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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1926 1
1928 2
1932 2
1937 3
1938 1
1939 1
1941 1
1942 2
1943 1
1944 1
1946 3
1947 4
1948 6
1949 5
1950 4
1951 8
1952 7
1953 10
1954 2
1955 7
1956 13
1957 16
1958 10
1959 14
1960 20
1961 38
1962 97
1963 176
1964 227
1965 205
1966 236
1967 281
1968 278
1969 368
1970 640
1971 853
1972 888
1973 891
1974 908
1975 878
1976 848
1977 776
1978 685
1979 648
1980 624
1981 563
1982 596
1983 536
1984 642
1985 607
1986 587
1987 647
1988 546
1989 602
1990 687
1991 668
1992 672
1993 713
1994 595
1995 704
1996 669
1997 689
1998 676
1999 757
2000 846
2001 709
2002 778
2003 807
2004 808
2005 840
2006 917
2007 859
2008 910
2009 923
2010 1001
2011 1039
2012 1104
2013 1142
2014 1159
2015 1159
2016 1149
2017 1147
2018 1152
2019 1185
2020 1314
2021 1389
2022 1232
2023 1144
2024 440

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45,144 results

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Page 1
Half a century of L-DOPA.
Mena MA, Casarejos MJ, Solano RM, de Yébenes JG. Mena MA, et al. Curr Top Med Chem. 2009;9(10):880-93. Curr Top Med Chem. 2009. PMID: 19754400 Review.
L-DOPA, when administered to mammals, is rapidly metabolized to dopamine and 3-OM-DOPA, and its half-life in plasma is roughly 2 hours which has been considered the explanation for some of the L-DOPA related complications in PD. There have been, therefore, so …
L-DOPA, when administered to mammals, is rapidly metabolized to dopamine and 3-OM-DOPA, and its half-life in plasma is roughly …
iPSC-based modeling of THD recapitulates disease phenotypes and reveals neuronal malformation.
Tristán-Noguero A, Fernández-Carasa I, Calatayud C, Bermejo-Casadesús C, Pons-Espinal M, Colini Baldeschi A, Campa L, Artigas F, Bortolozzi A, Domingo-Jiménez R, Ibáñez S, Pineda M, Artuch R, Raya Á, García-Cazorla À, Consiglio A. Tristán-Noguero A, et al. EMBO Mol Med. 2023 Mar 8;15(3):e15847. doi: 10.15252/emmm.202215847. Epub 2023 Feb 6. EMBO Mol Med. 2023. PMID: 36740977 Free PMC article.
Affected children present with either a severe form that does not respond to L-Dopa treatment (THD-B) or a milder L-Dopa responsive form (THD-A). ...Interestingly, L-Dopa treatment at the stage of neuronal precursors could prevent the alterations in THDB-iPSC …
Affected children present with either a severe form that does not respond to L-Dopa treatment (THD-B) or a milder L-Dopa respo …
L-Dopa in small peptides: an amazing functionality to form supramolecular materials.
Giuri D, Ravarino P, Tomasini C. Giuri D, et al. Org Biomol Chem. 2021 Jun 2;19(21):4622-4636. doi: 10.1039/d1ob00378j. Org Biomol Chem. 2021. PMID: 33978030 Review.
l-Dopa (3,4-dihydroxyphenylalanine) is a chiral amino acid generated via biosynthesis from l-tyrosine in plants and some animals. The presence of multiple interacting sites makes l-Dopa a multifunctional building block for the preparation of supramolecular ma …
l-Dopa (3,4-dihydroxyphenylalanine) is a chiral amino acid generated via biosynthesis from l-tyrosine in plants and some anima …
Restorative cell and gene therapies for Parkinson's disease.
Barker RA, Björklund A. Barker RA, et al. Handb Clin Neurol. 2023;193:211-226. doi: 10.1016/B978-0-323-85555-6.00012-6. Handb Clin Neurol. 2023. PMID: 36803812 Review.
In addition, over time the nonphysiological stimulation of striatal dopamine receptors by l-dopa containing drugs leads to the genesis of l-dopa-induced dyskinesias that can become very disabling in many cases. ...
In addition, over time the nonphysiological stimulation of striatal dopamine receptors by l-dopa containing drugs leads to the genesi …
Plasma concentrations of L-dopa and 3-methoxydopa and improvement in clinical ratings and motor performance in patients with Parkinsonism treated with L-dopa alone or in combination with amantadine.
