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Did you mean microcin OR 11049-15-3 [rn] (618 results)?
Evolving enzyme technology for pharmaceutical applications: case studies.
Yeh WK. Yeh WK. J Ind Microbiol Biotechnol. 1997 Nov-Dec;19(5-6):334-43. doi: 10.1038/sj.jim.2900437. J Ind Microbiol Biotechnol. 1997. PMID: 9451830 Review.
The case studies focus on two types of enzyme applications for pharmaceutical development. Demethylmacrocin O-methyltransferase, macrocin O-methyltransferase (both putatively rate-limiting) and tylosin reductase were purified from Streptomyces fradiae, characterized and th …
The case studies focus on two types of enzyme applications for pharmaceutical development. Demethylmacrocin O-methyltransferase, macrocin …
Characterization of the Two Methylation Steps Involved in the Biosynthesis of Mycinose in Tylosin.
Kim E, Song MC, Kim MS, Beom JY, Lee EY, Kim DM, Nam SJ, Yoon YJ. Kim E, et al. J Nat Prod. 2016 Aug 26;79(8):2014-21. doi: 10.1021/acs.jnatprod.6b00267. Epub 2016 Jul 25. J Nat Prod. 2016. PMID: 27453999
It has long been known that the TylE-catalyzed C2-O-methylation of the 6-deoxy-d-allose bound to demethylmacrocin or demethyllactenocin precedes the TylF-catalyzed C3-O-methylation of the d-javose (C2-O-methylated 6-deoxy-d-allose) attached to macrocin or lactenocin. This …
It has long been known that the TylE-catalyzed C2-O-methylation of the 6-deoxy-d-allose bound to demethylmacrocin or demethyllactenocin prec …
Properties of Streptomyces fradiae mutants blocked in biosynthesis of the macrolide antibiotic tylosin.
Baltz RH, Seno ET. Baltz RH, et al. Antimicrob Agents Chemother. 1981 Aug;20(2):214-25. doi: 10.1128/AAC.20.2.214. Antimicrob Agents Chemother. 1981. PMID: 7283418 Free PMC article.
Mutants blocked in specific steps other than 3''' O-methylation, including a mutant blocked in 2''' O-methylation of demethylmacrocin, produced normal levels of macrocin O-methyltransferase. Mutants apparently containing specific tylosin structural gene mutations produced …
Mutants blocked in specific steps other than 3''' O-methylation, including a mutant blocked in 2''' O-methylation of demethylmacrocin, produ …
Properties of S-adenosyl-L-methionine:macrocin O-methyltransferase in extracts of Streptomyces fradiae strains which produce normal or elevated levels of tylosin and in mutants blocked in specific O-methylations.
Seno ET, Baltz RH. Seno ET, et al. Antimicrob Agents Chemother. 1981 Sep;20(3):370-7. doi: 10.1128/AAC.20.3.370. Antimicrob Agents Chemother. 1981. PMID: 7305323 Free PMC article.
An efficient assay for S-adenosyl-L-methionine:macrocin O-methyltransferase, the enzyme which carries out the terminal step in tylosin biosynthesis, is described. ...Macrocin O-methyltransferase specifically converts macrocin to tylosin by O-methylation of th …
An efficient assay for S-adenosyl-L-methionine:macrocin O-methyltransferase, the enzyme which carries out the terminal step in tylosi …
S-Adenosyl-L-methionine: macrocin O-methyltransferase activities in a series of Streptomyces fradiae mutants that produce different levels of the macrolide antibiotic tylosin.
Seno ET, Baltz RH. Seno ET, et al. Antimicrob Agents Chemother. 1982 May;21(5):758-63. doi: 10.1128/AAC.21.5.758. Antimicrob Agents Chemother. 1982. PMID: 7103455 Free PMC article.
The most productive mutants, which synthesized elevated levels of macrocin O-methyltransferase, also produced large amounts of macrocin, the substrate for the enzyme. Incomplete conversion of macrocin to tylosin by these mutants may be due to substrate and pr …
The most productive mutants, which synthesized elevated levels of macrocin O-methyltransferase, also produced large amounts of mac …
Purification, characterization, and kinetic mechanism of S-adenosyl-L-methionine:macrocin O-methyltransferase from Streptomyces fradiae.
Bauer NJ, Kreuzman AJ, Dotzlaf JE, Yeh WK. Bauer NJ, et al. J Biol Chem. 1988 Oct 25;263(30):15619-25. J Biol Chem. 1988. PMID: 3170601 Free article.
S-Adenosyl-L-methionine:macrocin O-methyltransferase catalyzes conversion of macrocin to tylosin, the terminal and main rate-limiting step of tylosin biosynthesis in Streptomyces fradiae. ...Steady-state kinetic studies for initial velocity, substrate analogue, and …
S-Adenosyl-L-methionine:macrocin O-methyltransferase catalyzes conversion of macrocin to tylosin, the terminal and main rate-l …
Terminal stages in the biosynthesis of tylosin.
Seno ET, Pieper RL, Huber FM. Seno ET, et al. Antimicrob Agents Chemother. 1977 Mar;11(3):455-61. doi: 10.1128/AAC.11.3.455. Antimicrob Agents Chemother. 1977. PMID: 855999 Free PMC article.
Data obtained by the addition of the purified (14)C-labeled antibiotics to cultures of S. fradiae revealed that macrocin and desmycosin were direct precursors of tylosin, whereas lactenocin was an immediate precursor of both macrocin and desmycosin. ...The kinetics …
Data obtained by the addition of the purified (14)C-labeled antibiotics to cultures of S. fradiae revealed that macrocin and desmycos …
High-performance liquid chromatographic assay for S-adenosyl-L-methionine: macrocin O-methyltransferase.
Yeh WK, Bauer NJ, Dotzlaf JE. Yeh WK, et al. J Chromatogr. 1984 Apr 20;288(1):157-65. doi: 10.1016/s0021-9673(01)93690-8. J Chromatogr. 1984. PMID: 6725471
A high-performance liquid chromatographic (HPLC) procedure was developed to assay S-adenosyl-L-methionine: macrocin O-methyltransferase. This enzyme catalyzes the rate-limiting terminal reaction of tylosin biosynthesis in Streptomyces fradiae. ...
A high-performance liquid chromatographic (HPLC) procedure was developed to assay S-adenosyl-L-methionine: macrocin O-methyltransfera …
Biosynthesis of the macrolide antibiotic tylosin. A preferred pathway from tylactone to tylosin.
Baltz RH, Seno ET, Stonesifer J, Wild GM. Baltz RH, et al. J Antibiot (Tokyo). 1983 Feb;36(2):131-41. doi: 10.7164/antibiotics.36.131. J Antibiot (Tokyo). 1983. PMID: 6833128 Free article.
The results indicated that tylactone, the first intermediate excreted by Streptomyces fradiae, is converted to tylosin by a preferred sequence of reactions which include: (1) addition of mycaminose to the C-5 hydroxyl position of the lactone; (2) hydroxylation of the C-20 methyl …
The results indicated that tylactone, the first intermediate excreted by Streptomyces fradiae, is converted to tylosin by a preferred sequen …
26 results