Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1989 1
1990 1
1991 1
2000 1
2024 0

Text availability

Article attribute

Article type

Publication date

Search Results

4 results

Results by year

Filters applied: . Clear all
Page 1
Effects of McN-6186 on voltage-dependent Ca++ channels in heart and pituitary cells.
Rampe D, Skattebøl A, Triggle DJ, Brown AM. Rampe D, et al. J Pharmacol Exp Ther. 1989 Jan;248(1):164-70. J Pharmacol Exp Ther. 1989. PMID: 2536427
In some ventricular cells tested, the T-type Ca++ current was also blocked by 2 microM McN-6186. McN-6186 inhibited (+)-[3H]PN200-110 binding in rat cardiac membranes with an IC50 value of 1.45 X 10(-7) M and a shallow Hill slope (nH = 0.42). ...Furthe …
In some ventricular cells tested, the T-type Ca++ current was also blocked by 2 microM McN-6186. McN-6186 inhibi …
Effects of the novel coronary selective calcium channel blocker, McN-6186, on cardiocirculatory dynamics, coronary vascular resistance, and cardiac output distribution in normal, conscious rats.
Flaim SF, Stranieri MT, Gill A, Carson JR, Brannan MD. Flaim SF, et al. J Cardiovasc Pharmacol. 1990 May;15(5):780-90. doi: 10.1097/00005344-199005000-00014. J Cardiovasc Pharmacol. 1990. PMID: 1692939
The purpose of this study was to characterize the cardiocirculatory effects of the novel calcium channel blocker, McN-6186 (McN), normal, conscious rats. Animals were instrumented under halothane anesthesia for right atrial, left ventricular, arterial, and venous pr …
The purpose of this study was to characterize the cardiocirculatory effects of the novel calcium channel blocker, McN-6186 (Mc …
Pharmacophore modelling of structurally unusual diltiazem mimics at L-type calcium channels.
Schleifer KJ, Tot E. Schleifer KJ, et al. J Comput Aided Mol Des. 2000 Jul;14(5):427-33. doi: 10.1023/a:1008188505899. J Comput Aided Mol Des. 2000. PMID: 10896315
Therefore, sterical and electronic characteristics of cis-/trans-diclofurime, the verapamil-like derivatives McN-5691 and McN-6186 as well as the natural products papaverine, laudanosine, antioquine and tetrandrine were compared with the pharmacophoric requirements …
Therefore, sterical and electronic characteristics of cis-/trans-diclofurime, the verapamil-like derivatives McN-5691 and McN-6186 …
Effects of Ca2+ channel ligands on [3H]QNB binding at m1 and m3 muscarinic receptors.
Kwon YW, Triggle DJ. Kwon YW, et al. Gen Pharmacol. 1991;22(2):267-70. doi: 10.1016/0306-3623(91)90445-c. Gen Pharmacol. 1991. PMID: 2055419
The IC50 values of Ca2+ channel ligands for the inhibition of [3H]QNB binding were between 10(-6) and 10(-4) M and the rank order of potency was HOE 166 greater than McN 6186 greater than nicardipine greater than tiamdipine greater than verapamil greater than diltia …
The IC50 values of Ca2+ channel ligands for the inhibition of [3H]QNB binding were between 10(-6) and 10(-4) M and the rank order of potency …