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1982 1
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Page 1
Postsynaptic dopamine agonistic effects of 3-PPP enantiomers revealed by bilateral 6-hydroxy-dopamine lesions and by chronic reserpine treatment in rats.
Arnt J, Hyttel J. Arnt J, et al. J Neural Transm. 1984;60(3-4):205-23. doi: 10.1007/BF01249094. J Neural Transm. 1984. PMID: 6441835
The motor effects of some DA autoreceptor agonists and apomorphine in rats with bilateral 6-hydroxydopamine lesions of the median forebrain bundle were studied. Whereas (-)-3-PPP, (+)-3-phenethyl-PP and EMD 23448 decreased motility in sham-operated controls, a prono …
The motor effects of some DA autoreceptor agonists and apomorphine in rats with bilateral 6-hydroxydopamine lesions of the median forebrain …
Effects on body temperature in mice differentiate between dopamine D2 receptor agonists with high and low efficacies.
Sánchez C, Arnt J. Sánchez C, et al. Eur J Pharmacol. 1992 Jan 28;211(1):9-14. doi: 10.1016/0014-2999(92)90254-2. Eur J Pharmacol. 1992. PMID: 1352251
Quinpirole and (+)-3-(3-hydroxyphenyl)-N-n-propylpiperidine ((+)-3-PPP) induced a less pronounced hypothermia (1.7 and 1.5 degrees C), and preclamol ((-)-3-PPP), terguride and 3-(4-(4-phenyl-1,2,3,6-tetrahydropyridyl) …
Quinpirole and (+)-3-(3-hydroxyphenyl)-N-n-propylpiperidine ((+)-3-PPP) induced a less pronounced hypothermia (1.7 and 1.5 degrees C), and p …
Regulation of dopaminergic activity, but not tyrosine hydroxylase, is diminished after chronic inorganic lead exposure.
Lasley SM. Lasley SM. Neurotoxicology. 1992 Fall;13(3):625-35. Neurotoxicology. 1992. PMID: 1361980
Offspring were weaned to and maintained on the same solution given their dams until termination at 60 or 120 days. Rats were given saline or one of three DA agonists (EMD 23448, CGS 15855A, TL-99) 45 or 60 min before termination followed 15 min later by 750 mg/kg i. …
Offspring were weaned to and maintained on the same solution given their dams until termination at 60 or 120 days. Rats were given saline or …
Dopamine D-2 agonists with high and low efficacies: differentiation by behavioural techniques.
Arnt J, Hyttel J. Arnt J, et al. J Neural Transm Gen Sect. 1990;80(1):33-50. doi: 10.1007/BF01245021. J Neural Transm Gen Sect. 1990. PMID: 2137705
The effects of the dopamine (DA) D-2 antagonist YM 09151-2 and the DA D-2 agonists terguride, preclamol, EMD 23448, B-HT 920, quinpirole and (-)-NPA were studied in a battery of behavioural tests in order to evaluate their relative efficacies. ...After combination w …
The effects of the dopamine (DA) D-2 antagonist YM 09151-2 and the DA D-2 agonists terguride, preclamol, EMD 23448, B-HT 920, …
Synergistic interaction between dopamine D-1 and D-2 receptor agonists: circling behaviour of rats with hemitransection.
Arnt J, Perregaard J. Arnt J, et al. Eur J Pharmacol. 1987 Nov 3;143(1):45-53. doi: 10.1016/0014-2999(87)90733-3. Eur J Pharmacol. 1987. PMID: 3500865
A range of partial (autoreceptor) D-2 agonists, i.e. (-)-3-PPP, (+)-3-phenethyl-PP, terguride, EMD 23448 and B-HT 920 were all ineffective as was the alpha 2-adrenoceptor agonist clonidine. ...
A range of partial (autoreceptor) D-2 agonists, i.e. (-)-3-PPP, (+)-3-phenethyl-PP, terguride, EMD 23448 and B-HT 920 were all …
Relative dopamine D1 and D2 receptor affinity and efficacy determine whether dopamine agonists induce hyperactivity or oral stereotypy in rats.
Arnt J, Bøgesø KP, Hyttel J, Meier E. Arnt J, et al. Pharmacol Toxicol. 1988 Mar;62(3):121-30. doi: 10.1111/j.1600-0773.1988.tb01859.x. Pharmacol Toxicol. 1988. PMID: 3259694
Maximum stereotypies were induced by combination of SK & F 38393 and a series of D2 agonists, including full agonists and the partial D2 agonist B-HT 920, whereas partial agonists with low intrinsic activity (e.g. (-)-3-PPP, EMD 23448) did not induce stereotypie …
Maximum stereotypies were induced by combination of SK & F 38393 and a series of D2 agonists, including full agonists and the partial D2 …
Repeated stimulation of dopamine D2-like receptors: reduced responsiveness of nigrostriatal and mesoaccumbens dopamine neurons to quinpirole.
Pitts DK, Wang L, Kelland MD, Freeman AS, Chiodo LA. Pitts DK, et al. J Pharmacol Exp Ther. 1995 Oct;275(1):412-21. J Pharmacol Exp Ther. 1995. PMID: 7562579
Repeated 14-day i.p. treatment with the dopamine D2-like receptor agonists, quinpirole (2 mg/kg/day) or EMD 23448 (2.6 mg/kg/day), resulted in a significant decrease in the average potency and efficacy of i.v. quinpirole (cumulative doses administered on day 15) to …
Repeated 14-day i.p. treatment with the dopamine D2-like receptor agonists, quinpirole (2 mg/kg/day) or EMD 23448 (2.6 mg/kg/d …
Two automated locomotor activity tests for dopamine autoreceptor agonists.
Schreur PJ, Nichols NF. Schreur PJ, et al. Pharmacol Biochem Behav. 1986 Jul;25(1):255-61. doi: 10.1016/0091-3057(86)90263-7. Pharmacol Biochem Behav. 1986. PMID: 2875471
Apomorphine HCl, NPA, and (+)3-PPP antagonized amphetamine-stimulated locomotor behavior (total distance) without antagonizing apomorphine-stimulated behavior, suggesting a presynaptic dopamine autoreceptor agonism. EMD 23448 gave equivocal activity. On the other ha …
Apomorphine HCl, NPA, and (+)3-PPP antagonized amphetamine-stimulated locomotor behavior (total distance) without antagonizing apomorphine-s …
Effects of dopamine autoreceptor stimulation on the release of colocalized transmitters: in vivo release of dopamine and neurotensin from rat prefrontal cortex.
Bean AJ, During MJ, Roth RH. Bean AJ, et al. Neurosci Lett. 1990 Jan 1;108(1-2):143-8. doi: 10.1016/0304-3940(90)90721-k. Neurosci Lett. 1990. PMID: 2304623 Free article.
Following stimulation of dopamine autoreceptors with either apomorphine (30 micrograms/kg, s.c.) or EMD-23448 (10 microM in the perfusion buffer) a decrease in dopamine and an increase in neurotensin release was observed. ...
Following stimulation of dopamine autoreceptors with either apomorphine (30 micrograms/kg, s.c.) or EMD-23448 (10 microM in th …
24 results