD, Coles BF, Wawrzynczak EJ. Cumber AJ, et al. Bioconjug Chem. 1992 Sep-Oct;3(5):397-401. doi: 10.1021/bc00017a007. Bioconjug Chem. 1992. PMID: 1329989
Analogues of the standard ricin A chain immunotoxin prepared with the N-succinimidyl 3-(2-pyridyldithio)propionate disulfide cross-linker included immunoconjugates made with N-succinimidyl 4-[(iodoacetyl)amino]benzoate the thioether cross-linker; with N-succinimidyl
Analogues of the standard ricin A chain immunotoxin prepared with the N-succinimidyl 3-(2-pyridyldithio)propionate disulfide cross-linker in …