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The following term was not found in PubMed: 8-dimethylimidazo*4
Page 1
Characterization of DNA adducts formed in vitro by reaction of N-hydroxy-2-amino-3-methylimidazo[4,5-f]quinoline and N-hydroxy-2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline at the C-8 and N2 atoms of guanine.
Turesky RJ, Rossi SC, Welti DH, Lay JO Jr, Kadlubar FF. Turesky RJ, et al. Chem Res Toxicol. 1992 Jul-Aug;5(4):479-90. doi: 10.1021/tx00028a005. Chem Res Toxicol. 1992. PMID: 1391614
The covalent binding of the carcinogenic N-hydroxy metabolites of 2-amino-3-methylimidazo-[4,5-f]quinoline (IQ) and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) to deoxynucleosides and DNA was investigated in vitro. ...
The covalent binding of the carcinogenic N-hydroxy metabolites of 2-amino-3-methylimidazo-[4,5-f]quinoline (IQ) and 2-amino-3,8-dimethylimid …
Metabolism of the food-borne mutagen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in humans.
Turesky RJ, Garner RC, Welti DH, Richoz J, Leveson SH, Dingley KH, Turteltaub KW, Fay LB. Turesky RJ, et al. Chem Res Toxicol. 1998 Mar;11(3):217-25. doi: 10.1021/tx9701891. Chem Res Toxicol. 1998. PMID: 9544620 Clinical Trial.
The metabolism of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) was investigated in five human volunteers given a dietary equivalent of 14C-labeled MeIQx. ...Two metabolites were identified as the phase II conjugates N2-(3,8-dimethylimidazo[4,5-f]quin …
The metabolism of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) was investigated in five human volunteers given …
Bioactivation of the cooked food mutagen N-hydroxy-2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by estrogen sulfotransferase in cultured human mammary epithelial cells.
Lewis AJ, Walle UK, King RS, Kadlubar FF, Falany CN, Walle T. Lewis AJ, et al. Carcinogenesis. 1998 Nov;19(11):2049-53. doi: 10.1093/carcin/19.11.2049. Carcinogenesis. 1998. PMID: 9855023
In contrast, EST did not catalyze the DNA binding of two other cooked food mutagens, N-hydroxy-2-amino-3-methylimidazo[4,5-f]quinoline and N-hydroxy-2-amino-3,8-dimethylimidazo[4,5-f]quinoxalin
In contrast, EST did not catalyze the DNA binding of two other cooked food mutagens, N-hydroxy-2-amino-3- …
Carcinogenicity of the N-hydroxy derivative of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, 2-amino-3, 8-dimethyl-imidazo[4,5-f]quinoxaline and 3, 2'-dimethyl-4-aminobiphenyl in the rat.
Archer CL, Morse P, Jones RF, Shirai T, Haas GP, Wang CY. Archer CL, et al. Cancer Lett. 2000 Jul 3;155(1):55-60. doi: 10.1016/s0304-3835(00)00413-4. Cancer Lett. 2000. PMID: 10814879
., twice a week for 10 weeks with 50 micromol/kg of N-hydroxy-3, 2'-dimethyl-4-aminobiphenyl (N-OH-DMABP; Group II), N-OH-2-amino-3, 8-dimethylimidazo[4,5-f]quinoxaline (N-OH-MeIQx; Group III) or N-OH-2-amino-1-methyl-6-phenylimidaza-[4,5-b]pyridine (N-OH-PhI …
., twice a week for 10 weeks with 50 micromol/kg of N-hydroxy-3, 2'-dimethyl-4-aminobiphenyl (N-OH-DMABP; Group II), N-OH-2-amino-3, 8-dimet …
Metabolic activation of N-hydroxy arylamines and N-hydroxy heterocyclic amines by human sulfotransferase(s).
Chou HC, Lang NP, Kadlubar FF. Chou HC, et al. Cancer Res. 1995 Feb 1;55(3):525-9. Cancer Res. 1995. PMID: 7834621
Among the N-hydroxy derivatives studied, N-hydroxy-2-acetylaminofluorene, N-hydroxy-2-aminofluorene, N-hydroxy-4,4'-methylene-bis(2-chloroaniline), N-hydroxy-2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, and N-hydroxy-2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole were each …
Among the N-hydroxy derivatives studied, N-hydroxy-2-acetylaminofluorene, N-hydroxy-2-aminofluorene, N-hydroxy-4,4'-methylene-bis(2-chloroan …
Codominant expression of N-acetylation and O-acetylation activities catalyzed by N-acetyltransferase 2 in human hepatocytes.
