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Page 1
Anti-apoptotic actions of the platelet-activating factor acetylhydrolase I alpha2 catalytic subunit.
Bonin F, Ryan SD, Migahed L, Mo F, Lallier J, Franks DJ, Arai H, Bennett SA. Bonin F, et al. J Biol Chem. 2004 Dec 10;279(50):52425-36. doi: 10.1074/jbc.M410967200. Epub 2004 Sep 28. J Biol Chem. 2004. PMID: 15456758 Free article.
To block PAF receptor-independent death pathway, we screened a panel of PAF antagonists (CV-3988, CV-6209, BN 52021, and FR 49175). BN 52021 and FR 49175 accelerated PAF hydrolysis and inhibited PAF-mediated caspase 3 activation. ...
To block PAF receptor-independent death pathway, we screened a panel of PAF antagonists (CV-3988, CV-6209, BN 52021, and FR 49175 …
Platelet activating factor-induced neuronal apoptosis is initiated independently of its G-protein coupled PAF receptor and is inhibited by the benzoate orsellinic acid.
Ryan SD, Harris CS, Mo F, Lee H, Hou ST, Bazan NG, Haddad PS, Arnason JT, Bennett SA. Ryan SD, et al. J Neurochem. 2007 Oct;103(1):88-97. doi: 10.1111/j.1471-4159.2007.04740.x. J Neurochem. 2007. PMID: 17877634 Free article.
To intervene in PAFR-independent neurotoxicity, the anti-apoptotic actions of three structurally distinct PAF antagonists were compared to a panel of plant and fungal benzoic acid derivatives. We found that the PAF antagonist BN 52021 but not FR 49175 or CV 3988 inh …
To intervene in PAFR-independent neurotoxicity, the anti-apoptotic actions of three structurally distinct PAF antagonists were compared to a …
Involvement of Sulfur in the Biosynthesis of Essential Metabolites in Pathogenic Fungi of Animals, Particularly Aspergillus spp.: Molecular and Therapeutic Implications.
Traynor AM, Sheridan KJ, Jones GW, Calera JA, Doyle S. Traynor AM, et al. Front Microbiol. 2019 Dec 13;10:2859. doi: 10.3389/fmicb.2019.02859. eCollection 2019. Front Microbiol. 2019. PMID: 31921039 Free PMC article. Review.
In fact, DTG is a substrate for both GliT and a bis-thiomethyltransferase, GtmA. GtmA converts DTG to bisdethiobis(methylthio)gliotoxin (BmGT), using 2 mol SAM and resultant SAH must be re-converted to SAM via the action of the Methyl/Met cycle. ...
In fact, DTG is a substrate for both GliT and a bis-thiomethyltransferase, GtmA. GtmA converts DTG to bisdethiobis(methylthio) …
Integration of In Silico and In Vitro Analysis of Gliotoxin Production Reveals a Narrow Range of Producing Fungal Species.
Redrado S, Esteban P, Domingo MP, Lopez C, Rezusta A, Ramirez-Labrada A, Arias M, Pardo J, Galvez EM. Redrado S, et al. J Fungi (Basel). 2022 Mar 31;8(4):361. doi: 10.3390/jof8040361. J Fungi (Basel). 2022. PMID: 35448592 Free PMC article.
Using bioinformatic tools, we have identified homologous gli gene clusters similar to the A. fumigatus GT gene cluster in several fungal species. In silico study led to in vitro confirmation of GT and Bisdethiobis(methylthio)gliotoxin (bmGT) production in fun …
Using bioinformatic tools, we have identified homologous gli gene clusters similar to the A. fumigatus GT gene cluster in several fungal spe …
Separation of five diketopiperazines from the marine fungus Alternaria alternate HK-25 by high-speed counter-current chromatography.
He X, Ding L, Yi M, Xu J, Zhou X, Zhang W, He S. He X, et al. J Sep Sci. 2019 Aug;42(15):2510-2516. doi: 10.1002/jssc.201801284. Epub 2019 Jun 17. J Sep Sci. 2019. PMID: 31127863
Where 151.6 mg of crude sample yielded five diketoperazines, 12,13-dihydroxy-fumitremorgin C (1), gliotoxin (2), demethoxyfum itremorgin C (3), bisdethiobis(methylthio)gliotoxin (4), fumitremorgin C (5), and the purities of all compounds were above 94% as det …
Where 151.6 mg of crude sample yielded five diketoperazines, 12,13-dihydroxy-fumitremorgin C (1), gliotoxin (2), demethoxyfum itremorgin C ( …
Regulation of nonribosomal peptide synthesis: bis-thiomethylation attenuates gliotoxin biosynthesis in Aspergillus fumigatus.
Dolan SK, Owens RA, O'Keeffe G, Hammel S, Fitzpatrick DA, Jones GW, Doyle S. Dolan SK, et al. Chem Biol. 2014 Aug 14;21(8):999-1012. doi: 10.1016/j.chembiol.2014.07.006. Chem Biol. 2014. PMID: 25126990
Like many other disulfide-containing epipolythiodioxopiperazines, a bis-thiomethylated form is also produced. In the case of gliotoxin, bisdethiobis(methylthio)gliotoxin (BmGT) is formed for unknown reasons by a cryptic enzyme. ...
Like many other disulfide-containing epipolythiodioxopiperazines, a bis-thiomethylated form is also produced. In the case of gliotoxin, b …
Interplay between Gliotoxin Resistance, Secretion, and the Methyl/Methionine Cycle in Aspergillus fumigatus.
Owens RA, O'Keeffe G, Smith EB, Dolan SK, Hammel S, Sheridan KJ, Fitzpatrick DA, Keane TM, Jones GW, Doyle S. Owens RA, et al. Eukaryot Cell. 2015 Sep;14(9):941-57. doi: 10.1128/EC.00055-15. Epub 2015 Jul 6. Eukaryot Cell. 2015. PMID: 26150413 Free PMC article.
Here we show that an A. fumigatus deltagliA strain is completely deficient in gliotoxin secretion but still retains the ability to efflux bisdethiobis(methylthio)gliotoxin (BmGT). This correlates with a significant increase in sensitivity to exogenous gliotox …
Here we show that an A. fumigatus deltagliA strain is completely deficient in gliotoxin secretion but still retains the ability to efflux …
Bis(methyl)gliotoxin proves to be a more stable and reliable marker for invasive aspergillosis than gliotoxin and suitable for use in diagnosis.
Domingo MP, Colmenarejo C, Martínez-Lostao L, Müllbacher A, Jarne C, Revillo MJ, Delgado P, Roc L, Meis JF, Rezusta A, Pardo J, Gálvez EM. Domingo MP, et al. Diagn Microbiol Infect Dis. 2012 May;73(1):57-64. doi: 10.1016/j.diagmicrobio.2012.01.012. Epub 2012 Apr 4. Diagn Microbiol Infect Dis. 2012. PMID: 22480566
15 results