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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1979 1
1982 1
1983 1
1984 2
1985 12
1986 2
1987 19
1988 6
1989 4
1990 2
1991 5
1992 3
1993 2
1994 9
1995 6
1996 6
1997 7
1998 9
1999 4
2000 14
2001 4
2002 6
2003 5
2004 7
2005 2
2006 10
2007 8
2008 14
2009 14
2010 18
2011 22
2012 19
2013 23
2014 21
2015 30
2016 19
2017 16
2018 20
2019 17
2020 11
2021 12
2022 10
2023 11
2024 1

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394 results

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Page 1
Hyperexcitable arousal circuits drive sleep instability during aging.
Li SB, Damonte VM, Chen C, Wang GX, Kebschull JM, Yamaguchi H, Bian WJ, Purmann C, Pattni R, Urban AE, Mourrain P, Kauer JA, Scherrer G, de Lecea L. Li SB, et al. Science. 2022 Feb 25;375(6583):eabh3021. doi: 10.1126/science.abh3021. Epub 2022 Feb 25. Science. 2022. PMID: 35201886 Free PMC article.
Disruption of Kcnq2/3 genes in Hcrt neurons of young mice destabilized sleep, mimicking aging-associated sleep fragmentation, whereas the KCNQ-selective activator flupirtine hyperpolarized Hcrt neurons and rejuvenated sleep architecture in aged mice. ...
Disruption of Kcnq2/3 genes in Hcrt neurons of young mice destabilized sleep, mimicking aging-associated sleep fragmentation, whereas the KC …
The pharmacological management of chronic lower back pain.
Migliorini F, Maffulli N, Eschweiler J, Betsch M, Catalano G, Driessen A, Tingart M, Baroncini A. Migliorini F, et al. Expert Opin Pharmacother. 2021 Jan;22(1):109-119. doi: 10.1080/14656566.2020.1817384. Epub 2020 Sep 4. Expert Opin Pharmacother. 2021. PMID: 32885995
The present systematic review investigated the efficacy of various pharmacological compounds to achieve pain relief and improve disability in chronic LBP patients. The present study focused on acetaminophen, amoxicillin, flupirtine, baclofen, tryciclic antidepressants (TCA …
The present systematic review investigated the efficacy of various pharmacological compounds to achieve pain relief and improve disability i …
Neurobiology of organophosphate-induced seizures.
Williamson J, Singh T, Kapur J. Williamson J, et al. Epilepsy Behav. 2019 Dec;101(Pt B):106426. doi: 10.1016/j.yebeh.2019.07.027. Epub 2019 Aug 6. Epilepsy Behav. 2019. PMID: 31399343 Review.
Muscarinic receptors exert this action by inhibiting specific KCNQ2/3 potassium channels, which mediate the M-current. Flupirtine, a drug that open channels, is effective against OP-induced seizures. ...
Muscarinic receptors exert this action by inhibiting specific KCNQ2/3 potassium channels, which mediate the M-current. Flupirtine, a …
Pregabalin can interact synergistically with Kv7 channel openers to exert antinociception in mice.
Huang CN, Chen YM, Xiao XY, Zhou HL, Zhu J, Qin HM, Jiang X, Li Z, Zhuang T, Zhang GS. Huang CN, et al. Eur J Pharmacol. 2023 Sep 5;954:175870. doi: 10.1016/j.ejphar.2023.175870. Epub 2023 Jun 22. Eur J Pharmacol. 2023. PMID: 37353189
Furthermore, the antinociceptive effects of pregabalin, flupirtine/retigabine, and their combinations were significantly attenuated by the Kv7 channel blocker XE991. ...Collectively, our results support the potential use of pregabalin in combination with flupirtine …
Furthermore, the antinociceptive effects of pregabalin, flupirtine/retigabine, and their combinations were significantly attenuated b …
Treatment of spasticity.
Rösche J. Rösche J. Spinal Cord. 2002 Jun;40(6):261-2. doi: 10.1038/sj.sc.3101313. Spinal Cord. 2002. PMID: 12037705 No abstract available.
Flupirtine in pain management: pharmacological properties and clinical use.
Devulder J. Devulder J. CNS Drugs. 2010 Oct;24(10):867-81. doi: 10.2165/11536230-000000000-00000. CNS Drugs. 2010. PMID: 20839897 Review.
Flupirtine displays superior tolerability when compared with tramadol and pentazocine. ...With respect to its molecular structure, mechanism of action and adverse event profile, flupirtine is a unique drug. Flupirtine is an analgesic with many potential thera …
Flupirtine displays superior tolerability when compared with tramadol and pentazocine. ...With respect to its molecular structure, me …
Chemical modulation of Kv7 potassium channels.
Borgini M, Mondal P, Liu R, Wipf P. Borgini M, et al. RSC Med Chem. 2021 Jan 14;12(4):483-537. doi: 10.1039/d0md00328j. eCollection 2021 Apr 28. RSC Med Chem. 2021. PMID: 34046626 Free PMC article. Review.
A large number of therapeutic applications are, in part, based on the clinical experience with two broad-spectrum Kv7 agonists, flupirtine and retigabine. Since precise molecular structures of human Kv7 channel subtypes in closed and open states have only very recently sta …
A large number of therapeutic applications are, in part, based on the clinical experience with two broad-spectrum Kv7 agonists, flupirtin …
Targeting Kv7 channels in pain pathways.
Rivera-Arconada I, Vicente-Baz J, Lopez-Garcia JA. Rivera-Arconada I, et al. Oncotarget. 2017 Feb 21;8(8):12554-12555. doi: 10.18632/oncotarget.15261. Oncotarget. 2017. PMID: 28199957 Free PMC article. No abstract available.
Flupirtine, a re-discovered drug, revisited.
Szelenyi I. Szelenyi I. Inflamm Res. 2013 Mar;62(3):251-8. doi: 10.1007/s00011-013-0592-5. Epub 2013 Jan 16. Inflamm Res. 2013. PMID: 23322112 Review.
Flupirtine was developed long before K(V)7 (KCNQ) channels were known. However, it was clear from the beginning that flupirtine is neither an opioid nor a nonsteroidal anti-inflammatory analgesic. ...
Flupirtine was developed long before K(V)7 (KCNQ) channels were known. However, it was clear from the beginning that flupirtine …
Neuroprotective effect of flupirtine in prion disease.
Schröder HC, Müller WE. Schröder HC, et al. Drugs Today (Barc). 2002 Jan;38(1):49-58. doi: 10.1358/dot.2002.38.1.660505. Drugs Today (Barc). 2002. PMID: 12532184 Review.
This drug acts as an N-methyl-D-aspartate (NMDA) antagonist, but does not bind to NMDA receptors. Flupirtine normalizes the level of intracellular glutathione and increases the expression of the antiapoptotic Bcl-2 protein in neuronal cells exposed to prion protein. In vie …
This drug acts as an N-methyl-D-aspartate (NMDA) antagonist, but does not bind to NMDA receptors. Flupirtine normalizes the level of …
394 results