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Substrate tRNA recognition mechanism of a multisite-specific tRNA methyltransferase, Aquifex aeolicus Trm1, based on the X-ray crystal structure.
Awai T, Ochi A, Ihsanawati, Sengoku T, Hirata A, Bessho Y, Yokoyama S, Hori H. Awai T, et al. J Biol Chem. 2011 Oct 7;286(40):35236-46. doi: 10.1074/jbc.M111.253641. Epub 2011 Aug 15. J Biol Chem. 2011. PMID: 21844194 Free PMC article.
Archaeal and eukaryotic tRNA (N(2),N(2)-guanine)-dimethyltransferase (Trm1) produces N(2),N(2)-dimethylguanine at position 26 in tRNA. In contrast, Trm1 from Aquifex aeolicus, a hyper-thermophilic eubacterium, modifies G27 as well as G26. ...
Archaeal and eukaryotic tRNA (N(2),N(2)-guanine)-dimethyltransferase (Trm1) produces N(2),N(2)-dimethylguanine at posit …
Synthetic spectroscopic models related to coenzymes and base pairs. VII. Stacking interactions in tRNA; the "bend" at dimethylguanosine.
Iwamura H, Leonard NJ, Eisinger J. Iwamura H, et al. Proc Natl Acad Sci U S A. 1970 Apr;65(4):1025-32. doi: 10.1073/pnas.65.4.1025. Proc Natl Acad Sci U S A. 1970. PMID: 5266146 Free PMC article.
From the hypochromism exhibited by synthetic 9-[3-(aden-9-yl)propyl]-2-dimethylaminopurine-6-one (IV) and by 9-[3-(cytos-1-yl)propyl]2-dimethylaminopurin-6-one in aqueous solution (VI) it is appearent that the interaction is at least as great between the N(2)-dim …
From the hypochromism exhibited by synthetic 9-[3-(aden-9-yl)propyl]-2-dimethylaminopurine-6-one (IV) and by 9-[3-(cytos-1-yl)propyl]2-dimet …
Analysis of urinary nucleosides as potential tumor markers in human colorectal cancer by high performance liquid chromatography/electrospray ionization tandem mass spectrometry.
Hsu WY, Chen WT, Lin WD, Tsai FJ, Tsai Y, Lin CT, Lo WY, Jeng LB, Lai CC. Hsu WY, et al. Clin Chim Acta. 2009 Apr;402(1-2):31-7. doi: 10.1016/j.cca.2008.12.009. Epub 2008 Dec 16. Clin Chim Acta. 2009. PMID: 19135043
The mean levels of 5 urinary nucleosides (adenosine, cytidine, N(2),N(2)-dimethylguanine, 8-hydroxy-2'-deoxyguanosine and uridine) were significantly higher in the patients with colorectal cancer than in the healthy adults. ...
The mean levels of 5 urinary nucleosides (adenosine, cytidine, N(2),N(2)-dimethylguanine, 8-hydroxy-2'-deoxyguanosine a …
Effect of light on the nucleotide composition of rRNA of wheat seedlings.
Rácz I, Király I, Lásztily D. Rácz I, et al. Planta. 1978 Jan;142(3):263-7. doi: 10.1007/BF00385075. Planta. 1978. PMID: 24408187
Using different degradation methods and separation techniques the 18S+26S RNA of 8-day-old wheat seedlings grown in the light was found to contain 5-methylcytidine, 3-methylcytidine, 5-methyluridine, 3-methyluridine, 5-carboxymethyluridine, 1-methyladenine, N-methyladenine, 5-hyd …
Using different degradation methods and separation techniques the 18S+26S RNA of 8-day-old wheat seedlings grown in the light was found to c …
Transfer RNA methylating activity of yeast mitochondria.
Smolar N, Svensson I. Smolar N, et al. Nucleic Acids Res. 1974 May;1(5):707-18. doi: 10.1093/nar/1.5.707. Nucleic Acids Res. 1974. PMID: 10793751 Free PMC article.
The main reaction product, using E.coli tRNA as methyl group acceptor, is N(2),-N(2)-dimethylguanine. The corresponding mitochondrial methylase is coded by nuclear DNA. ...
The main reaction product, using E.coli tRNA as methyl group acceptor, is N(2),-N(2)-dimethylguanine. The corresponding …
On the methylated purine content of tRNA present in tumours.
Ho Y, Lin H. Ho Y, et al. Br J Cancer. 1974 Apr;29(4):324-7. doi: 10.1038/bjc.1974.74. Br J Cancer. 1974. PMID: 4853458 Free PMC article.
The molar proportions of 5 bases detected in acid hydrolysates of tumour tRNA (N(2)-methylguanine, 1-methylguanine, 7-methylguanine, N(2)-dimethylguanine and 1-methyladenine) were not abnormally elevated....
The molar proportions of 5 bases detected in acid hydrolysates of tumour tRNA (N(2)-methylguanine, 1-methylguanine, 7-methylguanine, N …
Characterization of a mutation in Saccharomyces cerevisiae that produces mutant isoaccepting tRNAs for several of its tRNA species : Physiological studies.
Lo RY, Bell JB. Lo RY, et al. Curr Genet. 1981 Apr;3(1):73-82. doi: 10.1007/BF00419583. Curr Genet. 1981. PMID: 24189955
Analysis of a double mutant that produces mia isoacceptors which also lack N(2)-dimethylguanine shows that some of the modifications to tRNA molecules need not follow a specific sequence....
Analysis of a double mutant that produces mia isoacceptors which also lack N(2)-dimethylguanine shows that some of the …