Pilling JB, Baker J, Iversen LL, Iversen SD, Robbins T. Pilling JB, et al. J Neurol Neurosurg Psychiatry. 1975 Feb;38(2):129-35. doi: 10.1136/jnnp.38.2.129. J Neurol Neurosurg Psychiatry. 1975. PMID: 1097598 Free PMC article. Clinical Trial.
Amantadine withdrawal also failed to cause any significant change in plasma concentrations of L-dopa or its metabolite 3-methoxy-dopa in these patients. In a group of 27 patients seen regularly as outpatients measurements of plasma L-dopa failed to correlate …
Amantadine withdrawal also failed to cause any significant change in plasma concentrations of L-dopa or its metabolite 3-methoxy-d …
Is L-dopa an endogenous neurotransmitter?
Misu Y, Goshima Y. Misu Y, et al. Trends Pharmacol Sci. 1993 Apr;14(4):119-23. doi: 10.1016/0165-6147(93)90082-u. Trends Pharmacol Sci. 1993. PMID: 8100096 Review.
Since the 1960s, L-3,4-dihydroxyphenylalanine (L-dopa), a precursor of dopamine, has been thought to occur in the cytoplasm of catecholaminergic neurones. ...This hypothesis is mainly based on the findings that L-dopa is released in a transmitter-like manner …
Since the 1960s, L-3,4-dihydroxyphenylalanine (L-dopa), a precursor of dopamine, has been thought to occur in the cytoplasm of …
Sinemet and the treatment of Parkinsonism.
Boshes B. Boshes B. Ann Intern Med. 1981 Mar;94(3):364-70. doi: 10.7326/0003-4819-94-3-364. Ann Intern Med. 1981. PMID: 7013595 Review.
Sinemet (a combination of levodopa with carbidopa, a dopa-decarboxylase inhibitor) has replaced levodopa for early treatment of parkinsonism. ...Levodopa with or without dopa decarboxylase is not a cure for parkinsonism. ...
Sinemet (a combination of levodopa with carbidopa, a dopa-decarboxylase inhibitor) has replaced levodopa for early trea …
3-O-Methyldopa inhibits astrocyte-mediated dopaminergic neuroprotective effects of L-DOPA.
Asanuma M, Miyazaki I. Asanuma M, et al. BMC Neurosci. 2016 Jul 25;17(1):52. doi: 10.1186/s12868-016-0289-0. BMC Neurosci. 2016. PMID: 27456338 Free PMC article.
BACKGROUND: We evaluated the effects of 3-O-methyldopa (3-OMD), a metabolite of L-DOPA which is formed by catechol-O-methyltransferase (COMT), on the uptake, metabolism, and neuroprotective effects of L-DOPA in striatal astrocytes. ...The uptake of L-DOPA int …
BACKGROUND: We evaluated the effects of 3-O-methyldopa (3-OMD), a metabolite of L-DOPA which is formed by catechol-O-methyltransferas …
L-DOPA-induced hyperhomocysteinemia in Parkinson's disease: Elephant in the room.
Paul R, Borah A. Paul R, et al. Biochim Biophys Acta. 2016 Sep;1860(9):1989-97. doi: 10.1016/j.bbagen.2016.06.018. Epub 2016 Jun 16. Biochim Biophys Acta. 2016. PMID: 27318154 Review.
BACKGROUND: Dopamine replacement therapy by its precursor, L-3.4-dihydroxyphenylalanine (L-DOPA), has been the treatment of choice for Parkinson's disease. However, the possible contributory effect of L-DOPA therapy on the progression of Parkinson's disease m …
BACKGROUND: Dopamine replacement therapy by its precursor, L-3.4-dihydroxyphenylalanine (L-DOPA), has been the treatment of ch …
Current Advances in L-DOPA and DOPA-Peptidomimetics: Chemistry, Applications and Biological Activity.
Bizzarri BM, Tortolini S, Rotelli L, Botta G, Saladino R. Bizzarri BM, et al. Curr Med Chem. 2015;22(36):4138-65. doi: 10.2174/0929867322666150625095748. Curr Med Chem. 2015. PMID: 26112144 Review.
L-3,4-Dihydroxyphenylalanine [2-amino-3-(3,4-dihydroxyphenyl) propanoic acid (L-DOPA) is a natural constituent of animal and plant tissue derived from post-translational modification of the amino acid tyrosine. ...Among them, L-DOPA-containing peptides (L- …
L-3,4-Dihydroxyphenylalanine [2-amino-3-(3,4-dihydroxyphenyl) propanoic acid (L-DOPA) is a natural constituent of animal and p …
45,144 results
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