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Cytotoxic activity of maytanprine isolated from Maytenus diversifolia in human leukemia K562 cells.
Nakao H, Senokuchi K, Umebayashi C, Kanemaru K, Masuda T, Oyama Y, Yonemori S. Nakao H, et al. Biol Pharm Bull. 2004 Aug;27(8):1236-40. doi: 10.1248/bpb.27.1236. Biol Pharm Bull. 2004. PMID: 15305028 Free article.
The potency of maytanprine in inhibiting cell growth was greater than that of maytansine, although the inhibitory action of maytanprine was similar to that of maytansine. ...M. diversifolia is one natural source of maytanprine, which is more cytotoxic than ma …
The potency of maytanprine in inhibiting cell growth was greater than that of maytansine, although the inhibitory action of maytan …
Animal models of amyotrophic lateral sclerosis and the spinal muscular atrophies.
Sillevis Smitt PA, de Jong JM. Sillevis Smitt PA, et al. J Neurol Sci. 1989 Jul;91(3):231-58. doi: 10.1016/0022-510x(89)90056-7. J Neurol Sci. 1989. PMID: 2671267 Review.
Models based on experimentally induced disease, include heavy metals and trace elements (lead intoxication in guinea pigs, rabbits, rats, cats and primates; mercury intoxication in rats; aluminium intoxication in rabbits; swayback in goat kids; calcium and magnesium deficient rab …
Models based on experimentally induced disease, include heavy metals and trace elements (lead intoxication in guinea pigs, rabbits, rats, ca …
Induction of neurofibrillary tangles in cultured mouse neurons by maytanprine.
Sato Y, Kim SU, Ghetti B. Sato Y, et al. J Neurol Sci. 1985 May;68(2-3):191-203. doi: 10.1016/0022-510x(85)90100-5. J Neurol Sci. 1985. PMID: 4040155
Neurofibrillary (neurofilament) tangles were induced in cultured neurons of newborn mouse dorsal root ganglia by exposure to maytanprine, an anti-microtubule drug. By 12-24 h of treatment, small short neurofilament bundles were found in the neuronal perikarya and proximal …
Neurofibrillary (neurofilament) tangles were induced in cultured neurons of newborn mouse dorsal root ganglia by exposure to maytanprine …
Occurrence and spatial distribution of maytansinoids in Putterlickia pyracantha, an unexplored resource of anticancer compounds.
Eckelmann D, Kusari S, Spiteller M. Eckelmann D, et al. Fitoterapia. 2016 Sep;113:175-81. doi: 10.1016/j.fitote.2016.08.006. Epub 2016 Aug 10. Fitoterapia. 2016. PMID: 27521896
In addition to maytansine, which is already known to be present in this species, we show the presence of maytanprine, maytanbutine, maytanvaline, normaytancyprine and an abundant maytansine precursor in different tissues using high-resolution mass spectrometry. ...
In addition to maytansine, which is already known to be present in this species, we show the presence of maytanprine, maytanbutine, m …
Microbiological assays and bioautography of maytansine and its homologues.
Hanka LJ, Barnett MS. Hanka LJ, et al. Antimicrob Agents Chemother. 1974 Nov;6(5):651-2. doi: 10.1128/AAC.6.5.651. Antimicrob Agents Chemother. 1974. PMID: 15825322 Free PMC article.
A quantitative microbiological assay and a bioautography system with Penicillium avellaneum UC-4376 was developed for the antitumor drugs maytansine, and its homologues, maytanprine and maytanbutine. The susceptibility of the assay is 1.5 mug/ml....
A quantitative microbiological assay and a bioautography system with Penicillium avellaneum UC-4376 was developed for the antitumor drugs ma …