Doll MA, Zang Y, Moeller T, Hein DW. Doll MA, et al. J Pharmacol Exp Ther. 2010 Aug;334(2):540-4. doi: 10.1124/jpet.110.168567. Epub 2010 Apr 29. J Pharmacol Exp Ther. 2010. PMID: 20430842 Free PMC article.

A robust and significant relationship was observed between deduced NAT2 phenotype (rapid, intermediate, or slow) and N-acetyltransferase activity toward sulfamethazine (p < 0.0001) and 4-aminobiphenyl (p < 0.0001) and for O-acetyltransferase-catalyzed metabolic activation o

A robust and significant relationship was observed between deduced NAT2 phenotype (rapid, intermediate, or slow) and N-acetyltransferase act …
The effect of the rs1799931 G857A (G286E) polymorphism on N-acetyltransferase 2-mediated carcinogen metabolism and genotoxicity differs with heterocyclic amine exposure.
Hein DW, Salazar-González RA, Doll MA, Zang Y. Hein DW, et al. Arch Toxicol. 2023 Oct;97(10):2697-2705. doi: 10.1007/s00204-023-03577-2. Epub 2023 Aug 18. Arch Toxicol. 2023. PMID: 37592049
NAT2 alleles possessing the T341C (I114T) or G857A (G286E) SNP were recombinant expressed in yeast and tested for capacity to catalyze the O-acetylation of the N-hydroxy metabolites of heterocyclic amines (HCAs). The T341C (I114T) SNP reduced the O-acetylation of N-hydr
NAT2 alleles possessing the T341C (I114T) or G857A (G286E) SNP were recombinant expressed in yeast and tested for capacity to catalyze the O …
4-Aminobiphenyl downregulation of NAT2 acetylator genotype-dependent N- and O-acetylation of aromatic and heterocyclic amine carcinogens in primary mammary epithelial cell cultures from rapid and slow acetylator rats.
Jefferson FA, Xiao GH, Hein DW. Jefferson FA, et al. Toxicol Sci. 2009 Jan;107(1):293-7. doi: 10.1093/toxsci/kfn216. Epub 2008 Oct 8. Toxicol Sci. 2009. PMID: 18842621 Free PMC article.
PABA, 2-aminofluorene, and 4-aminobiphenyl N-acetyltransferase and N-hydroxy-2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine and N-hydroxy-2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline O-acetyltransferase activities were tw …
PABA, 2-aminofluorene, and 4-aminobiphenyl N-acetyltransferase and N-hydroxy-2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine and N- …
Effects of single nucleotide polymorphisms in human N-acetyltransferase 2 on metabolic activation (O-acetylation) of heterocyclic amine carcinogens.
Hein DW, Fretland AJ, Doll MA. Hein DW, et al. Int J Cancer. 2006 Sep 1;119(5):1208-11. doi: 10.1002/ijc.21957. Int J Cancer. 2006. PMID: 16570281 Free PMC article.
N-Acetyltransferase 2 (NAT2) catalyzes the O-acetylation of N-hydroxy heterocyclic amines such as N-hydroxy-2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (N--OH--MeIQx) and N-hydroxy-2-amino-1-methyl-6-phenylimidazo[4,5-b] p …
N-Acetyltransferase 2 (NAT2) catalyzes the O-acetylation of N-hydroxy heterocyclic amines such as N-hydroxy-2-amino
Antimutagenic effects and possible mechanisms of action of vitamins and related compounds against genotoxic heterocyclic amines from cooked food.
Edenharder R, Worf-Wandelburg A, Decker M, Platt KL. Edenharder R, et al. Mutat Res. 1999 Jul 21;444(1):235-48. doi: 10.1016/s1383-5718(99)00098-4. Mutat Res. 1999. PMID: 10477359
., 2-amino-3-methyl-imidazo[4, 5-f]quinoline (IQ), 2-amino-3,4-dimethyl-imidazo[4,5-f]quinoline (MeIQ), 2-amino-3,8-dimethyl-imidazo[4,5-f]quinoxaline (MeIQx), 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), 2-amino-6-methyl-dipyrido[1,2-a:3',2'-d]imi …
., 2-amino-3-methyl-imidazo[4, 5-f]quinoline (IQ), 2-amino-3,4-dimethyl-imidazo[4,5-f]quinoline (MeIQ), 2-amino-3,8-dimethyl-imidazo[4,5
11 results