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1983 1
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22 results

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Page 1
Cytochrome P-450-dependent 14 alpha-demethylation of lanosterol in Candida albicans.
Hitchcock CA, Brown SB, Evans EG, Adams DJ. Hitchcock CA, et al. Biochem J. 1989 Jun 1;260(2):549-56. doi: 10.1042/bj2600549. Biochem J. 1989. PMID: 2669735 Free PMC article.
Enzyme activity was decreased greatly when microsomes were treated with CO or the triazole antifungal ICI 153066....
Enzyme activity was decreased greatly when microsomes were treated with CO or the triazole antifungal ICI 153066....
Activities of the modified polyene N-D-ornithyl amphotericin methyl ester and the azoles ICI 153066, Bay n 7133, and Bay l 9139 compared with those of amphotericin B and ketoconazole in the therapy of experimental blastomycosis.
Lefler E, Brummer E, Perlman AM, Stevens DA. Lefler E, et al. Antimicrob Agents Chemother. 1985 Mar;27(3):363-6. doi: 10.1128/AAC.27.3.363. Antimicrob Agents Chemother. 1985. PMID: 3994350 Free PMC article.
Ketoconazole, previously the best azole drug studied and which is protective when administered orally, was superior to a new oral imidazole, Bay l 9139, and a new oral triazole, Bay n 7133. A new oral triazole, ICI 153066, was markedly more effective than ketoconazo …
Ketoconazole, previously the best azole drug studied and which is protective when administered orally, was superior to a new oral imidazole, …
Suppression of ATP in Candida albicans by imidazole and derivative antifungal agents.
Odds FC, Cheesman SL, Abbott AB. Odds FC, et al. Sabouraudia. 1985 Dec;23(6):415-24. Sabouraudia. 1985. PMID: 3913012
Relatively hydrophilic imidazole derivatives such as ketoconazole were essentially inactive in the test, as were the triazole derivatives fluconazole, ICI 153066, itraconazole and terconazole, and 5-fluorocytosine. ...
Relatively hydrophilic imidazole derivatives such as ketoconazole were essentially inactive in the test, as were the triazole derivatives fl …
Effects of imidazole- and triazole-derivative antifungal compounds on the growth and morphological development of Candida albicans hyphae.
Odds FC, Cockayne A, Hayward J, Abbott AB. Odds FC, et al. J Gen Microbiol. 1985 Oct;131(10):2581-9. doi: 10.1099/00221287-131-10-2581. J Gen Microbiol. 1985. PMID: 2999296
At 10(-7) M and higher concentrations, clotrimazole and miconazole strongly suppressed emergence of new hyphal outgrowths from parent yeast cells, whereas ICI 153066 and itraconazole had little effect on this phenomenon and ketoconazole and tioconazole had intermedi …
At 10(-7) M and higher concentrations, clotrimazole and miconazole strongly suppressed emergence of new hyphal outgrowths from parent yeast …
Improved method for estimation of azole antifungal inhibitory concentrations against Candida species, based on azole/antibiotic interactions.
Odds FC, Abbott AB, Pye G, Troke PF. Odds FC, et al. J Med Vet Mycol. 1986 Aug;24(4):305-11. doi: 10.1080/02681218680000461. J Med Vet Mycol. 1986. PMID: 3746584
Low, reproducible minimal inhibitory concentrations against Candida species, with sharp, precise end points in complex media were achieved for imidazoles (clotrimazole, econazole, miconazole, tioconazole and ketoconazole) and triazoles (fluconazole, itraconazole, vibunazole, I …
Low, reproducible minimal inhibitory concentrations against Candida species, with sharp, precise end points in complex media were achieved f …
Interaction of azole antifungal antibiotics with cytochrome P-450-dependent 14 alpha-sterol demethylase purified from Candida albicans.
Hitchcock CA, Dickinson K, Brown SB, Evans EG, Adams DJ. Hitchcock CA, et al. Biochem J. 1990 Mar 1;266(2):475-80. doi: 10.1042/bj2660475. Biochem J. 1990. PMID: 2180400 Free PMC article.
The interaction of azole antifungal antibiotics with purified Candida albicans cytochrome P-450-dependent 14 alpha-sterol demethylase (P-450DM) was measured spectrophotometrically and by inhibition of enzyme activity. Ketoconazole and ICI 153066 (a triazole derivati …
The interaction of azole antifungal antibiotics with purified Candida albicans cytochrome P-450-dependent 14 alpha-sterol demethylase (P-450 …
Antimycotic therapy of experimental infections caused by dematiaceous fungi.
Polak A. Polak A. Sabouraudia. 1984;22(4):279-89. doi: 10.1080/00362178485380481. Sabouraudia. 1984. PMID: 6095469
In the acute Wangiella infection amphotericin B also showed therapeutic activity whereas in the Fonsecaea model the effect was weak. The azole derivative ICI 153066 was the most efficacious drug in the Wangiella model whereas ketoconazole was inactive. ...
In the acute Wangiella infection amphotericin B also showed therapeutic activity whereas in the Fonsecaea model the effect was weak. The azo …
Inhibition of 14 alpha-sterol demethylase activity in Candida albicans Darlington does not correlate with resistance to azole.
Hitchcock CA, Barrett-Bee KJ, Russell NJ. Hitchcock CA, et al. J Med Vet Mycol. 1987 Oct;25(5):329-33. J Med Vet Mycol. 1987. PMID: 3323450
The 14 alpha-sterol demethylase in the azole-resistant Candida albicans, strain Darlington, is less sensitive to the triazole ICI 153066 than are two azole-sensitive strains, A and B. However, there is no direct correlation between the IC50 values for triazole inhib …
The 14 alpha-sterol demethylase in the azole-resistant Candida albicans, strain Darlington, is less sensitive to the triazole ICI …
22 results